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Cited by 311Redox biology and oxidative stressAntioxidant Activity and Oxidative StressSulfur Compounds in Biology

Methionine oxidation and reduction in proteins

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Kim, Geumsoo, Weiss, Stephen J., Levine, Rodney L.·2014·Biochimica et Biophysica Acta (BBA) - General Subjects
DOI 10.1016/j.bbagen.2013.04.038PMC PMC3766491
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Abstract

Background Cysteine and methionine are the two sulfur containing amino acids in proteins. While the roles of protein-bound cysteinyl residues as endogenous antioxidants are well appreciated, those of methionine remain largely unexplored. Scope We summarize the key roles of methionine residues in proteins. Major conclusion Recent studies establish that cysteine and methionine have remarkably similar functions. General significance Both cysteine and methionine serve as important cellular antioxidants, stabilize the structure of proteins, and can act as regulatory switches through reversible oxidation and reduction. This article is part of a Special Issue entitled Current methods to study reactive oxygen species - pros and cons and biophysics of membrane proteins. Guest Editor: Christine Winterbourn.

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Cited by

Sorted by citations

Authors
Kim, G., Weiss, S. J., & Levine, R. L.
Affiliations
  • National Heart, Lung, and Blood Institute (US)
  • University of Michigan (US)
Corresponding author
Levine, Rodney L.
ORCID
Venue
Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher
Elsevier BV
Published
2014-02
Volume
1840
Issue
2
Pages
901-905
ISSN
0304-4165 (ISSN-L)
DOI
10.1016/j.bbagen.2013.04.038
PMC
PMC3766491
OpenAlex
W2044036144
Cited by
311
References
2
Citations by year
2026: 20 · 2025: 28 · 2024: 34 · 2023: 25 · 2022: 24 · 2021: 37 · 2020: 30 · 2019: 30 · 2018: 30 · 2017: 16 · 2016: 13 · 2015: 15 · 2014: 7 · 2013: 1
FWCI
1.13
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (ZIAHL000225)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020572)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Keywords
methionine oxidation, protein oxidation, cysteine, sulfur-containing amino acids, redox regulation, reactive oxygen species
MeSH terms
Animals, Humans, Methionine, Oxidation-Reduction, Proteins

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