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Advances in mass spectrometry driven O-glycoproteomics
Abstract
Background Global analyses of proteins and their modifications by mass spectrometry are essential tools in cell biology and biomedical research. Analyses of glycoproteins represent particular challenges and we are only at the beginnings of the glycoproteomic era. Some of the challenges have been overcome with N-glycoproteins and proteome-wide analysis of N-glycosylation sites is accomplishable today but only by sacrificing information of structures at individual glycosites. More recently advances in analysis of O-glycoproteins have been made and proteome-wide analysis of O-glycosylation sites is becoming available as well. Scope of review Here we discuss the challenges of analysis of O-glycans and new O-glycoproteomics strategies focusing on O-GalNAc and O-Man glycoproteomes. Major conclusions A variety of strategies are now available for proteome-wide analysis of O-glycosylation sites enabling functional studies. However, further developments are still needed for complete analysis of glycan structures at individual sites for both N- and O-glycoproteomics strategies. General significance The advances in O-glycoproteomics have led to identification of new biological functions of O-glycosylation and a new understanding of the importance of where O-glycans are positioned on proteins.
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“It is clear that the glycome of an organism is far, far more complex than that of its genome, transcriptome or proteome, and it is only recently that ' glycomics ' has become practically feasible (1065, 1081 -1089).”
From Biological roles of glycans (2017) · cites this paper as [1089]
In the citing paper
“It is clear that the glycome of an organism is far, far more complex than that of its genome, transcriptome or proteome, and it is only recently that ' glycomics ' has become practically feasible (1065, 1081 -1089).”
From Biological roles of glycans (2017) · cites this paper as [1089]
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Metadata
- Authors
- Levery, S. B., Steentoft, C., Halim, A., Narimatsu, Y., Clausen, H., & Vakhrushev, S. Y.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Vakhrushev, Sergey Y.
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 1850
- Issue
- 1
- Pages
- 33-42
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W2004160810
- Cited by
- 111
- References
- 93
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 14 · 2020: 11 · 2019: 9 · 2018: 11 · 2017: 18 · 2016: 16 · 2015: 12
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- The Danish National Research Foundation (DNRF107)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- O-glycosylation sites, O-glycans, glycan structure analysis, N-glycoproteomics
- MeSH terms
- Cell Line, Glycoproteins, Glycosylation, Humans, Polysaccharides, Mass Spectrometry, Proteome, Proteomics, Cell Line, Tumor
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