Formation and functions of the corneocyte lipid envelope (CLE)

Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate

Brash, A. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23679 · Cited by 1,335 · see citing works

Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorèze 2009

Oji, V., Tadini, G., Akiyama, M., Blanchet‐Bardon, C., Bodemer, C., Bourrat, E., Coudiere, P., DiGiovanna, J. J., Elias, P. M., Fischer, J., et al. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.11.020 · Cited by 781 · see citing works

Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transfer

Akiyama, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24834 · Cited by 392 · see citing works

Mutations in ABCA12 Underlie the Severe Congenital Skin Disease Harlequin Ichthyosis

Kelsell, D. P., Norgett, E. E., Unsworth, H., Teh, M., Cullup, T., Mein, C. A., Dopping-Hepenstal, J. P., Dale, A. B., Tadini, G., Fleckman, P. H., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/429844 · Cited by 351 · see citing works

Lipid and protein structures in the permeability barrier of mammalian epidermis.

Downing, D. T. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41520-2 · Cited by 315 · see citing works

Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1

Jobard, F. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.1.107 · Cited by 278 · see citing works

Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2orCGI-58/ABHD5

Schweiger, M., Lass, A., Zimmermann, R., Eichmann, T. O., & Zechner, R. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00099.2009 · Cited by 272 · see citing works

CGI-58 Interacts with Perilipin and Is Localized to Lipid Droplets

Yamaguchi, T., Omatsu, N., Matsushita, S., & Osumi, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403920200 · Cited by 258 · see citing works

Loss of functional ELOVL4 depletes very long-chain fatty acids (≥C28) and the unique ω-O-acylceramides in skin leading to neonatal death

Vasireddy, V., Uchida, Y., Salem, N., Kim, S. Y., Mandal, M. N. A., Reddy, G. B., Bodepudi, R., Alderson, N. L., Brown, J. C., Hama, H., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl480 · Cited by 247 · see citing works

Deficiency of Epidermal Protein-Bound ω-Hydroxyceramides in Atopic Dermatitis

Macheleidt, O., Sandhoff, K., & Kaiser, H. W. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01833.x · Cited by 232 · see citing works

Ceramides Are Bound to Structural Proteins of the Human Foreskin Epidermal Cornified Cell Envelope

Marekov, L. N., & Steinert, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17763 · Cited by 217 · see citing works

12R-lipoxygenase deficiency disrupts epidermal barrier function

Epp, N., Fürstenberger, G., Müller, K., de Juanes, S., Leitges, M., Haußer, I., Thieme, F., Liebisch, G., Schmitz, G., & Krieg, P. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612116 · Cited by 194 · see citing works

Covalently bound ω-hydroxyacylsphingosine in the stratum corneum

Wertz, P. W., & Downing, D. T. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90290-6 · Cited by 189 · see citing works

Lamellar Body-Enriched Fractions from Neonatal Mice: Preparative Techniques and Partial Characterization

Grayson, S., Johnson-Winegar, A. G., Wintroub, B. U., Isseroff, R. R., Epstein, E. H., & Elias, P. M. (1985) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12276826 · Cited by 187 · see citing works

Thematic review series: Skin Lipids. Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism

Elias, P. M., Williams, M. L. K., Holleran, W. M., Jiang, Y. J., & Schmuth, M. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800002-jlr200 · Cited by 186 · see citing works

Omega-Hydroxyceramides are Required for Corneocyte Lipid Envelope (CLE) Formation and Normal Epidermal Permeability Barrier Function

Behne, M. J., Uchida, Y., Seki, T., de Montellano, P. R. O., Elias, P. M., & Holleran, W. M. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00846.x · Cited by 163 · see citing works

Lipoxygenases Mediate the Effect of Essential Fatty Acid in Skin Barrier Formation

Zheng, Y., Yin, H., Boeglin, W. E., Elias, P. M., Crumrine, D. A., Beier, D. R., & BRASH, A. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.251496 · Cited by 156 · see citing works

The Role of the Corneocyte Lipid Envelopes in Cohesion of the Stratum Corneum

Wertz, P. W., Swartzendruber, D. C., Kitko, D. J., Madison, K. C., & Downing, D. T. (1989) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12277394 · Cited by 141 · see citing works

Relationship between covalently bound ceramides and transepidermal water loss (TEWL)

Meguro, S., Arai, Y., Masukawa, Y., Uie, K., & Tokimitsu, I. (2000) · Archives of Dermatological Research · doi:10.1007/s004030000160 · Cited by 135 · see citing works

Aloxe3 Knockout Mice Reveal a Function of Epidermal Lipoxygenase-3 as Hepoxilin Synthase and Its Pivotal Role in Barrier Formation

Krieg, P., Rosenberger, S. F., de Juanes, S., Latzko, S., Hou, J. L., Dick, A., Kloz, U., van der Hoeven, F., Haußer, I., Esposito, I., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.250 · Cited by 134 · see citing works

Ceramidase Activity in Bacterial Skin Flora as a Possible Cause of Ceramide Deficiency in Atopic Dermatitis

Ohnishi, Y., Okino, N., Ito, M., & Imayama, S. (1999) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.6.1.101-104.1999 · Cited by 116 · see citing works

Accumulation of protein‐bound epidermal glucosylceramides in β‐glucocerebrosidase deficient type 2 Gaucher mice

Doering, T., Proia, R. L., & Sandhoff, K. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00274-4 · Cited by 90 · see citing works

Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs

Melton, J. L., Wertz, P. W., Swartzendruber, D. C., & Downing, D. T. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90018-x · Cited by 77 · see citing works

Origin of the Corneocyte Lipid Envelope (CLE): Observations in Harlequin Ichthyosis and Cultured Human Keratinocytes

Elias, P. M., Fartasch, M., Crumrine, D. A., Behne, M. J., Uchida, Y., & Holleran, W. M. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00124-5.x · Cited by 72 · see citing works

The hepoxilin connection in the epidermis

BRASH, A. R., Yu, Z., Boeglin, W. E., & Schneider, C. G. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05909.x · Cited by 72 · see citing works

Fatty Acid 2-Hydroxylase, Encoded by FA2H, Accounts for Differentiation-associated Increase in 2-OH Ceramides during Keratinocyte Differentiation

Uchida, Y., Hama, H., Alderson, N. L., Douangpanya, S., Wang, Y., Crumrine, D. A., Elias, P. M., & Holleran, W. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611562200 · Cited by 67 · see citing works

Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis

Houben, E., Holleran, W. M., Yaginuma, T., Mao, C., Obeid, L. M., Rogiers, V., Takagi, Y., Elias, P. M., & Uchida, Y. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600001-jlr200 · Cited by 65 · see citing works

Cellular Changes that Accompany Shedding of Human Corneocytes

Lin, T., Crumrine, D. A., Ackerman, L. D., Santiago, J.-L., Roelandt, T., Uchida, Y., Hupe, M., Fabriàs, G., Abad, J. L., Rice, R. H., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.173 · Cited by 60 · see citing works

Neutral Lipid Storage Leads to Acylceramide Deficiency, Likely Contributing to the Pathogenesis of Dorfman–Chanarin Syndrome

Uchida, Y., Cho, Y., Moradian, S., Kim, J., Nakajima, K., Crumrine, D. A., Park, K., Ujihara, M., Akiyama, M., Shimizu, H., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.145 · Cited by 55 · see citing works

Ceramidase activity in porcine epidermis

Wertz, P. W., & Downing, D. T. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80985-r · Cited by 55 · see citing works

Activation of bacterial ceramidase by anionic glycerophospholipids: possible involvement in ceramide hydrolysis on atopic skin by Pseudomonas ceramidase

Kita, K., Sueyoshi, N., Okino, N., Inagaki, M., Ishida, H., Kiso, M., Imayama, S., Nakamura, T., & Ito, M. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3620619 · Cited by 34 · see citing works

Epidermal Ceramidase Activity Regulates Epidermal Desquamation via Stratum Corneum Acidification

Houben, E., Hachem, J. P., Paépe, K. D., & Rogiers, V. (2008) · Skin Pharmacology and Physiology · doi:10.1159/000114872 · Cited by 30 · see citing works

Towards Optimal pH of the Skin and Topical Formulations: From the Current State of the Art to Tailored Products

Lukić, M. Ž., Pantelić, I., & Savic, S. D. (2021) · Cosmetics · doi:10.3390/cosmetics8030069 · Cited by 474 · see citing works

Role of lipids in the formation and maintenance of the cutaneous permeability barrier

Feingold, K. R., & Elias, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.007 · Cited by 383 · see citing works

Permeation enhancers in transdermal drug delivery: benefits and limitations

Kováčik, A., Kopečná, M., & Vávrová, K. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1713087 · Cited by 372 · see citing works

Multifaceted pathways protect human skin from UV radiation

Natarajan, V. T., Ganju, P., Ramkumar, A., Grover, R., & Gokhale, R. S. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1548 · Cited by 244 · see citing works

Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides

Kihara, A. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.04.001 · Cited by 238 · see citing works

Skin lipids in health and disease: A review

Knox, S. E., & O’Boyle, N. M. (2021) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2021.105055 · Cited by 201 · see citing works

Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation

Ohno, Y., Nakamichi, S., Ohkuni, A., Kamiyama, N., Naoe, A., Tsujimura, H., Yokose, U., Sugiura, K., Ishikawa, J., Akiyama, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503491112 · Cited by 168 · see citing works

Fingerpad‐Inspired Multimodal Electronic Skin for Material Discrimination and Texture Recognition

Lee, G., Son, J. H., Lee, S., Kim, S. W., Kim, D., Nguyen, N. N., Lee, S. G., & Cho, K. (2021) · Advanced Science · doi:10.1002/advs.202002606 · Cited by 153 · see citing works

Ceramides in Skin Health and Disease: An Update

Uchida, Y., & Park, K. (2021) · American Journal of Clinical Dermatology · doi:10.1007/s40257-021-00619-2 · Cited by 138 · see citing works

Filaggrin and beyond

Stefanovic, N., & Irvine, A. D. (2023) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2023.09.009 · Cited by 142 · see citing works

PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis

Hirabayashi, T., tatsuki, A., Kaneko, A., Senoo, Y., Shibata, A., Takama, H., Yokoyama, K., Nishito, Y., Ono, T., Taya, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms14609 · Cited by 135 · see citing works

Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS

Kawana, M., Miyamoto, M., Ohno, Y., & Kihara, A. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120000671 · Cited by 129 · see citing works

Modelling the Complexity of Human Skin In Vitro

Hofmann, E., Schwarz, A., Fink, J., Kamolz, L.-P., & Kotzbeck, P. (2023) · Biomedicines · doi:10.3390/biomedicines11030794 · Cited by 129 · see citing works

Corneocyte lipid envelope (CLE), the key structure for skin barrier function and ichthyosis pathogenesis

Akiyama, M. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.06.002 · Cited by 113 · see citing works

The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia

Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi, R., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141904 · Cited by 90 · see citing works

Glucocerebrosidase: Functions in and Beyond the Lysosome

Boer, D. E. C., van Smeden, J., Bouwstra, J. A., & Aerts, J. M. F. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030736 · Cited by 101 · see citing works

Lipid functions in skin: Differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model

Kendall, A. C., Kiezel‐Tsugunova, M., Brownbridge, L. C., Harwood, J. L., & Nicolaou, A. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.03.016 · Cited by 101 · see citing works

Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases

Suzuki, M., Ohno, Y., & Kihara, A. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100235 · Cited by 101 · see citing works

Lipids and the Permeability and Antimicrobial Barriers of the Skin

Wertz, P. W. (2018) · Journal of Lipids · doi:10.1155/2018/5954034 · Cited by 98 · see citing works

PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides

Grond, S., Eichmann, T. O., Dubrac, S., Kolb, D., Schmuth, M., Fischer, J., Crumrine, D. A., Elias, P. M., Haemmerle, G., Zechner, R., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.08.036 · Cited by 95 · see citing works

Stratum corneum lipid and cytokine biomarkers at age 2 months predict the future onset of atopic dermatitis

Berdyshev, E. V., Kim, J., Kim, B. E., Goleva, E., Lyubchenko, T. A., Bronova, I. A., Bronoff, A. S., Xiao, O., Kim, J., Kim, S., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.02.013 · Cited by 91 · see citing works

SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation

Takeichi, T., Hirabayashi, T., Miyasaka, Y., Kawamoto, A., Okuno, Y., Taguchi, S., Tanahashi, K., Murase, C., Takama, H., Tanaka, K., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci130675 · Cited by 89 · see citing works

The Pathogenic and Therapeutic Implications of Ceramide Abnormalities in Atopic Dermatitis

Fujii, M. (2021) · Cells · doi:10.3390/cells10092386 · Cited by 84 · see citing works

Corneocytes: Relationship between Structural and Biomechanical Properties

Évora, A. S., Adams, M. J., Johnson, S. A., & Zhang, Z. (2021) · Skin Pharmacology and Physiology · doi:10.1159/000513054 · Cited by 83 · see citing works

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Fluhr, J. W., Moore, D. J., Lane, M. E., Lachmann, N., & Rawlings, A. V. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19745 · Cited by 78 · see citing works

Lipids: Source of Static Electricity of Regenerative Natural Substances and Nondestructive Energy Harvesting

Kim, D. W., Kim, S., & Jeong, U. (2018) · Advanced Materials · doi:10.1002/adma.201804949 · Cited by 64 · see citing works

Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid ω- O -acylceramide

Yamamoto, H., Hattori, M., Chamulitrat, W., Ohno, Y., & Kihara, A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917525117 · Cited by 63 · see citing works

The physical chemistry of the stratum corneum lipids

Boncheva, M. (2014) · International Journal of Cosmetic Science · doi:10.1111/ics.12162 · Cited by 62 · see citing works

Direct evidence of acid-base interactions in gecko adhesion

Singla, S., Jain, D., Zoltowski, C. M., Voleti, S., Stark, A. Y., Niewiarowski, P. H., & Dhinojwala, A. (2021) · Science Advances · doi:10.1126/sciadv.abd9410 · Cited by 60 · see citing works

Ceramides in the skin barrier

Vávrová, K., Kováčik, A., & Opálka, L. (2017) · European Pharmaceutical Journal · doi:10.1515/afpuc-2017-0004 · Cited by 61 · see citing works

State of the art in Stratum Corneum research: The biophysical properties of ceramides

Schmitt, T., & Neubert, R. H. H. (2018) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2018.09.017 · Cited by 58 · see citing works

New Insights into the Role of PPARγ in Skin Physiopathology

Briganti, S., Mosca, S., Nardo, A. D., Flori, E., & Ottaviani, M. (2024) · Biomolecules · doi:10.3390/biom14060728 · Cited by 59 · see citing works

PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier

Pichery, M., Huchenq, A., Sandhoff, R., Severino‐Freire, M., Zaafouri, S., Opálka, L., Levade, T., Soldan, V., Bertrand‐Michel, J., Lhuillier, É., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx079 · Cited by 56 · see citing works

The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function

Hirabayashi, T., Murakami, M., & Kihara, A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.09.010 · Cited by 54 · see citing works

ABHD5 stimulates PNPLA1-mediated ω-O-acylceramide biosynthesis essential for a functional skin permeability barrier

Kien, B., Grond, S., Haemmerle, G., Lass, A., Eichmann, T. O., & Radner, F. P. W. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m089771 · Cited by 53 · see citing works

Resistance to Water Diffusion in the Stratum Corneum Is Depth-Dependent

van Logtestijn, M. D. A., Domínguez‐Hüttinger, E., Stamatas, G. N., & Tanaka, R. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117292 · Cited by 49 · see citing works

Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope

Crumrine, D. A., Khnykin, D., Krieg, P., Man, M., Celli, A., Mauro, T. M., Wakefield, J. S., Menon, G. K., Mauldin, E. A., Miner, J. H., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.11.005 · Cited by 48 · see citing works

Use of contraceptive depot medroxyprogesterone acetate is associated with impaired cervicovaginal mucosal integrity

Zalenskaya, I. A., Chandra, N., Yousefieh, N., Fang, X., Adedipe, O. E., Jackson, S. S., Anderson, S. M., Mauck, C. K., Schwartz, J. L., Thurman, A. R., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120583 · Cited by 46 · see citing works

Phospholipids in Cosmetic Carriers

van Hoogevest, P., & Fahr, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-16573-4_6 · Cited by 47 · see citing works

Electroactive Electrospun Nanofibrous Scaffolds: Innovative Approaches for Improved Skin Wound Healing

Zhang, Y., Zheng, Z., Zhu, S., Xu, L., Zhang, Q., Gao, J., Ye, M., Shen, S., Xing, J., Wu, M., et al. (2025) · Advanced Science · doi:10.1002/advs.202416267 · Cited by 47 · see citing works

Phytosphingosine enhances moisture level in human skin barrier through stimulation of the filaggrin biosynthesis and degradation leading to NMF formation

Choi, H. K., Cho, Y. H., Lee, E. O., Kim, J. W., & Park, C. S. (2017) · Archives of Dermatological Research · doi:10.1007/s00403-017-1782-8 · Cited by 46 · see citing works

Skin Lipid Barrier: Structure, Function and Metabolism

Berdyshev, E. V. (2024) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2024.16.5.445 · Cited by 44 · see citing works

Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes

Karim, N., Phinney, B. S., Salemi, M., Wu, P., Naeem, M., & Rice, R. H. (2019) · Experimental Dermatology · doi:10.1111/exd.13925 · Cited by 44 · see citing works

Therapeutic targeting of the IL-13 pathway in skin inflammation

Tubau, C., & Puig, L. (2020) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2020.1858802 · Cited by 43 · see citing works

State of the Art in Stratum Corneum Research. Part II: Hypothetical Stratum Corneum Lipid Matrix Models

Schmitt, T., & Neubert, R. H. H. (2020) · Skin Pharmacology and Physiology · doi:10.1159/000509019 · Cited by 43 · see citing works

Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice

Kim, S.-N., Akindehin, S., Kwon, H.-J., Son, Y.-H., Saha, A., Jung, Y.-S., Seong, J. K., Lim, K., Sung, J.-H., Maddipati, K. R., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-27221-7 · Cited by 42 · see citing works

Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics

Murakami, M., Yamamoto, K., & Taketomi, Y. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0089-2 · Cited by 41 · see citing works

Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders

Moskot, M., Bocheńska, K., Jakóbkiewicz‐Banecka, J., Banecki, B., & Gabig‐Cimińska, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010247 · Cited by 39 · see citing works

Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production

Miyamoto, M., Itoh, N., Sawai, M., Sassa, T., & Kihara, A. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.07.689 · Cited by 40 · see citing works

Mechanisms of penetration and diffusion of drugs and cosmetic actives across the human Stratum corneum

Neubert, R. H. H. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114394 · Cited by 38 · see citing works

The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi

Revol-Cavalier, J., Quaranta, A., Newman, J. W. I., BRASH, A. R., Hámberg, M., & Wheelock, C. E. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00520 · Cited by 45 · see citing works

The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function

Chiba, T., Thomas, C. P., Calcutt, M. W., Boeglin, W. E., O’Donnell, V. B., & BRASH, A. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.711267 · Cited by 37 · see citing works

Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency

Gruber, R. W., Sugarman, J. L., Crumrine, D. A., Hupe, M., Mauro, T. M., Mauldin, E. A., Thyssen, J. P., Brandner, J. M., Hennies, H.-C., Schmuth, M., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.12.012 · Cited by 36 · see citing works

Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes

Merleev, A. A., Le, S. T., Alexanian, C. C., Toussi, A. M., Xie, Y., Marusina, A. I., Watkins, S. M., Patel, F., Billi, A. C., Wiedemann, J., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.159762 · Cited by 36 · see citing works

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis

Zhang, L., Ferreyros, M., Feng, W., Hupe, M., Crumrine, D. A., Chen, J., Elias, P. M., Holleran, W. M., Niswander, L. A., Hohl, D., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161465 · Cited by 35 · see citing works

The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications

Schild, J., Kalvodová, A., Zbytovská, J., Farwick, M., & Pyko, C. (2024) · International Journal of Cosmetic Science · doi:10.1111/ics.12972 · Cited by 34 · see citing works

Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation

Grond, S., Radner, F. P. W., Eichmann, T. O., Kolb, D., Grabner, G. F., Wolinski, H., Gruber, R. W., Hofer, P., Heier, C., Schauer, S., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.09.025 · Cited by 34 · see citing works

Permeability Barrier and Microstructure of Skin Lipid Membrane Models of Impaired Glucosylceramide Processing

Sochorová, M., Staňková, K., Pullmannová, P., Kováčik, A., Zbytovská, J., & Vávrová, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-06990-7 · Cited by 32 · see citing works

Formulation‐based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives

Sallam, M. A., Prakash, S., Kumbhojkar, N., Shields, C. W., & Mitragotri, S. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10215 · Cited by 32 · see citing works

The Potential Role of Impaired Notch Signalling in Atopic Dermatitis

Melnik, B. C. (2015) · Acta Dermato Venereologica · doi:10.2340/00015555-1898 · Cited by 32 · see citing works

Expression and Function of Group IIE Phospholipase A2 in Mouse Skin

Yamamoto, K., Miki, Y., Sato, H., Nishito, Y., Gelb, M. H., Taketomi, Y., & Murakami, M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.734657 · Cited by 32 · see citing works

Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice

Honda, Y., Kitamura, T., Naganuma, T., Takaya, A., Ohno, Y., Sassa, T., & Kihara, A. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.11.008 · Cited by 31 · see citing works

An overview of epidermal lamellar bodies: Novel roles in biological adaptations and secondary barriers

Menon, G. K., Lee, S. E., & Lee, S.-H. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.03.005 · Cited by 31 · see citing works

Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols

Lin, M., Hsu, F., Crumrine, D. A., Meyer, J. M., Elias, P. M., & Miner, J. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-49684-y · Cited by 32 · see citing works

Late cornified envelope (LCE) proteins: distinct expression patterns of LCE2 and LCE3 members suggest nonredundant roles in human epidermis and other epithelia

Niehues, H., van Vlijmen‐Willems, I. M. J. J., Bergboer, J. G. M., Kersten, F. F. J., Narita, M., Hendriks, W. J. A. J., van den Bogaard, E. H. J., Zeeuwen, P. L. J. M., & Schalkwijk, J. (2015) · British Journal of Dermatology · doi:10.1111/bjd.14284 · Cited by 31 · see citing works

Barrier function‐related genes and proteins have an altered expression in acne‐involved skin

Dull, K., Lénárt, K., Dajnoki, Z., Póliska, S., Uchiyama, E., Hendrik, Z., Szegedi, A., & Törőcsik, D. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19062 · Cited by 31 · see citing works

Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation

Konieczny, P., Lichawska-Cieślar, A., Kwiecińska, P., Cichy, J., Pietrzycka, R., Szukała, W., Declercq, W., Devos, M., Paziewska, A., Rumieńczyk, I., et al. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01853-2 · Cited by 29 · see citing works

ABHD5—A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions

Schratter, M., Lass, A., & Radner, F. P. W. (2022) · Metabolites · doi:10.3390/metabo12111015 · Cited by 29 · see citing works

Acylceramide is a key player in skin barrier function: insight into the molecular mechanisms of skin barrier formation and ichthyosis pathogenesis

Akiyama, M. (2020) · FEBS Journal · doi:10.1111/febs.15497 · Cited by 28 · see citing works

The Chemistry and Biology of 6‐Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family

Kováčik, A., Roh, J., & Vávrová, K. (2014) · ChemBioChem · doi:10.1002/cbic.201402153 · Cited by 28 · see citing works

Long and very long lamellar phases in model stratum corneum lipid membranes

Pullmannová, P., Ermakova, E. V., Kováčik, A., Opálka, L., Maixner, J., Zbytovská, J., Kučerka, N., & Vávrová, K. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m090977 · Cited by 27 · see citing works

Measurement of trihydroxy-linoleic acids in stratum corneum by tape-stripping: Possible biomarker of barrier function in atopic dermatitis

Chiba, T., Nakahara, T., Kohda, F., Ichiki, T., Manabe, M., & Furue, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210013 · Cited by 27 · see citing works

Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)–Deficient Canines

Mauldin, E. A., Crumrine, D. A., Casal, M. L., Jeong, S., Opálka, L., Vávrová, K., Uchida, Y., Park, K., Craiglow, B. G., Choate, K. A., et al. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.02.008 · Cited by 26 · see citing works

Determining the structure of protein-bound ceramides, essential lipids for skin barrier function

Ohno, Y., Nakamura, T., Iwasaki, T., Katsuyama, A., Ichikawa, S., & Kihara, A. (2023) · iScience · doi:10.1016/j.isci.2023.108248 · Cited by 25 · see citing works

Addressing Differentiation in Live Human Keratinocytes by Assessment of Membrane Packing Order

Gutowska‐Owsiak, D., Podobas, E. I., Eggeling, C., Ogg, G. S., & de la Serna, J. B. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.573230 · Cited by 23 · see citing works

Monitoring dermal penetration and permeation kinetics of topical products; the role of Raman microspectroscopy

Bielfeldt, S., Bonnier, F., Byrne, H. J., Chourpa, I., Dancik, Y., Lane, M. E., Lunter, D. J., Munnier, E., Puppels, G. J., Tfayli, A. M., et al. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116709 · Cited by 26 · see citing works

The genetics of the skin barrier in eczema and other allergic disorders

Marenholz, I., Esparza-Gordillo, J., & Lee, Y. (2015) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000194 · Cited by 23 · see citing works

Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier

Lemaire, G., Olivero, M., Rouquet, V., Moga, A., Pagnon-Minot, A., Cenizo, V., & Portes, P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0268384 · Cited by 22 · see citing works

Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons

Simoniello, P., Wiedemann, J., Zink, J., Thönnes, E., Stange, M., Layer, P. G., Kovács, M., Podda, M., Durante, M., & Fournier, C. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2015.00294 · Cited by 21 · see citing works

Preclinical study models of psoriasis: State-of-the-art techniques for testing pharmaceutical products in animal and nonanimal models

Yadav, K., Singh, D., Singh, M. R., Minz, S., Gnanakani, S. P. E., Sucheta, Yadav, R., Vora, L. K., Sahu, K. K., Bagchi, A., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109945 · Cited by 20 · see citing works

Unique skin abnormality in patients with peanut allergy but no atopic dermatitis

Berdyshev, E. V., Goleva, E., Bronova, I. A., Bronoff, A. S., Hoffman, B. C., Ramirez-Gama, M. A., Garcia, S. L., Crumrine, D. A., Elias, P. M., Cho, C. B., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.06.015 · Cited by 19 · see citing works

Biophysical aspects of the skin barrier: towards increased non-invasive extraction and optimized biomarker sampling

Morin, M. (2021) · doi:10.24834/isbn.9789178772254 · Cited by 19 · see citing works

Hair follicles modulate skin barrier function

Ford, N. C., Benedeck, R. E., Mattoon, M. T., Peterson, J. K., Mesler, A. L., Veniaminova, N. A., Gardon, D. J., Tsai, S.-Y., Uchida, Y., & Wong, S. Y. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114347 · Cited by 22 · see citing works

Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations

Yamamoto, M., Sassa, T., Kyono, Y., Uemura, H., Kugo, M., Hayashi, H., Imai, Y., Yamanishi, K., & Kihara, A. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.15725 · Cited by 18 · see citing works

Activation of SIRT1 Enhances Epidermal Permeability Barrier Formation through Ceramide Synthase 2– and 3–Dependent Mechanisms

Shin, K., Lim, C. J., Park, H. Y., Kim, S., Kim, B., Lee, Y., Chung, H.-J., Jeong, S., Park, K., & Park, K. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.12.021 · Cited by 17 · see citing works

Correlations between Skin Condition Parameters and Ceramide Profiles in the Stratum Corneum of Healthy Individuals

Akiyama, F., Takahashi, N., Ueda, Y., Tada, S., Takeuchi, N., Ohno, Y., & Kihara, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158291 · Cited by 18 · see citing works

Selectivity in cornified envelop binding of ceramides in human skin and the role of LXR inactivation on ceramide binding

Boiten, W. A., Helder, R. W. J., van Smeden, J., & Bouwstra, J. A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.05.003 · Cited by 16 · see citing works

Dietary ceramide 2-aminoethylphosphonate, a marine sphingophosphonolipid, improves skin barrier function in hairless mice

Tomonaga, N., Manabe, Y., Aida, K., & Sugawara, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-70888-0 · Cited by 16 · see citing works

Ichthyosis and hereditary cornification disorders in dogs

Mauldin, E. A., & Elias, P. M. (2021) · Veterinary Dermatology · doi:10.1111/vde.13033 · Cited by 16 · see citing works

In vivo Raman Confocal Spectroscopy in the Investigation of the Skin Barrier

Darlenski, R., & Fluhr, J. W. (2016) · Current problems in dermatology · doi:10.1159/000441587 · Cited by 15 · see citing works

A synthetic C16 omega-hydroxyphytoceramide improves skin barrier functions from diversely perturbed epidermal conditions

Oh, M. J., Nam, J. J., Lee, E. O., Kim, J. W., & Park, C. S. (2016) · Archives of Dermatological Research · doi:10.1007/s00403-016-1674-3 · Cited by 15 · see citing works

Role of Omega-Hydroxy Ceramides in Epidermis: Biosynthesis, Barrier Integrity and Analyzing Method

Ge, F., Sun, K., Hu, Z., & Dong, X. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24055035 · Cited by 14 · see citing works

The effect of two endogenous retinoids on the mRNA expression profile in human primary keratinocytes, focusing on genes causing autosomal recessive congenital ichthyosis

Törmä, H., Bergström, A., Ghiasifarahani, G., & Berne, B. (2014) · Archives of Dermatological Research · doi:10.1007/s00403-014-1476-4 · Cited by 14 · see citing works

Spatial distribution of active compounds in stratum corneum—partitioning between corneocytes and lipid matrix

Sjövall, P., Grégoire, S., Wargniez, W., Skedung, L., Detroyer, A., & Luengo, G. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-66418-x · Cited by 13 · see citing works

Elucidation of the Synthetic Mechanism of Acylceramide, an Essential Lipid for Skin Barrier Function

Ohno, Y. (2017) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.17-00126 · Cited by 13 · see citing works

The Roles of sPLA2s in Skin Homeostasis and Disease

Yamamoto, K., Hakoi, H., Nomura, S., & Murakami, M. (2023) · Biomolecules · doi:10.3390/biom13040668 · Cited by 12 · see citing works

Early-life protein-bound skin ceramides help predict the development of atopic dermatitis

Chang, C., Berdyshev, E. V., Milanzi, E., Lodge, C., Lopez, D. J., Bronova, I. A., Koplin, J. J., Peters, R. L., Tang, M. L. K., Dharmage, S. C., et al. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.10.041 · Cited by 12 · see citing works

Lipidomic Profiling of the Epidermis in a Mouse Model of Dermatitis Reveals Sexual Dimorphism and Changes in Lipid Composition before the Onset of Clinical Disease

Franco, J., Rajwa, B. P., Ferreira, C. R., Sundberg, J. P., & HogenEsch, H. (2020) · Metabolites · doi:10.3390/metabo10070299 · Cited by 12 · see citing works

Knockdown of SDR9C7 Impairs Epidermal Barrier Function

Youssefian, L., Niaziorimi, F., Saeidian, A. H., South, A. P., Khosravi-Bachehmir, F., Khodavaisy, S., Vahidnezhad, H., & Uitto, J. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.030 · Cited by 11 · see citing works

Mechanisms of Sensitive Skin and the Soothing Effects of Active Compounds: A Review

Chen, B., Tang, H., Liu, Z., Qiao, K., Chen, X., Liu, S., Pan, N., Chen, T., & Liu, Z. (2024) · Cosmetics · doi:10.3390/cosmetics11060190 · Cited by 14 · see citing works

439 Mutations in the epidermal fatty acid and ceramide metabolic pathway reveal functions of the Corneocyte-Bound Lipid Envelope (CLE)

Elias, P. M., Man, M., & Crumrine, D. A. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.02.458 · Cited by 1 · see citing works

Lipid Metabolic Events Underlying the Formation of the Corneocyte Lipid Envelope

Wertz, P. W. (2021) · Skin Pharmacology and Physiology · doi:10.1159/000513261 · Cited by 29 · see citing works

Study of Corneocyte Lipid Envelope

Hrdinová, I. (2022) · Digital Repository (National Repository of Grey Literature)

655 Origin and functions of the corneocyte lipid envelope

Crumrine, D. A., Khnykin, D., Krieg, P., Man, M., Celli, A., Mauro, T. M., Menon, G. K., Mauldin, E. A., Miner, J. H., BRASH, A. R., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.03.664 · Cited by 2 · see citing works

The importance of stratum corneum ω‐linoleoyloxyacylceramides in human skin barrier health: their biochemistry, processing enzymes and metabolites involved in corneocyte lipid envelope maturation

Rawlings, A. V., Lane, M. E., & Voegeli, R. (2024) · International Journal of Cosmetic Science · doi:10.1111/ics.12955 · Cited by 10 · see citing works