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Formation and functions of the corneocyte lipid envelope (CLE)
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Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review here the structure, composition, and possible functions of this structure, with insights provided by inherited and acquired disorders of lipid metabolism. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
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“A portion of EO ceramides are converted into protein-bound hydroxy (P-O) ceramides (Fig. 1B), which are connected to cross-linked proteins constituting the cornified envelope, a structure located beneath the surface of corneocytes (20)(21)(22).”
From Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS (2020) · cites this paper as [21]
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Metadata
- Authors
- Elias, P. M., Gruber, R., Crumrine, D., Menon, G., Williams, M. L., Wakefield, J. S., Holleran, W. M., & Uchida, Y.
- Affiliations
- San Francisco VA Medical Center (US)
- California Academy of Sciences (US)
- University of California, San Francisco (US)
- Corresponding author
- Elias, Peter M.
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 1841
- Issue
- 3
- Pages
- 314-318
- ISSN
- 1388-1981 (ISSN-L)
- PMC
- PMC3943821
- OpenAlex
- W2060531073
- Cited by
- 169
- References
- 32
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 23 · 2023: 17 · 2022: 6 · 2021: 16 · 2020: 16 · 2019: 12 · 2018: 14 · 2017: 13 · 2016: 10 · 2015: 10 · 2014: 9
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR019098, R01AR019098, R01AR061106)
- Topics
- Health Sciences › Medicine › Dermatology › Genetic and rare skin diseases.
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Surface Properties and Treatments
- Keywords
- stratum corneum, ceramide, corneocytes, skin barrier, lipid metabolism disorders, skin barrier function, epidermal lipids
- MeSH terms
- Epidermal Cells, Animals, Epidermis, Humans, Lipids, Lipid Metabolism
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