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Cited by 383Advancements in Transdermal Drug DeliverySkin and Cellular Biology ResearchPlant Surface Properties and Treatments

The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.

Role of lipids in the formation and maintenance of the cutaneous permeability barrier

Feingold, Kenneth R., Elias, Peter M.·2014·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2013.11.007
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Abstract

The major function of the skin is to form a barrier between the internal milieu and the hostile external environment. A permeability barrier that prevents the loss of water and electrolytes is essential for life on land. The permeability barrier is mediated primarily by lipid enriched lamellar membranes that are localized to the extracellular spaces of the stratum corneum. These lipid enriched membranes have a unique structure and contain approximately 50% ceramides, 25% cholesterol, and 15% free fatty acids with very little phospholipid. Lamellar bodies, which are formed during the differentiation of keratinocytes, play a key role in delivering the lipids from the stratum granulosum cells into the extracellular spaces of the stratum corneum. Lamellar bodies contain predominantly glucosylceramides, phospholipids, and cholesterol and following the exocytosis of lamellar lipids into the extracellular space of the stratum corneum these precursor lipids are converted by beta glucocerebrosidase and phospholipases into the ceramides and fatty acids, which comprise the lamellar membranes. The lipids required for lamellar body formation are derived from de novo synthesis by keratinocytes and from extra-cutaneous sources. The lipid synthetic pathways and the regulation of these pathways are described in this review. In addition, the pathways for the uptake of extra-cutaneous lipids into keratinocytes are discussed. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.

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Crossref · 10.1016/j.bbalip.2013.11.007

Cites

215 of 215 references verified0 citation errors · 0 not checkable

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  1. Tawada, 2013, J. Invest. Dermatol.

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Metadata

Authors
Feingold, K. R., & Elias, P. M.
Affiliations
San Francisco VA Medical Center (US)
Corresponding author
Feingold, Kenneth R.
ORCID
Elias, Peter M.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2014-03
Volume
1841
Issue
3
Pages
280-294
ISSN
1388-1981 (ISSN-L)
DOI
10.1016/j.bbalip.2013.11.007
OpenAlex
W2123766496
Cited by
383
References
215
Citations by year
2026: 19 · 2025: 23 · 2024: 26 · 2023: 31 · 2022: 32 · 2021: 37 · 2020: 42 · 2019: 35 · 2018: 30 · 2017: 29 · 2016: 41 · 2015: 26 · 2014: 12
FWCI
3.32
Type
journal article
Language
en
Open access
closed
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Surface Properties and Treatments
Keywords
skin permeability barrier, stratum corneum, lamellar membranes, ceramide, cholesterol, free fatty acids, lamellar bodies, keratinocyte differentiation, glucosylceramide, beta-glucocerebrosidase, phospholipase, lipogenesis, epidermal lipids
MeSH terms
Epidermal Cells, Animals, Cell Differentiation, Epidermis, Humans, Lipids, Water-Electrolyte Balance, Keratinocytes, Lipid Metabolism

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