Role of lipids in the formation and maintenance of the cutaneous permeability barrier

PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

Zhang, F. L., & Casey, P. J. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.001325 · Cited by 2,018

Molecular physiology of reverse cholesterol transport.

Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448

Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

Yen, C.-L. E., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800018-jlr200 · Cited by 1,105

Enzymes of triacylglycerol synthesis and their regulation

Coleman, R. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00051-1 · Cited by 985

Lipopenia and Skin Barrier Abnormalities in DGAT2-deficient Mice

Stone, S. J., Myers, H. M., Watkins, S. M., Brown, B. E., Feingold, K. R., Elias, P. M., & Farese, R. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311000200 · Cited by 612

Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores.

Zechner, R., Kienesberger, P. C., Haemmerle, G., Zimmermann, R., & Lass, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800031-jlr200 · Cited by 576

The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model.

Ghadially, R., Brown, B. E., Sequeira‐Martin, S. M., Kr, F., & Elias, P. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117919 · Cited by 561

The important role of stratum corneum lipids for the cutaneous barrier function

van Smeden, J., Janssens, M., Gooris, G. S., & Bouwstra, J. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.006 · Cited by 549

pH Directly Regulates Epidermal Permeability Barrier Homeostasis, and Stratum Corneum Integrity/Cohesion

Hachem, J. P., Crumrine, D. A., Fluhr, J. W., Brown, B. E., Feingold, K. R., & Elias, P. M. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12365.x · Cited by 526

Cell death by cornification

Eckhart, L., Lippens, S., Tschachler, E., & Declercq, W. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.010 · Cited by 515

Mutations in CGI-58, the Gene Encoding a New Protein of the Esterase/Lipase/Thioesterase Subfamily, in Chanarin-Dorfman Syndrome

Lefèvre, C., Jobard, F., Caux, F. A., Bouadjar, B., Karaduman, A., Heilig, R., Lakhdar, H., Wollenberg, A., Verret, J.-L., Weissenbach, J., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/324121 · Cited by 465

Thematic review series: Skin Lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis

Feingold, K. R. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700013-jlr200 · Cited by 461

Ionic Calcium Reservoirs in Mammalian Epidermis: Ultrastructural Localization by Ion-Capture Cytochemistry

Menon, G. K., Grayson, S., & Elias, P. M. (1985) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12273485 · Cited by 457

Transepidermal water loss: the signal for recovery of barrier structure and function.

Grubauer, G., Elias, P. M., & Feingold, K. R. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38361-9 · Cited by 412

Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transfer

Akiyama, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24834 · Cited by 392

Psychological Stress Perturbs Epidermal Permeability Barrier Homeostasis

Garg, A., Chren, M., Sands, L. P., Matsui, M. S., MARENUS, K. D., Feingold, K. R., & Elias, P. M. (2001) · Archives of Dermatology · doi:10.1001/archderm.137.1.53 · Cited by 382

PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS

Schafer, W. R., & Rine, J. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.001233 · Cited by 377

Generation of Free Fatty Acids from Phospholipids Regulates Stratum Corneum Acidification and Integrity

Fluhr, J. W., Kao, J. S., Ahn, S. K., Feingold, K. R., Elias, P. M., & Jain, M. K. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01399.x · Cited by 362

Short-Term Glucocorticoid Treatment Compromises Both Permeability Barrier Homeostasis and Stratum Corneum Integrity: Inhibition of Epidermal Lipid Synthesis Accounts for Functional Abnormalities

Kao, J. S., Fluhr, J. W., Man, M., Fowler, A. J., Hachem, J. P., Crumrine, D. A., Ahn, S. K., Brown, B. E., Elias, P. M., & Feingold, K. R. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12053.x · Cited by 362

Stress-Induced Changes in Skin Barrier Function in Healthy Women

Altemus, M. M., Rao, B. K., Dhabhar, F. S., Ding, W., & Granstein, R. D. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01373.x · Cited by 347

Glycerol and the skin: holistic approach to its origin and functions

Fluhr, J. W., Darlenski, R., & Surber, C. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08643.x · Cited by 339

Effects of petrolatum on stratum corneum structure and function

Ghadially, R., Halkier-Sorensen, L., & Elias, P. M. (1992) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(92)70060-s · Cited by 332

Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment

Scott, I. R., & Harding, C. R. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90230-7 · Cited by 326

Sustained Serine Proteases Activity by Prolonged Increase in pH Leads to Degradation of Lipid Processing Enzymes and Profound Alterations of Barrier Function and Stratum Corneum Integrity

Hachem, J. P., Man, M.-Q., Crumrine, D. A., Uchida, Y., Brown, B. E., Rogiers, V., Roseeuw, D. I., Feingold, K. R., & Elias, P. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23838.x · Cited by 314

Thematic Review Series: Skin Lipids. Antimicrobial lipids at the skin surface

Drake, D. R., Brogden, K. A., Dawson, D. V., & Wertz, P. W. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r700016-jlr200 · Cited by 305

Optimization of Physiological Lipid Mixtures for Barrier Repair

Man, M., Feingold, K. R., Thornfeldt, C. R., & Elias, P. M. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12340135 · Cited by 294

Glycerol-3-phosphate acyltransferases: Rate limiting enzymes of triacylglycerol biosynthesis

Wendel, A. A., Lewin, T. M., & Coleman, R. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.10.010 · Cited by 292

Recent progress on acyl CoA: lysophospholipid acyltransferase research

Shindou, H., Hishikawa, D., 原山, 武., Yuki, K., & Shimizu, T. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800035-jlr200 · Cited by 286

Lamellar Body Secretory Response to Barrier Disruption

Menon, G. K., Feingold, K. R., & Elias, P. M. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12497866 · Cited by 285

Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease.

Holleran, W. M., Ginns, E. I., Menon, G. K., Grundmann, J., Fartasch, M., McKinney, C. E., Elias, P. M., & Sidransky, E. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117160 · Cited by 285

Loss of ceramide synthase 3 causes lethal skin barrier disruption

Jennemann, R., Rabionet, M., Gorgas, K., Epstein, S., Dalpke, A. H., Rothermel, U., Bayerle, A., van der Hoeven, F., Imgrund, S., Kirsch, J., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr494 · Cited by 283

Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1

Jobard, F. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.1.107 · Cited by 278

Barrier recovery is impeded at neutral pH, independent of ionic effects: implications for extracellular lipid processing

Mauro, T. M., Grayson, S., Gao, W., Man, M., Kriehuber, E., Behne, M. J., Feingold, K. R., & Elias, P. M. (1998) · Archives of Dermatological Research · doi:10.1007/s004030050293 · Cited by 270

Low Humidity Stimulates Epidermal DNA Synthesis and Amplifies the Hyperproliferative Response to Barrier Disruption: Implication for Seasonal Exacerbations of Inflammatory Dermatoses

Denda, M., Sato, J., Tsuchiya, T., Elias, P. M., & Feingold, K. R. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00364.x · Cited by 262

Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function.

Holleran, W. M., Takagi, Y., Menon, G. K., Legler, G., Kr, F., & Elias, P. M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116374 · Cited by 261

Ceramide synthesis in the epidermis

Rabionet, M., Gorgas, K., & Sandhoff, R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.08.011 · Cited by 256

Molecular Cloning and Expression of a Novel Keratinocyte Protein (Psoriasis-associated fatty acid-binding protein [PA-FABP]) that Is Highly Up-Regulated in Psoriatic Skin and that Shares Similarity to Fatty Acid-Binding Proteins

Madsen, P., Rasmussen, H. H., Leffers, H. C. B., Honoré, B., & Celis, J. E. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12616641 · Cited by 256

Loss of functional ELOVL4 depletes very long-chain fatty acids (≥C28) and the unique ω-O-acylceramides in skin leading to neonatal death

Vasireddy, V., Uchida, Y., Salem, N., Kim, S. Y., Mandal, M. N. A., Reddy, G. B., Bodepudi, R., Alderson, N. L., Brown, J. C., Hama, H., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl480 · Cited by 247

Relationship of epidermal lipogenesis to cutaneous barrier function.

Grubauer, G., Feingold, K. R., & Elias, P. M. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38670-3 · Cited by 242

Barrier function regulates epidermal lipid and DNA synthesis

Proksch, E., Holleran, W. M., Menon, G. K., Elias, P. M., & Feingold, K. R. (1993) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1993.tb00222.x · Cited by 235

Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice

Aberg, K. M., Radek, K. A., Choi, E., Kim, D.-K., Demerjian, M., Hupe, M., Kerbleski, J. F., Gallo, R. L., Ganz, T., Mauro, T. M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31726 · Cited by 234

Exposure to a Dry Environment Enhances Epidermal Permeability Barrier Function

Denda, M., Sato, J., Masuda, Y. M., Tsuchiya, T., Koyama, J., Kuramoto, M., Elias, P. M., & Feingold, K. R. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00333.x · Cited by 233

Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice

Fluhr, J. W., Man, M., Brown, B. E., Wertz, P. W., Crumrine, D. A., Sundberg, J. P., Feingold, K. R., & Elias, P. M. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12134.x · Cited by 231

Exogenous Lipids Influence Permeability Barrier Recovery in Acetone-Treated Murine Skin

Man, M. (1993) · Archives of Dermatology · doi:10.1001/archderm.1993.01680270066008 · Cited by 227

Co-Regulation and Interdependence of the Mammalian Epidermal Permeability and Antimicrobial Barriers

Aberg, K. M., Man, M., Gallo, R. L., Ganz, T., Crumrine, D. A., Brown, B. E., Choi, E., Kim, D.-K., Schröder, J. M., Feingold, K. R., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701099 · Cited by 226

Regulation of epidermal sphingolipid synthesis by permeability barrier function.

Holleran, W., Kr, F., Man, M., Gao, W., Lee, J., & Pm, E. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41978-9 · Cited by 225

Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids

Fujita, N. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.6.711 · Cited by 222

Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation.

Holleran, W. M., Man, M., Gao, W., Menon, G. K., Elias, P. M., & Feingold, K. R. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115439 · Cited by 220

Widespread Expression of Serum Amyloid A in Histologically Normal Human Tissues: Predominant Localization to the Epithelium

Urieli-Shoval, S., Cohen, P., Eisenberg, S., & Matzner, Y. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804601206 · Cited by 219

Mechanisms by Which Psychologic Stress Alters Cutaneous Permeability Barrier Homeostasis and Stratum Corneum Integrity

Choi, E., Brown, B. E., Crumrine, D. A., Chang, S., Man, M., Elias, P. M., & Feingold, K. R. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23589.x · Cited by 212

The mammalian cutaneous permeability barrier: defective barrier function is essential fatty acid deficiency correlates with abnormal intercellular lipid deposition.

Pm, E., & Brown, B. E. (1978) · PubMed · Cited by 211

Serine Protease Signaling of Epidermal Permeability Barrier Homeostasis

Hachem, J. P., Houben, E., Crumrine, D. A., Man, M.-Q., Schürer, N., Roelandt, T., Choi, E. H., Uchida, Y., Brown, B. E., Feingold, K. R., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700351 · Cited by 210

De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements.

Menon, G. K., Feingold, K. R., Moser, A. H., Brown, B. E., & Elias, P. M. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34355-8 · Cited by 208

Calcium and potassium are important regulators of barrier homeostasis in murine epidermis.

Lee, S. H., Elias, P. M., Proksch, E., Menon, G. K., Mao-Qiang, M. A. N., & Feingold, K. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115617 · Cited by 208

Thematic Review Series: Skin Lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology

Schmuth, M., Jiang, Y. J., Dubrac, S., Elias, P. M., & Feingold, K. R. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800001-jlr200 · Cited by 204

Dermatology in General Medicine

Smoller, B. R. (2003) · Journal of Cutaneous Pathology · doi:10.1034/j.1600-0560.2003.00115.x · Cited by 204

Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-linked ichthyosis.

Elias, P. M., Williams, M. L. K., Maloney, M. E., Bonifas, J. A., Brown, B. E., Grayson, S., & Epstein, E. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111552 · Cited by 195

Stratum corneum lipids in disorders of cornification: increased cholesterol sulfate content of stratum corneum in recessive x-linked ichthyosis.

Williams, M. L. K., & Elias, P. M. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110391 · Cited by 195

Cholesterol synthesis is required for cutaneous barrier function in mice.

Feingold, K. R., Man, M., Menon, G. K., Cho, S. S., Brown, B. E., & Elias, P. M. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114899 · Cited by 194

12R-lipoxygenase deficiency disrupts epidermal barrier function

Epp, N., Fürstenberger, G., Müller, K., de Juanes, S., Leitges, M., Haußer, I., Thieme, F., Liebisch, G., Schmitz, G., & Krieg, P. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612116 · Cited by 194

Ultrastructural Localization of Calcium in Psoriatic and Normal Human Epidermis

Menon, G. K. (1991) · Archives of Dermatology · doi:10.1001/archderm.1991.01680010067010 · Cited by 189

Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and α-linolenate

Hansen, H. S., & Jensen, B. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90009-8 · Cited by 189

Growth Retardation, Impaired Triacylglycerol Catabolism, Hepatic Steatosis, and Lethal Skin Barrier Defect in Mice Lacking Comparative Gene Identification-58 (CGI-58)

Radner, F. P. W., Streith, I. E., Schoiswohl, G., Schweiger, M., Kumari, M., Eichmann, T. O., Rechberger, G. N., Köfeler, H. C., Eder, S., Schauer, S., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081877 · Cited by 188

Thematic review series: Skin Lipids. Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism

Elias, P. M., Williams, M. L. K., Holleran, W. M., Jiang, Y. J., & Schmuth, M. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800002-jlr200 · Cited by 186

Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy

Herrmann, T. R. W., van der Hoeven, F., Gröne, H., Stewart, A. F., Langbein, L., Kaiser, I., Liebisch, G., Gosch, I., Buchkremer, F., Drobnik, W., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207080 · Cited by 186

Localization of calcium in murine epidermis following disruption and repair of the permeability barrier

Menon, G. K., Elias, P. M., Lee, S. H., & Feingold, K. R. (1992) · Cell and Tissue Research · doi:10.1007/bf00645052 · Cited by 185

The role of sphingolipid metabolism in cutaneous permeabilitybarrier formation

Breiden, B., & Sandhoff, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.08.010 · Cited by 181

Water loss from the skin of term and preterm babies.

Rutter, N., & Hull, D. (1979) · Archives of Disease in Childhood · doi:10.1136/adc.54.11.858 · Cited by 179

UVB-Induced Alterations in Permeability Barrier Function: Roles for Epidermal Hyperproliferation and Thymocyte-Mediated Response

Haratake, A., Uchida, Y., Schmuth, M., Tanno, O., Yasuda, R., Epstein, J. H., Elias, P. M., & Holleran, W. M. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12292163 · Cited by 172

Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier

Jensen, J., Schütze, S., Förl, M., Krönke, M., & Proksch, E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5307 · Cited by 170

The Regulation and Role of Epidermal Lipid Synthesis

Feingold, K. R. (1991) · Advances in lipid research · doi:10.1016/b978-0-12-024924-4.50007-9 · Cited by 169

Formation and functions of the corneocyte lipid envelope (CLE)

Elias, P. M., Gruber, R., Crumrine, D., Menon, G., Williams, M. L., Wakefield, J. S., Holleran, W. M., & Uchida, Y. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.09.011 · Cited by 169

Fatty acids are required for epidermal permeability barrier function.

Mao-Qiang, M., Elias, P. M., & Kr, F. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116652 · Cited by 167

Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1 , the Gene Responsible for Very-Long-Chain Fatty Acid Production

Sassa, T., Ohno, Y., Suzuki, S., Nomura, T., Nishioka, C., Kashiwagi, T., Hirayama, T., Akiyama, M., Taguchi, R., Shimizu, H., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-13 · Cited by 167

Stress alters cutaneous permeability barrier homeostasis

Denda, M., Tsuchiya, T., Elias, P. M., & Feingold, K. R. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.2.r367 · Cited by 166

Large-scale identification of human genes implicated in epidermal barrier function

Toulza, È., Mattiuzzo, N. R., Galliano, M., Jonca, N., Dossat, C., Jacob, D. J., de Daruvar, A., Wincker, P., Serre, G., & Guerrin, M. (2007) · Genome biology · doi:10.1186/gb-2007-8-6-r107 · Cited by 165

Impaired Epidermal Ceramide Synthesis Causes Autosomal Recessive Congenital Ichthyosis and Reveals the Importance of Ceramide Acyl Chain Length

Eckl, K., Tidhar, R., Thiele, H., Oji, V., Haußer, I., Brodesser, S., Preil, M., Önal-Akan, A., Stock, F., Müller, D., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.153 · Cited by 162

Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice

Li, W., Sandhoff, R., Kono, M., Zerfas, P. M., Hoffmann, V., Ding, B. C.-H., Proia, R. L., & Deng, C. (2007) · International Journal of Biological Sciences · doi:10.7150/ijbs.3.120 · Cited by 162

Epidermal Lamellar Granules Transport Different Cargoes as Distinct Aggregates

Ishida‐Yamamoto, A., Simon, M., Kishibe, M., Miyauchi, Y., Takahashi, H., Yoshida, S., O’Brien, T. J., Serre, G., & Iizuka, H. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22515.x · Cited by 158

Mutations in CERS3 Cause Autosomal Recessive Congenital Ichthyosis in Humans

Radner, F. P. W., Marrakchi, S., Kirchmeier, P., Kim, G.-J., Ribiérre, F., Kamoun, B., Abid, L., Leipoldt, M., Turki, H., Schempp, W., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003536 · Cited by 151

Selective Obliteration of the Epidermal Calcium Gradient Leads to Enhanced Lamellar Body Secretion

Menon, G. K., Price, L. F., Bommannan, B., et al. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12377921 · Cited by 149

Effect of essential fatty acid deficiency on the epidermal sphingolipids of the rat

Wertz, P. W., Cho, E. S., & Downing, D. T. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90058-9 · Cited by 148

Permeability Barrier Disorder in Niemann–Pick Disease: Sphingomyelin–Ceramide Processing Required for Normal Barrier Homeostasis

Schmuth, M., Man, M., Weber, F., Gao, W., Feingold, K. R., Fritsch, P. O., Elias, P. M., & Holleran, W. M. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00081.x · Cited by 147

Topical stratum corneum lipids accelerate barrier repair after tape stripping, solvent treatment and some but not all types of detergent treatment

Yang, L., MAO-QlANG, M., Taljebini, M., Elias, P. M., & Kr, F. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1995.tb02738.x · Cited by 144

Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin

Zettersten, E., Ghadially, R., Feingold, K. R., Crumrine, D. A., & Elias, P. M. (1997) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(97)70140-3 · Cited by 144

Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival

Cameron, D. J., Tong, Z., Yang, Z., Kaminoh, J., Kamiyah, S., Chen, H., Zeng, J., Chen, Y., Luo, L., & Zhang, K. (2007) · International Journal of Biological Sciences · doi:10.7150/ijbs.3.111 · Cited by 142

Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development

Miyazaki, M., Dobrzyń, A., Elias, P. M., & Ntambi, J. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503132102 · Cited by 141

Interferon-γ Decreases Ceramides with Long-Chain Fatty Acids: Possible Involvement in Atopic Dermatitis and Psoriasis

Tawada, C., Kanoh, H., Nakamura, M., Mizutani, Y., Fujisawa, T., Banno, Y., & Seishima, M. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.364 · Cited by 140

Thematic Review Series: Glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity

Gimeno, R. E., & Cao, J. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800013-jlr200 · Cited by 137

Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands

Chen, H. C., Smith, S. J., Tow, B., Elias, P. M., & Farese, R. V. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13880 · Cited by 135

Stratum Corneum Acidification in Neonatal Skin: Secretory Phospholipase A2 and the Sodium/Hydrogen Antiporter-1 Acidify Neonatal Rat Stratum Corneum

Fluhr, J. W., Behne, M. J., Brown, B. E., Moskowitz, D. G., Selden, C., Man, M., Mauro, T. M., Elias, P. M., & Feingold, K. R. (2004) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2003.00204.x · Cited by 133

The role of lipoxygenases in epidermis

Krieg, P., & Fürstenberger, G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.08.005 · Cited by 133

Fatty aldehyde and fatty alcohol metabolism: Review and importance for epidermal structure and function

Rizzo, W. B. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.09.001 · Cited by 132

Acute Acidification of Stratum Corneum Membrane Domains Using Polyhydroxyl Acids Improves Lipid Processing and Inhibits Degradation of Corneodesmosomes

Hachem, J. P., Roelandt, T., Schürer, N., Xu, P., Fluhr, J. W., Giddelo, C., Man, M., Crumrine, D. A., Roseeuw, D. I., Feingold, K. R., et al. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.249 · Cited by 131

Increased skin permeability in preterm infants

Nachman, R. L., & Esterly, N. B. (1971) · The Journal of Pediatrics · doi:10.1016/s0022-3476(71)80311-6 · Cited by 130

Acute Modulations in Permeability Barrier Function Regulate Epidermal Cornification

Demerjian, M., Hachem, J. P., Tschachler, E., Denecker, G., Declercq, W., Vandenabeele, P., Mauro, T. M., Hupe, M., Crumrine, D. A., Roelandt, T., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070161 · Cited by 129

Systemic distribution of apolipoprotein E secreted by grafts of epidermal keratinocytes: implications for epidermal function and gene therapy.

Fenjves, E. S., Gordon, D. A., Pershing, L. K., et al. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8803 · Cited by 128

Metabolism of essential fatty acids by human epidermal enzyme preparations: evidence of chain elongation.

Chapkin, R. S., Ziboh, V. A., Marcelo, C. L., & Voorhees, J. J. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38771-x · Cited by 127

Structural and biochemical basis for the UVB‐induced alterations in epidermal barrier function

Holleran, W. M., Uchida, Y., Halkier-Sørensen, L., Haratake, A., Hara, M., Epstein, J. H., & Elias, P. M. (1997) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1997.tb00214.x · Cited by 126

Lipin proteins and metabolic homeostasis

Reue, K., & Dwyer, J. R. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800052-jlr200 · Cited by 124

The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier

Muñoz‐Garcia, A., Thomas, C. P., Keeney, D. S., Zheng, Y., & BRASH, A. R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.08.020 · Cited by 123

Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands

Chen, H. C., Smith, S. J., Tow, B., Elias, P. M., & Farese, R. V. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213880 · Cited by 123

Role of cholesterol sulfate in epidermal structure and function: Lessons from X-linked ichthyosis

Elias, P. M., Williams, M. L. K., Choi, E. H., & Feingold, K. R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.009 · Cited by 122

Extracellular processing of phospholipids is required for permeability barrier homeostasis.

Mao-Qiang, M., Feingold, K. R., Jain, M. K., & Elias, P. M. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41111-3 · Cited by 119

Secretory Phospholipase A2 Activity Is Required for Permeability Barrier Homeostasis

Man, M., Jain, M. K., Feingold, K. R., & Elias, P. M. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12327246 · Cited by 119

Integrity and Barrier Function of the Epidermis Critically Depend on Glucosylceramide Synthesis

Jennemann, R., Sandhoff, R., Langbein, L., Kaden, S., Rothermel, U., Gallala, H. D., Sandhoff, K., Wiegandt, H., & Gröne, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610304200 · Cited by 117

The Lovastatin-Treated Rodent: A New Model of Barrier Disruption and Epidermal Hyperplasia

Feingold, K. R., Man, M., Proksch, E., Menon, G. K., Brown, B. E., & Elias, P. M. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12461153 · Cited by 116

Decreased Epidermal Lipid Synthesis Accounts for Altered Barrier Function in Aged Mice

Ghadially, R., Brown, B. E., Hanley, K., Reed, J. T., Feingold, K. R., & Elias, P. M. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12338692 · Cited by 114

The epidermal hyperplasia associated with repeated barrier disruption by acetone treatment or tape stripping cannot be attributed to increased water loss

Denda, M., Wood, L. C., Emami, S., et al. (1996) · Archives of Dermatological Research · doi:10.1007/bf02530090 · Cited by 114

Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in murine epidermis. Modulation of enzyme content and activation state by barrier requirements.

Proksch, E., Elias, P. M., & Feingold, K. R. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114514 · Cited by 114

Permeability Barrier Disruption Coordinately Regulates mRNA Levels for Key Enzymes of Cholesterol, Fatty Acid, and Ceramide Synthesis in the Epidermis

Harris, I. R., Farrell, A. M., Grünfeld, C., Holleran, W. M., Elias, P. M., & Feingold, K. R. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12340962 · Cited by 112

The epidermal hyperplasia associated with repeated barrier disruption by acetone treatment or tape stripping cannot be attributed to increased water loss

Denda, M., Wood, L. C., Emami, S., et al. (1996) · Archives of Dermatological Research · doi:10.1007/s004030050051 · Cited by 111

Dietary glucosylceramide improves skin barrier function in hairless mice

Tsuji, K., Mitsutake, S., Ishikawa, J., et al. (2006) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2006.08.005 · Cited by 110

Integrity of the permeability barrier is crucial for maintenance of the epidermal calcium gradient

Menon, G. K., Elias, P. M., & Feingold, K. R. (1994) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1994.tb02892.x · Cited by 110

Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro

Siegenthaler, G., Hotz, R., Chatellard-Gruaz, D., Didierjean, L., Hellman, U., & Saurat, J. ‐. (1994) · Biochemical Journal · doi:10.1042/bj3020363 · Cited by 110

Is Endogenous Glycerol a Determinant of Stratum Corneum Hydration in Humans?

Choi, E. H., Man, M., Wang, F., Zhang, X., Brown, B. E., Feingold, K. R., & Elias, P. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23799.x · Cited by 109

Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4.

McMahon, A., Butovich, I. A., Mata, N. L., Klein, M., Ritter, R., Richardson, J. A., Birch, D. G., Edwards, A. O., & Kędzierski, W. (2007) · PubMed Central · Cited by 107

Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function

Choi, E., Demerjian, M., Crumrine, D. A., Brown, B. E., Mauro, T. M., Elias, P. M., & Feingold, K. R. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00010.2006 · Cited by 104

Ceramide signaling in mammalian epidermis

Uchida, Y. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.09.003 · Cited by 103

Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development

Moulson, C. L., Martin, D. R., Lugus, J. J., Schaffer, J. E., Lind, A. C., & Miner, J. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0431186100 · Cited by 103

Local expression of apolipoprotein A-I gene and a possible role for HDL in primary defence in the carp skin

Concha, M. I., Molina, S., Oyarzun, C. E., et al. (2003) · Fish & Shellfish Immunology · doi:10.1006/fsim.2002.0435 · Cited by 103

Lipid composition of the superficial stratum corneum cells of pig epidermis

GRAY, G. M., White, R. J., WILLIAMS, R. H., & YARDLEYMRC, H. J. (1982) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1982.tb00902.x · Cited by 103

Cellular localization of apolipoprotein D and lecithin:cholesterol acyltransferase mRNA in rhesus monkey tissues by in situ hybridization.

Smith, K., Lawn, R. M., & Wilcox, J. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42739-7 · Cited by 103

Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis

Eckl, K., Krieg, P., Küster, W., Traupe, H., André, F., Wittstruck, N., Fürstenberger, G., & Hennies, H. C. (2005) · Human Mutation · doi:10.1002/humu.20236 · Cited by 103

Functional Consequences of a Neutral pH in Neonatal Rat Stratum Corneum

Fluhr, J. W., Man, M., Brown, B. E., Hachem, J. P., Moskowitz, D. G., Demerjian, M., Haftek, M., Serre, G., Crumrine, D. A., Mauro, T. M., et al. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22726.x · Cited by 102

Neonatal Development of the Stratum Corneum pH Gradient: Localization and Mechanisms Leading to Emergence of Optimal Barrier Function

Behne, M. J., Barry, N. P., Hanson, K. M., Aronchik, I., Clegg, R. W., Gratton, E., Feingold, K. R., Holleran, W. M., Elias, P. M., & Mauro, T. M. (2003) · Journal of Investigative Dermatology · doi:10.1038/jid.2003.11 · Cited by 100

Role of PPAR, LXR, and PXR in epidermal homeostasis and inflammation

Schmuth, M., Moosbrugger-Martinz, V., Blunder, S., & Dubrac, S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.012 · Cited by 100

Permeability barrier requirements regulate epidermal beta-glucocerebrosidase.

Holleran, W. M., Takagi, Y., Menon, G. K., Jackson, S. M., Lee, J. M., Feingold, K. R., & Elias, P. M. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39184-7 · Cited by 99

Characterization and Expression of a Novel Human Fatty Acid-Binding Protein: The Epidermal Type (E-FABP)

Siegenthaler, G., Hotz, R., Chatellard-Gruaz, D., Jaconi, S., & Saurat, J. ‐. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1073 · Cited by 96

The roles of ABCA12 in epidermal lipid barrier formation and keratinocyte differentiation

Akiyama, M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.08.009 · Cited by 94

Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid

Chapkin, R. S., & Ziboh, V. A. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91026-x · Cited by 93

Lamellar Bodies of Human Epidermis

Raymond, A.-A., de Peredo, A. G., Stella, A., Ishida‐Yamamoto, A., Bouyssié, D., Serre, G., Monsarrat, B., & Simon, M. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700334-mcp200 · Cited by 93

trans-4-(Aminomethyl)cyclohexane Carboxylic Acid (T-AMCHA), an Anti-Fibrinolytic Agent, Accelerates Barrier Recovery and Prevents the Epidermal Hyperplasia Induced by Epidermal Injury in Hairless Mice and Humans

Denda, M., Kitamura, K., Elias, P. M., et al. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12276640 · Cited by 92

Barrier Function, Epidermal Differentiation, and Human β-Defensin 2 Expression in Tinea Corporis

Jensen, J., Pfeiffer, S., Akaki, T., Schröder, J., Kleine, M., Neumann, C., Proksch, E., & Brasch, J. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700788 · Cited by 87

Ceramide-Dominant, Barrier-Repair Lipids Improve Childhood Atopic Dermatitis

Chamlin, S. L., Frieden, I. J., Fowler, A. J., et al. (2001) · Archives of Dermatology · doi:10.1001/archderm.137.8.1110 · Cited by 84

The roles of cutaneous lipids in host defense

Fischer, C. L., Blanchette, D. R., Brogden, K. A., Dawson, D. V., Drake, D. R., Hill, J. R., & Wertz, P. W. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.08.012 · Cited by 84

Fatty acid transporters in skin development, function and disease

Lin, M., & Khnykin, D. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.09.016 · Cited by 82

Differential Expression of Fatty Acid Transport Proteins in Epidermis and Skin Appendages

Schmuth, M., Ortegon, A. M., Man, M., et al. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23934.x · Cited by 81

The important role of epidermal triacylglycerol metabolism for maintenance of the skin permeability barrier function

Radner, F. P. W., & Fischer, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.07.013 · Cited by 80

Harlequin ichthyosis unmasked: a defect of lipid transport

Hovnanian, A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25736 · Cited by 79

Lipid abnormalities and lipid-based repair strategies in atopic dermatitis

Elias, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.001 · Cited by 78

Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs

Melton, J. L., Wertz, P. W., Swartzendruber, D. C., & Downing, D. T. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90018-x · Cited by 77

Ontogeny of the Epidermal Permeability Barrier

Williams, M. L., Hanley, K., Elias, P. M., & Feingold, K. R. (1998) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.1998.18 · Cited by 76

A Mutation in LIPN, Encoding Epidermal Lipase N, Causes a Late-Onset Form of Autosomal-Recessive Congenital Ichthyosis

Israeli, S., Khamaysi, Z., Fuchs‐Telem, D., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.02.011 · Cited by 75

Permeability barrier function of skin exposed to ionizing radiation.

Schmuth, M., Sztankay, A., Weinlich, G., et al. (2001) · PubMed · Cited by 74

Structural Basis for the Barrier Abnormality Following Inhibition of HMG CoA Reductase in Murine Epidermis

Menon, G. K., Feingold, K. R., Man, M., Schaude, M., & Elias, P. M. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12555880 · Cited by 73

The hepoxilin connection in the epidermis

BRASH, A. R., Yu, Z., Boeglin, W. E., & Schneider, C. G. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05909.x · Cited by 72

Scavenger Receptor Class B Type I Is Expressed in Cultured Keratinocytes and Epidermis

Tsuruoka, H., Khovidhunkit, W., Brown, B. E., Fluhr, J. W., Elias, P. M., & Feingold, K. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106445200 · Cited by 72

DHCR24 Gene Knockout Mice Demonstrate Lethal Dermopathy with Differentiation and Maturation Defects in the Epidermis

Mirza, R., Hayasaka, S., Takagishi, Y., Kambe, F., Ohmori, S., Maki, K., Yamamoto, M., Murakami, K., Kaji, T., ZADWORNY, D., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700111 · Cited by 71

Analysis on the phenotype of E-FABP-gene knockout mice

Owada, Y., Suzuki, I., Noda, T., et al. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1020524621933 · Cited by 69

Coordinate assembly of lipids and enzyme proteins into epidermal lamellar bodies

Rassner, U. A., Feingold, K. R., Crumrine, D. A., & Elias, P. M. (1999) · Tissue and Cell · doi:10.1054/tice.1999.0050 · Cited by 68

Regulation of ABCG1 expression in human keratinocytes and murine epidermis

Jiang, Y. J., Lü, B., Tarling, E. J., Kim, P., Man, M., Crumrine, D., Edwards, P. A., Elias, P. M., & Feingold, K. R. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m006445 · Cited by 68

Effect of Essential Fatty Acid Deficiency on Cutaneous Sterol Synthesis

Feingold, K. R., Brown, B. E., Lear, S. R., Moser, A. H., & Elias, P. M. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12455835 · Cited by 67

Epidermal HMG CoA Reductase Activity in Essential Fatty Acid Deficiency: Barrier Requirements Rather Than Eicosanoid Generation Regulate Cholesterol Synthesis

Proksch, E., Feingold, K. R., & Elias, P. M. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12650440 · Cited by 66

Abnormal barrier function in the pathogenesis of ichthyosis: Therapeutic implications for lipid metabolic disorders

Elias, P. M., Williams, M. L. K., & Feingold, K. R. (2012) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2011.08.017 · Cited by 64

Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12-LOX and eLOX3

Yu, Z., SCHNEIDER, C., Boeglin, W. E., & BRASH, A. R. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.10.007 · Cited by 61

Altered Water Barrier Function in Epidermal-Type Fatty Acid Binding Protein-Deficient Mice

Owada, Y., Suzuki, I., Suzuki, R., Kondo, H., Takano, H., Yamanaka, H., Kobayashi, H., Sugitani, Y., Tomioka, Y., Terui, T., et al. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01616.x · Cited by 60

Evidence for a novel keratinocyte fatty acid uptake mechanism with preference for linoleic acid: Comparison of oleic and linoleic acid uptake by cultured human keratinocytes, fibroblasts and a human hepatoma cell line

Schürer, N., Stremmel, W., Grundmann, J., Schliep, V., Kleinert, H., Bass, N. M., & Williams, M. L. K. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)90138-4 · Cited by 58

Effect of cutaneous permeability barrier disruption on HMG-CoA reductase, LDL receptor, and apolipoprotein E mRNA levels in the epidermis of hairless mice.

Jackson, S. M., Wood, L. C., Lauer, S., et al. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40544-9 · Cited by 56

Excretion of sterols from the skin of normal and hypercholesterolemic humans

Bhattacharyya, A. K., Connor, W. E., & Spector, A. A. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107012 · Cited by 55

Neutral Lipid Storage Leads to Acylceramide Deficiency, Likely Contributing to the Pathogenesis of Dorfman–Chanarin Syndrome

Uchida, Y., Cho, Y., Moradian, S., Kim, J., Nakajima, K., Crumrine, D. A., Park, K., Ujihara, M., Akiyama, M., Shimizu, H., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.145 · Cited by 55

Calcium‐mediated regulation of the low density lipoprotein receptor and intracellular cholesterol synthesis in human epidermal keratinocytes

Ponec, M., Havekes, L. M., Kempenaar, J. A., et al. (1985) · Journal of Cellular Physiology · doi:10.1002/jcp.1041250113 · Cited by 55

Low Density Lipoprotein Receptor Expression on Keratinocytes in Normal and Psoriatic Epidermis

Mommaas-Kienhuis, A. M., Grayson, S., Wijsman, M. C., et al. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12461024 · Cited by 54

Keratinocyte-specific Expression of Fatty Acid Transport Protein 4 Rescues the Wrinkle-free Phenotype in Slc27a4/Fatp4 Mutant Mice

Moulson, C. L., Lin, M., White, J. M., Newberry, E. P., Davidson, N. O., & Miner, J. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701779200 · Cited by 54

Regulation of ABCA1 expression in human keratinocytes and murine epidermis

Jiang, Y. J., Lü, B., Kim, P., Elias, P. M., & Feingold, K. R. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600163-jlr200 · Cited by 53

Cutaneous Permeability Barrier Disruption Increases Fatty Acid Synthetic Enzyme Activity in the Epidermis of Hairless Mice

OTTEY, K. A., Wood, L. C., Grünfeld, C., Elias, P. M., & Feingold, K. K. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12665893 · Cited by 52

In vivo studies of sterol and squalene secretion by human skin

Nikkari, T., Schreibman, P. H., & AHRENS, E. H. (1974) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36757-2 · Cited by 52

Diversity of mouse lipoxygenases: Identification of a subfamily of epidermal isozymes exhibiting a differentiation‐dependent mRNA expression pattern

Heidt, M., Fürstenberger, G., Vogel, S., et al. (2000) · Lipids · doi:10.1007/s11745-000-0576-0 · Cited by 51

Caveolin Expression and Localization in Human Keratinocytes Suggest a Role in Lamellar Granule Biogenesis

Sando, G. N., Zhu, H., Weis, J., et al. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12051.x · Cited by 51

Iontophoresis Itself on Hairless Mouse Skin Induces the Loss of the Epidermal Calcium Gradient Without Skin Barrier Impairment

Lee, S. H., Jiang, S., Choi, E. H., Feingold, K. R., & Ahn, S. K. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00226.x · Cited by 51

Epidermal Fatty-Acid-Binding Protein in Psoriasis, Basal and Squamous Cell Carcinomas: An Immunohistological Study

Masouyé, I., Saurat, J., & Siegenthaler, G. (2009) · Dermatology · doi:10.1159/000246367 · Cited by 50

Induction of Ceramide Glucosyltransferase Activity in Cultured Human Keratinocytes

Sando, G. N., Howard, E. J., & Madison, K. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.22044 · Cited by 49

Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation

Mizutani, Y., Sun, H., Ohno, Y., Sassa, T., Wakashima, T., Obara, M., Yuyama, K., Kihara, A., & Igarashi, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067317 · Cited by 49

The roles of ABCA12 in keratinocyte differentiation and lipid barrier formation in the epidermis

Akiyama, M. (2011) · Dermato-Endocrinology · doi:10.4161/derm.3.2.15136 · Cited by 48

Impact of stress of marital dissolution on skin barrier recovery: tape stripping and measurement of trans‐epidermal water loss (TEWL)

Muizzuddin, N., Matsui, M. S., MARENUS, K. D., & Maes, D. H. (2003) · Skin Research and Technology · doi:10.1034/j.1600-0846.2003.00354.x · Cited by 47

sPLA2 and the epidermal barrier

Ilić, D., Bollinger, J. M., Gelb, M. H., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.002 · Cited by 46

Synthesis and Secretion of Apolipoprotein E by Cultured Human Keratinocytes

Gordon, D. A., Fenjves, E. S., Williams, D. L., & Taichrnan, L. B. (1989) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep13071302 · Cited by 45

Calcium and potassium inhibit barrier recovery after disruption, independent of the type of insult in hairless mice

Man, M., Mauro, T. M., Bench, G., et al. (1997) · Experimental Dermatology · doi:10.1111/j.1600-0625.1997.tb00143.x · Cited by 43

Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis

Lü, B., Jiang, Y. J., Man, M., Brown, B. E., Elias, P. M., & Feingold, K. R. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500258-jlr200 · Cited by 42

Topical Peroxisome Proliferator Activated Receptor Activators Accelerate Postnatal Stratum Corneum Acidification

Fluhr, J. W., Man, M., Hachem, J. P., Crumrine, D. A., Mauro, T. M., Elias, P. M., & Feingold, K. R. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.218 · Cited by 40

Free sterol metabolism and low density lipoprotein receptor expression as differentiation markers of cultured human keratinocytes

Williams, M. L. K., Mommaas-Kienhuis, A. M., Rutherford, S. L., et al. (1987) · Journal of Cellular Physiology · doi:10.1002/jcp.1041320305 · Cited by 39

Glucosylceramide synthase activity in murine epidermis: quantitation, localization, regulation, and requirement for barrier homeostasis

Chujor, C. S. N., Feingold, K. R., Elias, P. M., et al. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33889-x · Cited by 39

Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation

Fürstenberger, G., Epp, N., Eckl, K., et al. (2006) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2006.05.006 · Cited by 38

The role of abnormalities in the distal pathway of cholesterol synthesis in the Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects (CHILD) syndrome

Seeger, M. A., & Paller, A. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.09.006 · Cited by 37

Localization of epidermal sphingolipid synthesis and serine palmitoyl transferase activity: alterations imposed by permeability barrier requirements

Holleran, W. M., Gao, W., Feingold, K. R., & Elias, P. M. (1995) · Archives of Dermatological Research · doi:10.1007/bf01105075 · Cited by 35

The mechanisms by which lipids coordinately regulate the formation of the protein and lipid domains of the stratum corneum

Feingold, K. R., & Jiang, Y. J. (2011) · Dermato-Endocrinology · doi:10.4161/derm.3.2.14996 · Cited by 35

Localization and regulation of epidermal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by barrier requirements

Proksch, E., Elias, P. M., & Feingold, K. R. (1991) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(91)90126-3 · Cited by 35

The role of sterol-C4-methyl oxidase in epidermal biology

He, M., Smith, L. D., Chang, R. C., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.009 · Cited by 35

Secretion of Apolipoprotein E by Basal Cells in Cultures of Epidermal Keratinocytes

Barra, R. M., Fenjves, E. S., & Taichman, L. B. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12371733 · Cited by 33

Differential Utilization of Linoleic and Arachidonic Acid by Cultured Human Keratinocytes

Schürer, N., Schliep, V., & Williams, M. L. (2009) · Skin Pharmacology · doi:10.1159/000211328 · Cited by 32

Fat in the skin

Radner, F. P. W., Grond, S., Lass, A., & Zechner, R. (2011) · Dermato-Endocrinology · doi:10.4161/derm.3.2.15472 · Cited by 30

The Epidermal Lamellar Body as a Multifunctional Secretory Organelle

Elias, K. R. F. P. M. (2005) · CRC Press eBooks · doi:10.1201/b14173-19 · Cited by 28

The Origin of Plant Sterols in the Skin Surface Lipids in Humans: From Diet to Plasma to Skin

Bhattacharyya, A. K., Connor, W. E., & Lin, D. S. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12534670 · Cited by 27

The role of the abnormalities in the distal pathway of cholesterol biosynthesis in the Conradi–Hünermann–Happle syndrome

Cañueto, J., Girós, M., & González‐Sarmiento, R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.09.002 · Cited by 26

Expression of the Apolipoprotein E Gene in the Skin is Controlled by a Unique Downstream Enhancer

Grehan, S., Allan, C. M., Tse, E., Walker, D., & Taylor, J. M. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.00213.x · Cited by 25

The fatty acid composition of skin and plasma lipids in Refsum's disease

Reynods, D. J., Marks, R., Davies, M. G., et al. (1978) · Clinica Chimica Acta · doi:10.1016/0009-8981(78)90519-3 · Cited by 24

Cloning and chromosomal localisation of the murine epidermal-type fatty acid binding protein gene (Fabpe)

Bleck, B., Hohoff, C., Binas, B., Rüstow, B., Dixkens, C., Hameister, H., Börchers, T., & Spener, F. (1998) · Gene · doi:10.1016/s0378-1119(98)00262-5 · Cited by 24

Topical Liver X Receptor Activators Accelerate Postnatal Acidification of Stratum Corneum and Improve Function in the Neonate

Fluhr, J. W., Crumrine, D. A., Man, M., Moskowitz, D. G., Elias, P. M., & Feingold, K. R. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23964.x · Cited by 23

Expression and Regulation of mRNA for Putative Fatty Acid Transport Related Proteins and Fatty Acyl CoA Synthase in Murine Epidermis and Cultured Human Keratinocytes

Harris, I. R., Farrell, A. M., Memon, R. A., et al. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00383.x · Cited by 23

Synthesis and secretion of apolipoprotein A-I by chick skin.

Tarugi, P., Albertazzi, L., Nicolini, S., et al. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89507-6 · Cited by 22

Bioactive Compounds for Skin Health: A Review

Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345

Lipid abnormalities in atopic skin are driven by type 2 cytokines

Berdyshev, E., Goleva, E., Bronova, I., Dyjack, N., Rios, C., Jung, J., Taylor, P., Jeong, M., Hall, C. F., Richers, B. N., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.98006 · Cited by 283

A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging

Fernandes, A., Rodrigues, P. M., Pintado, M., & Tavaria, F. K. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154824 · Cited by 264

Epithelial barrier repair and prevention of allergy

Goleva, E., Berdyshev, E., & Leung, D. Y. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124608 · Cited by 251

Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis

Elias, P. M., & Wakefield, J. S. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.048 · Cited by 238

Structural and biochemical basis for the UVB‐induced alterations in epidermal barrier function

Holleran, W. M., Uchida, Y., Halkier-Sørensen, L., Haratake, A., Hara, M., Epstein, J. H., & Elias, P. M. (1997) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1997.tb00214.x · Cited by 126

Acute Modulations in Permeability Barrier Function Regulate Epidermal Cornification

Demerjian, M., Hachem, J. P., Tschachler, E., Denecker, G., Declercq, W., Vandenabeele, P., Mauro, T. M., Hupe, M., Crumrine, D. A., Roelandt, T., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070161 · Cited by 129

Structural relationship between epidermal lipid lamellae, lamellar bodies and desmosomes in human epidermis: an ultrastructural study

FARTASCH, M., Bassukas, I. D., & DIEPGKN, T. L. (1993) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1993.tb00138.x · Cited by 122

Aging of the skin barrier

Choi, E. H. (2019) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2019.04.009 · Cited by 145

Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation.

Holleran, W. M., Man, M., Gao, W., Menon, G. K., Elias, P. M., & Feingold, K. R. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115439 · Cited by 220