miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other miRNAs that are highly conserved in metazoans or known to be expressed in myeloid cells, including miR-191-5p, miR-15a-5p, miR-206, miR-335-5p, and miR-339-3p, showed moderate expression levels.
“Other miRNAs that are highly conserved in metazoans or known to be expressed in myeloid cells, including miR-191-5p (ref. 53), miR-15a-5p (ref. 54), miR-206 (ref. 55), miR-335-5p (ref. 56), and miR-339-3p (ref. 56), were included and used as positive controls, and showed moderate expression levels.”
From An integrated expression atlas of miRNAs and their promoters in human and mouse (2017) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Rayner, K. J., Sheedy, F. J., Esau, C. C., Hussain, F. N., Temel, R. E., Parathath, S., van Gils, J. M., Rayner, A. J., Chang, A. N., Suarez, Y., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57275 · Cited by 690 · see citing works
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2
Vasudevan, S., & Steitz, J. A. (2007) · Cell · doi:10.1016/j.cell.2007.01.038 · Cited by 656 · see citing works
Control of Cholesterol Metabolism and Plasma High-Density Lipoprotein Levels by microRNA-144
Ramírez, C. M., Rotllan, N., Vlassov, A. V., Dávalos, A., Li, M., Goedeke, L., Aranda, J. F., Cirera-Salinas, D., Araldi, E., Salerno, A., et al. (2013) · Circulation Research · doi:10.1161/circresaha.112.300626 · Cited by 217 · cited 1× · see citing works
“Recently two independent groups published an LXRα and farnesoid X receptor (FXR) induced expression ofmiR-144 that targeted ABCA1 mRNA and reduced ABCA1mediated cholesterol homeostasis in the liver [24,25].”
BackgroundTruesdell, S. S., Mortensen, R. D., Seo, M., Schroeder, J. C., Lee, J. H., LeTonqueze, O., & Vasudevan, S. (2012) · Scientific Reports · doi:10.1038/srep00842 · Cited by 173 · see citing works
Flagged first, then by citations
Research works printed but not linked: 32
- [1]Ostlund R.E. Jr. A minimal model for human whole body cholesterol metabolism Am. J. Physiol. 265 1993 E513 E520 8214059
- [2]Repa J.J. Mangelsdorf D.J. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis Annu. Rev. Cell Dev. Biol. 16 2000 459 481 11031244
- [3]Lusis A.J. Atherosclerosis Nature 407 2000 233 241 11001066 PMC2826222
- [4]Im S.-S. Osborne T.F. Liver X receptors in atherosclerosis and inflammation Circ. Res. 108 2011 996 1001 21493922 PMC3082200
- [5]Sorrentino V. Nelson J.K. Maspero E. Marques A.R. Scheer L. Polo S. Zelcer N. The LXR–IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation J. Lipid Res. 54 2013 2174 2184 23733886 PMC3708367
- [6]Tontonoz P. Transcriptional and posttranscriptional control of cholesterol homeostasis by liver X receptors Cold Spring Harb. Symp. Quant. Biol. 76 2011 129 137 21859674
- [7]Bories G. Colin S. Vanhoutte J. Derudas B. Copin C. Fanchon M. Daoudi M. Belloy L. Haulon S. Zawadzki C. Jude B. Staels B. Chinetti-Gbaguidi G. Liver X receptor activation stimulates iron export in human alternative macrophages Circ. Res. 113 2013 1196 1205 24036496 PMC3989231
- [8]Schultz J.R. Tu H. Luk A. Repa J.J. Medina J.C. Li L. Schwendner S. Wang S. Thoolen M. Mangelsdorf D.J. Lustig K.D. Shan B. Role of LXRs in control of lipogenesis Genes Dev. 14 2000 2831 2838 11090131 PMC317060
- [9]Zelcer N. Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling J. Clin. Invest. 116 2006 607 614 16511593 PMC1386115
- [10]Calkin A.C. Tontonoz P. Liver X receptor signaling pathways and atherosclerosis Arterioscler. Thromb. Vasc. Biol. 30 2010 1513 1518 20631351 PMC2919217
- [11]Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297 14744438
- [12]Sacco J. Adeli K. MicroRNAs: emerging roles in lipid and lipoprotein metabolism Curr. Opin. Lipidol. 23 2012 220 225 22488426
- [13]Soifer H.S. Rossi J.J. Saetrom P. MicroRNAs in disease and potential therapeutic applications Mol. Ther. 15 2007 2070 2079 17878899
- [14]Weischenfeldt J. Porse B. Bone Marrow-derived Macrophages (BMM): Isolation and Applications, CSH Protocols 2008 ((2008) pdb prot5080) 21356739
- [15]Chandak P.G. Obrowsky S. Radovic B. Doddapattar P. Aflaki E. Kratzer A. Doshi L.S. Povoden S. Ahammer H. Hoefler G. Levak-Frank S. Kratky D. Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice Biochim. Biophys. Acta 1811 2011 1011 1020 21924378 PMC3223411
- [16]Malle E. Hazell L. Stocker R. Sattler W. Esterbauer H. Waeg G. Immunologic detection and measurement of hypochlorite-modified LDL with specific monoclonal antibodies Arterioscler. Thromb. Vasc. Biol. 15 1995 982 989 7541296
- [17]Chennamsetty I. Kostner K.M. Claudel T. Vinod M. Frank S. Weiss T.S. Trauner M. Kostner G.M. Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice J. Lipid Res. 53 2012 2405 2412 22930813 PMC3466008
- [18]Zhong D. Huang G. Zhang Y. Zeng Y. Xu Z. Zhao Y. He X. He F. MicroRNA-1 and microRNA-206 suppress LXRalpha-induced lipogenesis in hepatocytes Cell. Signal. 25 2013 1429 1437 23499676
- [19]Sun D. Zhang J. Xie J. Wei W. Chen M. Zhao X. MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7 FEBS Lett. 586 2012 1472 1479 22673513
- [20]Ramirez C.M. Davalos A. Goedeke L. Salerno A.G. Warrier N. Cirera-Salinas D. Suarez Y. Fernandez-Hernando C. MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1 Arterioscler. Thromb. Vasc. Biol. 31 2011 2707 2714 21885853 PMC3298756
- [22]Rayner K.J. Suarez Y. Davalos A. Parathath S. Fitzgerald M.L. Tamehiro N. Fisher E.A. Moore K.J. Fernandez-Hernando C. MiR-33 contributes to the regulation of cholesterol homeostasis Science 328 2010 1570 1573 (New York, N.Y.) 20466885 PMC3114628
- [23]Horie T. Ono K. Horiguchi M. Nishi H. Nakamura T. Nagao K. Kinoshita M. Kuwabara Y. Marusawa H. Iwanaga Y. Hasegawa K. Yokode M. Kimura T. Kita T. MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo Proc. Natl. Acad. Sci. U. S. A. 107 2010 17321 17326 20855588 PMC2951399
- [25]de Aguiar Vallim T.Q. Tarling E.J. Kim T. Civelek M. Baldan A. Esau C. Edwards P.A. MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor Circ. Res. 112 2013 1602 1612 23519696 PMC3995747
- [26]Ou Z. Wada T. Gramignoli R. Li S. Strom S.C. Huang M. Xie W. MicroRNA hsa-miR-613 targets the human LXRalpha gene and mediates a feedback loop of LXRalpha autoregulation Mol. Endocrinol. 25 2011 584 596 (Baltimore, MD) 21310851 PMC3063084
- [27]Sankaranarayanan S. de la Llera-Moya M. Drazul-Schrader D. Phillips M.C. Kellner-Weibel G. Rothblat G.H. Serum albumin acts as a shuttle to enhance cholesterol efflux from cells J. Lipid Res. 54 2013 671 676 23288948 PMC3617942
- [28]Vasudevan S. Posttranscriptional upregulation by microRNAs Wiley Interdiscip. Rev. RNA 3 2012 311 330 22072587
- [30]Vasudevan S. Tong Y. Steitz J.A. Switching from repression to activation: microRNAs can up-regulate translation Science 318 2007 1931 1934 (New York, N.Y.) 18048652
- [32]Ritland Politz J.C. Zhang F. Pederson T. MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cells Proc. Natl. Acad. Sci. 103 2006 18957 18962 17135348 PMC1748159
- [33]Foldes-Papp Z. Konig K. Studier H. Buckle R. Breunig H.G. Uchugonova A. Kostner G.M. Trafficking of mature miRNA-122 into the nucleus of live liver cells Curr. Pharm. Biotechnol. 10 2009 569 578 19619125
- [34]Lin C.C. Liu L.Z. Addison J.B. Wonderlin W.F. Ivanov A.V. Ruppert J.M. A KLF4–miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context Mol. Cell. Biol. 31 2011 2513 2527 21518959 PMC3133414
- [35]Majid S. Dar A.A. Saini S. Yamamura S. Hirata H. Tanaka Y. Deng G. Dahiya R. MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer Cancer 116 2010 5637 5649 20737563 PMC3940365
- [36]Vickers K.C. Palmisano B.T. Shoucri B.M. Shamburek R.D. Remaley A.T. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins Nat. Cell Biol. 13 2011 423 433 21423178 PMC3074610
Cited by
Sorted by citations
An integrated expression atlas of miRNAs and their promoters in human and mouse
The FANTOM Consortium, de Rie, D., Abugessaisa, I., Alam, T., Arner, E., Arner, P., Ashoor, H., Åström, G., Babina, M., Bertin, N., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3947 · Cited by 561 · see citing works
- Authors
- Vinod, M., Chennamsetty, I., Colin, S., Belloy, L., De Paoli, F., Schaider, H., Graier, W. F., Frank, S., Kratky, D., Staels, B., Chinetti-Gbaguidi, G., & Kostner, G. M.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 1841
- Issue
- 6
- Pages
- 827-835
- ISSN
- 1388-1981
- PMC
- PMC3996726
- Cited by
- 41
- References
- 4
- Language
- en
- Funders
- PhD Program in Molecular Medicine of the Medical University of Graz
- Austrian Science Fund (DK-MCD W1226, SFB-LIPOTOX F30, P22832)
- Marietta Blau Scholarship (OeAD)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review