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The isoprostanes—25 years later
Open accessAbstract
Isoprostanes (IsoPs) are prostaglandin-like molecules generated independent of the cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first isoprostane species discovered were isomeric to prostaglandin F2α and were thus termed F2-IsoPs. Since the initial discovery of the F2-IsoPs, IsoPs with differing ring structures have been identified as well as IsoPs from different polyunsaturated fatty acids, including eicosapentaenoic acid and docosahexanenoic acid. The discovery of these molecules in vivo in humans has been a major contribution to the field of lipid oxidation and free radical research over the course of the past 25 years. These molecules have been determined to be both biomarkers and mediators of oxidative stress in numerous disease settings. This review focuses on recent developments in the field with an emphasis on clinical research. Special focus is given to the use of IsoPs as biomarkers in obesity, ischemia-reperfusion injury, the central nervous system, cancer, and genetic disorders. Additionally, attention is paid to diet and lifestyle factors that can affect endogenous levels of IsoPs. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance."
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“Isoprostanes are specific prostaglandin-like molecules formed by the non-enzymatic ROS-mediated peroxidation of PUFAs, involving for example arachidonic acid (Milne et al. 2015).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Milne et al. 2015
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“Increased amounts of F2-IsoPs are detected in cardiovascular diseases and other clinical conditions (Milne et al. 2015).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Milne et al. 2015
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
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Clinical Relevance of Biomarkers of Oxidative Stress
Frijhoff, J., Winyard, P. G., Žarković, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E., Oettrich, J., Ruskovska, T., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6317 · Cited by 918
Metadata
- Authors
- Milne, G. L., Dai, Q., & Roberts, L. J.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Roberts, L. Jackson
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 1851
- Issue
- 4
- Pages
- 433-445
- ISSN
- 1388-1981 (ISSN-L)
- PMC
- PMC5404383
- OpenAlex
- W2059867409
- Cited by
- 335
- References
- 238
- Citations by year
- 2026: 20 · 2025: 20 · 2024: 17 · 2023: 26 · 2022: 30 · 2021: 37 · 2020: 39 · 2019: 37 · 2018: 31 · 2017: 31 · 2016: 34 · 2015: 13
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- GM15431
- ES000267
- CA106591
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- isoprostanes, lipid peroxidation, arachidonic acid, free radicals, oxidative stress, biomarkers, F2-isoprostanes, eicosapentaenoic acid, docosahexaenoic acid, obesity, ischemia-reperfusion injury, central nervous system, cancer, genetic disorders, diet and lifestyle, polyunsaturated fatty acids
- MeSH terms
- Animals, Disease, Humans, Structure-Activity Relationship, Lipid Peroxidation, Molecular Structure, Signal Transduction, Biomarkers, Oxidative Stress, Isoprostanes
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