Obesity and Systemic Oxidative Stress: Clinical Correlates of Oxidative Stress in The Framingham Study
Abstract
Objective— To determine the clinical conditions associated with systemic oxidative stress in a community-based cohort. Information regarding cardiovascular risk factors associated with systemic oxidative stress has largely been derived from highly selected samples with advanced stages of vascular disease. Thus, it has been difficult to evaluate the relative contribution of each cardiovascular risk factor to systemic oxidative stress and to determine whether such risk factors act independently and are applicable to the general population. Methods and Results— We examined 2828 subjects from the Framingham Heart Study and measured urinary creatinine–indexed levels of 8-epi-PGF 2α as a marker of systemic oxidative stress. Age- and sex-adjusted multivariable regression models were used to assess clinical correlates of oxidative stress. In age- and sex-adjusted models, increased urinary creatinine–indexed 8-epi-PGF 2α levels were positively associated with female sex, hypertension treatment, smoking, diabetes, blood glucose, body mass index, and a history of cardiovascular disease. In contrast, age and total cholesterol were negatively correlated with urinary creatinine–indexed 8-epi-PGF 2α levels. After adjustment for several covariates, decreasing age and total/HDL cholesterol ratio, sex, smoking, body mass index, blood glucose, and cardiovascular disease remained associated with urinary 8-epi-PGF 2α levels. Conclusions— Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF 2α levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease.
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A positive relationship between various anthropometric parameters of obesity and plasma levels of IL-6 has been described for men and postmenopausal women.
“A positive relationship between various anthropometric parameters of obesity and plasma levels of IL-6 has been described for men and postmenopausal women (estrogens are known to inhibit IL-6 secretion) [102,103,104].”
From Iron Deficiency in Obesity and after Bariatric Surgery (2021) · cites this paper as [104]
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- Authors
- Keaney, J. F., Larson, M. G., Vasan, R. S., Wilson, P. W. F., Lipinska, I., Corey, D., Massaro, J. M., Sutherland, P., Vita, J. A., & Benjamin, E. J.
- Affiliations
- Boston University (US)
- ORCID
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2003-03
- Volume
- 23
- Issue
- 3
- Pages
- 434-439
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2131398405
- Cited by
- 1,304
- References
- 39
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 27 · 2023: 30 · 2022: 44 · 2021: 52 · 2020: 44 · 2019: 45 · 2018: 51 · 2017: 67 · 2016: 71 · 2015: 82 · 2014: 74 · 2013: 97 · 2012: 93
- FWCI
- 32.81
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-03-15)
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association (N01-HC-25195)
- National Institutes of Health (5r01dk055656-03, n01hc025195-11-0-0, n01hv28178-12-0-0, N01-HC 25195, DK55656)
- National Heart, Lung, and Blood Institute (P01HL060886, N01 HV28178, N01‐HC25195, K24HL004334, HL71039, R01HL064753, HL64753, HL-60886, R01HL071039, HL04334)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-55656)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- systemic oxidative stress, obesity, 8-isoprostane, urinary biomarkers, body mass index, diabetes mellitus, smoking, hypertension, cardiovascular risk factors, cardiovascular disease, Framingham Heart Study
- MeSH terms
- Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Obesity, Risk Factors, Sex Factors, Smoking, Dinoprost, Comorbidity, Body Mass Index, Multivariate Analysis, Oxidative Stress, F2-Isoprostanes
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