Cited by 225Lipid metabolism and biosynthesisAlgal biology and biofuel productionMicrobial Metabolic Engineering and Bioproduction

The DOI matches its Crossref record; 146 of the 148 references it cites were found in a registry or an index.

Stress-induced neutral lipid biosynthesis in microalgae — Molecular, cellular and physiological insights

Open access

Zienkiewicz, Krzysztof, Du, Zhi-Yan, Ma, Wei, Vollheyde, Katharina, Benning, Christoph·2016·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/j.bbalip.2016.02.008

Open this paper in CoChat — free account

Abstract

Photosynthetic microalgae have promise as biofuel feedstock. Under certain conditions, they produce substantial amounts of neutral lipids, mainly in the form of triacylglycerols (TAGs), which can be converted to fuels. Much of our current knowledge on the genetic and molecular basis of algal neutral lipid metabolism derives mainly from studies of plants, i.e. seed tissues, and to a lesser extent from direct studies of algal lipid metabolism. Thus, the knowledge of TAG synthesis and the cellular trafficking of TAG precursors in algal cells is to a large extent based on genome predictions, and most aspects of TAG metabolism have yet to be experimentally verified. The biofuel prospects of microalgae have raised the interest in mechanistic studies of algal TAG biosynthesis in recent years and resulted in an increasing number of publications on lipid metabolism in microalgae. In this review we summarize the current findings on genetic, molecular and physiological studies of TAG accumulation in microalgae. Special emphasis is on the functional analysis of key genes involved in TAG synthesis, molecular mechanisms of regulation of TAG biosynthesis, as well as on possible mechanisms of lipid droplet formation in microalgal cells. This article is part of a Special Issue entitled: Plant Lipid Biology edited by Kent D. Chapman and Ivo Feussner.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbalip.2016.02.008

Cites

146 of 146 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Biodiesel from microalgae
Chisti, Y. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2007.02.001 · Cited by 9,524
Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
Hu, Q., Sommerfeld, M., Jarvis, E., Ghirardi, M., Posewitz, M., Seibert, M., & Darzins, A. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03492.x · Cited by 3,745
The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions
Merchant, S., Prochnik, S. E., Vallon, O., Harris, E. H., Karpowicz, S. J., Witman, G. B., Terry, A., Salamov, A. A., Fritz‐Laylin, L. K., Maréchal‐Drouard, L., et al. (2007) · Science · doi:10.1126/science.1143609 · Cited by 2,703
The Phaeodactylum genome reveals the evolutionary history of diatom genomes
Bowler, C., Allen, A. E., Badger, J. H., Grimwood, J., Jabbari, K., Kuo, A., Maheswari, U., Martens, C., Maumus, F., Otillar, R., et al. (2008) · Nature · doi:10.1038/nature07410 · Cited by 1,719
Handbook of Plant and Crop Stress
Pessarakli, M. (1999) · CRC Press eBooks · doi:10.1201/9780824746728 · Cited by 1,327
Genetic Engineering of Algae for Enhanced Biofuel Production
Radakovits, R., Jinkerson, R. E., Darzins, A., & Posewitz, M. C. (2010) · Eukaryotic Cell · doi:10.1128/ec.00364-09 · Cited by 1,142
Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
Yen, C.-L. E., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800018-jlr200 · Cited by 1,105
Genome analysis of the smallest free-living eukaryote Ostreococcus tauri unveils many unique features
Derelle, É., Ferraz, C., Rombauts, S., Rouzé, P., Worden, A. Z., Robbens, S., Partensky, F., Degroeve, S., Echeynié, S., Cooke, R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604795103 · Cited by 893
Phospholipid:diacylglycerol acyltransferase: An enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants
Dahlqvist, A., Ståhl, U., Lenman, M., Banaś, A., Lee, M. A., Sandager, L., Ronne, H., & Stymne, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120067297 · Cited by 883
Oil accumulation in the model green alga Chlamydomonas reinhardtii: characterization, variability between common laboratory strains and relationship with starch reserves
Siaut, M., Cuiné, S., Cagnon, C., Fessler, B., Nguyen, H. M., Carrier, P., Beyly, A., Beisson, F., Triantaphylidès, C., Li‐Beisson, Y., et al. (2011) · BMC Biotechnology · doi:10.1186/1472-6750-11-7 · Cited by 754

Flagged first, then by citations

Show all 148 references

2 of the 148 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Panchy, 2014, 4, 2461
El-Hafid, 1989, Enzymatic breakdown of polar lipids in cotton leaves under water stress: I. Degradation of monogalactosyl-diacylglycerol, Plant Physiol. Biochem., 27, 495

Sorted by citations

Items 101–200 of 224

Lipid Droplets from Plants and Microalgae: Characteristics, Extractions, and Applications
Xu, K., Zou, W., Peng, B., Guo, C., & Zou, X. (2023) · Biology · doi:10.3390/biology12040594 · Cited by 20
Improved productivity and oxidative stress tolerance under nitrogen starvation is associated with the ablated Δ5 desaturation in the green microalga Lobosphaera incisa
Pal‐Nath, D., Didi‐Cohen, S., Shtaida, N., Nath, P. R., Samani, T., Boussiba, S., & Khozin‐Goldberg, I. (2017) · Algal Research · doi:10.1016/j.algal.2017.06.026 · Cited by 18
Fucoxanthin and docosahexaenoic acid production by cold-adapted Tisochrysis lutea
Gao, F., Cabanelas, I. T. D., Wijffels, R. H., & Barbosa, M. J. (2021) · New Biotechnology · doi:10.1016/j.nbt.2021.08.005 · Cited by 19
Cytotoxicity of BP-3 and BP-4: Blockage of extrusion pumps, oxidative damage and programmed cell death on Chlamydomonas reinhardtii.
Anido-Varela, L., Seoane, M., Esperanza, M., Cid, Á., & Rioboo, C. (2022) · Aquatic Toxicology · doi:10.1016/j.aquatox.2022.106285 · Cited by 15
Genome-wide characterization and expression profiling of diacylglycerol acyltransferase genes from maize
Yan, B., Xu, X., Gu, Y., Ying, Z., Zhao, X., He, L., Zhao, C., Li, Z., & Xu, J. (2018) · Genome · doi:10.1139/gen-2018-0029 · Cited by 16
Utilizing co-cultivation of Tetraselmis chuii and Chlorella vulgaris to improve high-value biomass yield in dairy wastewater treatment
Mahdavi, S., & Tavakoli, O. (2025) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2025.107572 · Cited by 19
Revealing mechanisms of algal astaxanthin production and bioengineering potential using multiomics
Jeffers, T. L., & Roth, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823304-7.00010-6 · Cited by 16
Influence of photoperiod, light illumination, and pH on total lipids, triacylglycerol content, saturated and unsaturated fatty acid levels in the microalga Chlorella vulgaris for biodiesel
Alharbi, R. M., Mathivanan, K., Ravi, G., & Rakesh, E. (2024) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2024.103144 · Cited by 17
ROS and Ca2+ signaling involved in important lipid changes of Chlorella pyrenoidosa under nitrogen stress conditions
Wang, L., Shi, Q., Pan, Y., Shi, L., & Huang, X. (2024) · Planta · doi:10.1007/s00425-024-04471-6 · Cited by 15
Manipulation of triacylglycerol biosynthesis in Nannochloropsis oceanica by overexpressing an Arabidopsis thaliana diacylglycerol acyltransferase gene
Zhang, L., Wang, S., Han, J., Yang, G., Pan, K., & Xu, J. (2021) · Algal Research · doi:10.1016/j.algal.2021.102590 · Cited by 14
MicroRNA Expression Profile Analysis of Chlamydomonas reinhardtii during Lipid Accumulation Process under Nitrogen Deprivation Stresses
Zhang, J., Shi, J., Yuan, C., Liu, X., Du, G., Fan, R., & Zhang, B. (2021) · Bioengineering · doi:10.3390/bioengineering9010006 · Cited by 14
Arabidopsis membrane protein AMAR1 interaction with type III effector XopAM triggers a hypersensitive response
Xie, Q., Wei, B., Zhan, Z., He, Q., Wu, K., Chen, Y., Liu, S., He, C., Niu, X., Li, C.-F., et al. (2023) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiad478 · Cited by 14
Characterization of a uranium-tolerant green microalga of the genus Coelastrella with high potential for the remediation of metal-polluted waters
Beaulier, C., Dannay, M., Devime, F., Galeone, A., Baggio, C., El‐Sakkout, N., Raillon, C., Courson, O., Bourguignon, J., Alban, C., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.168195 · Cited by 16
Comparative energetics of carbon storage molecules in green algae
McKie-Krisberg, Z. M., Laurens, L. M. L., Huang, A., & Polle, J. E. W. (2018) · Algal Research · doi:10.1016/j.algal.2018.01.018 · Cited by 14
The ΔF/Fm′-guided supply of nitrogen in culture medium facilitates sustainable production of TAG in Nannochloropsis oceanica IMET1
Liu, J., Yao, C., Meng, Y., Cao, X., Wu, P., & Xue, S. (2018) · Biotechnology for Biofuels · doi:10.1186/s13068-018-1168-y · Cited by 14
Chloroplasts Isolation from Chlamydomonas reinhardtii under Nitrogen Stress
Yang, M., Jiang, J., Xie, X., Chu, Y., Fan, Y., Cao, X., Xue, S., & Chi, Z. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01503 · Cited by 14
Exploring microalgae-based biodiesel as an alternative fuel: Development, production techniques and environmental impacts
Chaudhary, S., Bano, K. S., Mohanty, T., Kumari, A., & Mehdi, M. M. (2025) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2025.108249 · Cited by 14
Microalgae for sustainable biodiesel and omega-3: A comprehensive review of production, processing, and implementation
Michael, M., Vanness, V., Henry, H., Tjandra, T. M., Kristian, K., Nasution, J. A., Masytha, M., Sidabutar, R., Trisakti, B., Irvan, I., et al. (2025) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2025.116327 · Cited by 16
Lipid remodeling in phytoplankton exposed to multi-environmental drivers in a mesocosm experiment
Cantarero, S. I., Flores, E., Allbrook, H., Aguayo, P., Vargas, C. A., Tamanaha, J. E., Scholz, J., Bach, L. T., Löscher, C. R., Riebesell, U., et al. (2024) · Biogeosciences · doi:10.5194/bg-21-3927-2024 · Cited by 13
Glutathione peroxidase 5 deficiency induces lipid metabolism regulated by reactive oxygen species in Chlamydomonas reinhardtii
Ma, X., Wei, H., Zhang, Y., Duan, Y., Zhang, W., Cheng, Y., Xia, X.-Q., & Shi, M. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104358 · Cited by 12
Enhancing immobilized Chlorella vulgaris growth with novel buoyant barium alginate bubble beads
Liu, Y. C., Zhang, G., Li, Y., Wu, X., Shang, S., & Che, W. (2024) · Bioresource Technology · doi:10.1016/j.biortech.2024.130996 · Cited by 11
Isolation and Characterization of Microalgae from Diverse Pakistani Habitats: Exploring Third-Generation Biofuel Potential
Alam, M. M., Mumtaz, A. S., Russell, M., Grogger, M. L. M., Veverka, D., & Hallenbeck, P. C. (2019) · Energies · doi:10.3390/en12142660 · Cited by 12
Effect of the streptomycin removal process on metabolite profile of Chlamydomonas reinhardtii: the potential of antibiotic stress on lipid production for biodiesel
Yıldırım, A. (2024) · Journal of Applied Phycology · doi:10.1007/s10811-024-03393-w · Cited by 10
Lipid and Fatty Acids Accumulation Features of Entomoneis cf. paludosa during Exponential and Stationary Growth Phases in Laboratory Culture
Bedoshvili, Y. D., Podunay, Y. А., Nikonova, A. A., Marchenkov, A., Bairamova, E., Давидович, Н. А., & Likhoshway, Y. V. (2021) · Diversity · doi:10.3390/d13100459 · Cited by 10
Exogenous ethanol induces cell giantism accompanied by enhanced accumulation of lipid and carbohydrates in Chlorella sorokiniana
Abate, R., Bi, Y., Song, G., Mi, W., Cheng, F., & Zhu, Y. (2024) · Journal of Applied Phycology · doi:10.1007/s10811-024-03199-w · Cited by 9
Cultivation of Chlorella vulgaris in wastewater: biodiesel potential and wastewater remediation
Sarpal, A. S., Teixeira, C. M. L. L., & Costa, I. C. R. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-34231-8 · Cited by 9
Advanced Gene Technology and Synthetic Biology Approaches to Custom Design Microalgae for Biodiesel Production
Arora, N., Tripathi, S., Poluri, K. M., & Pruthi, V. (2019) · Springer eBooks · doi:10.1007/978-981-13-2264-8_8 · Cited by 9
A review of marine microalgae-based lipids production: biosynthesis, technological advancements, and practical applications
Yang, L., Duan, B., & Lu, Q. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1664674 · Cited by 9
Metabolomic Study of Heterotrophically Grown Chlorella sp. Isolated from Wastewater in Northern Sweden
Nzayisenga, J. C., & Sellstedt, A. (2021) · Molecules · doi:10.3390/molecules26092410 · Cited by 8
Differences in Glycerolipid Response of Chlamydomonas reinhardtii Starchless Mutant to High Light and Nitrogen Deprivation Stress Under Three Carbon Supply Regimes
Yang, M., Xie, X., Kong, F., Xie, K., Yu, S., Ma, J.-Y., Xue, S., & Gong, Z. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.860966 · Cited by 8
Propanol and 1, 3-propanediol enhance fatty acid accumulation synergistically in Schizochytrium ATCC 20888
Wang, T., Wang, F., Zeng, L., Guo, P., Wu, Y., Chen, L., & Zhang, W. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1106265 · Cited by 8
DGAT1 from the arachidonic-acid-producing microalga Lobosphaera incisa shows late gene expression under nitrogen starvation and substrate promiscuity in a heterologous system
Sitnik, S., Shtaida, N., Guihéneuf, F., Leu, S., Popko, J., Feußner, I., Boussiba, S., & Khozin‐Goldberg, I. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1364-3 · Cited by 8
Manipulation of Microalgal Lipid Production: A Genetic Engineering Aspect
Foo, S. C., Khong, N. M. H., & Yusoff, F. M. (2019) · Springer eBooks · doi:10.1007/978-981-13-2264-8_9 · Cited by 8
Circadian protein regulation in the green lineage I. A phospho-dawn of protein modification anticipates light onset in the picoeukaryote O. tauriPreprint
Noordally, Z. B., Hindle, M., Martin, S. F., Seaton, D. D., Simpson, T. I., Bihan, T. L., & Millar, A. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/287862 · Cited by 8
Stimulation of microalgae growth and high-value compounds production by magnetic field exposure
López-Bello, E., Vargas-Estrada, L., Aizpuru, A., Arriaga, S., & Muñoz, R. (2025) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2025.119171 · Cited by 7
Biofuel Production: Global Scenario and Future Challenges
Mahapatra, M. K., & Kumar, A. (2020) · Biofuel and biorefinery technologies · doi:10.1007/978-3-030-53933-7_16 · Cited by 7
Microalgal Neutral Lipid Accumulation: Cellular Mechanism and Ways to Improve Biodiesel Production
Sreelakshmi, M., & Arunkumar, K. (2025) · BioEnergy Research · doi:10.1007/s12155-025-10851-x · Cited by 7
Plastidic membrane lipids are oxidized by a lipoxygenase in Lobosphaera incisa
Djian, B., Feussner, K., Herrfurth, C., Zienkiewicz, K., Hornung, E., & Feußner, I. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1102215 · Cited by 7
Self-citation
Ostreococcus tauri is a high-lipid content green algae that extrudes clustered lipid dropletsPreprint
Smallwood, C., Chrisler, W., Chen, J.-H., Patello, E., Thomas, M., Boudreau, R., Ekman, A. A., Wang, H., McDermott, G., & Evans, J. E. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/249052 · Cited by 7
Polyunsaturated triacylglycerol accumulation mainly attributes to turnover of de novo-synthesized membrane lipids in stress-induced starchless Chlamydomonas
Yang, M., Xu, X., Lei, H., Yang, Z., Xie, X., & Gong, Z. (2024) · Plant Cell Reports · doi:10.1007/s00299-024-03334-4 · Cited by 6
A phospho-dawn of protein modification anticipates light onset in the picoeukaryoteOstreococcus tauri
Noordally, Z. B., Hindle, M., Martin, S. F., Seaton, D. D., Simpson, T. I., Bihan, T. L., & Millar, A. J. (2023) · Journal of Experimental Botany · doi:10.1093/jxb/erad290 · Cited by 12
Combined application of nitrogen, phosphorus, iron, and silicon improves growth and fatty acid composition in marine epiphytic diatoms
Yang, M., Xu, X., Hu, H., Zhang, W.-D., Ma, J.-Y., Lei, H.-P., Wang, Q., Xie, X., & Gong, Z. (2023) · Frontiers in Marine Science · doi:10.3389/fmars.2023.1292713 · Cited by 6
Fatty Acid Production and Direct Acyl Transfer through Polar Lipids Control TAG Biosynthesis during Nitrogen Deprivation in the Halotolerant Alga Dunaliella tertiolecta
Avidan, O., Malitsky, S., & Pick, U. (2021) · Marine Drugs · doi:10.3390/md19070368 · Cited by 6
Limited fatty-acid supply from the plastid and active catabolism of triacylglycerol prevent the accumulation of triacylglycerol in Coccomyxa sp. strain Obi grown under nitrogen-replete conditions
Oyama, K., Matsuwaki, I., Ito, M., Iwahori, R., Nagata, H., Nakamura, I., Kondo, A., Kodaka, A., Fuseya, Y., Yamamoto, H., et al. (2022) · Algal Research · doi:10.1016/j.algal.2021.102620 · Cited by 6
Pavlova gyrans as a potential source of essential fatty acids, sterols and pigments: culture under low temperature
Almeyda, M. D., Bilbao, P., Sanchez-Puerta, M. V., Constenla, D. T., & Leonardi, P. I. (2023) · Journal of Applied Phycology · doi:10.1007/s10811-023-02943-y · Cited by 7
Glycerolipid remodeling is crucial for acclimation to naphthenic acid exposure in Chlorella pyrenoidosa and Chlamydomonas reinhardtii
Yang, M., Ma, J.-Y., Yu, S., Xie, K., Zhang, W., Zhang, E., Wang, Q., Xie, X., & Gong, Z. (2023) · Algal Research · doi:10.1016/j.algal.2023.103098 · Cited by 6
Sub-lethal toxicity of five disinfection by-products on microalgae determined by flow cytometry – Lines of evidence for adverse outcome pathways
Ciccia, T., Pandard, P., Ciffroy, P., Urien, N., Lafay, L., & Bado‐Nilles, A. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115582 · Cited by 6
Can 2, 4-dichlorophenoxyacetic acid alter growth performance, biochemical composition, and fatty acid profile of the marine microalga Isochrysis galbana?
Madani, N. S. H., Shekarabi, S. P. H., Mehrgan, M. S., & Pourang, N. (2020) · Phycologia · doi:10.1080/00318884.2020.1827826 · Cited by 5
Enhancing lipid accumulation in marine microalgae for sustainable biofuel applications: A review of Nannochloropsis and Tetraselmis
Doan, L., Tran, A. Q. V., Ong, Q. K. L., Huynh, K. G., Tran, K., & Phung, T. K. (2026) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2026.109210 · Cited by 4
Effects of Phloretin on Seedling Growth and Histochemical Distribution of Phenols, Polysaccharides and Lipids in Capsella bursa-pastoris (L.) Medik.
Đorđić, M., Janošević, D. A., Smailagić, D., Banjac, N., Ninković, S., Stanišić, M., & Trajković, M. (2024) · Plants · doi:10.3390/plants13141890 · Cited by 4
Functional characterization of the plastidial enzyme GPAT in microalgae and its potential role in lipid biosynthesis
Chen, H., Ma, H., Yu, L., Zou, S., Li, Y., Lu, Y., Yang, M., Ge, F., Yuan, L., Zeng, X., et al. (2025) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiaf395 · Cited by 4
A Novel Bifunctional Wax Ester Synthase Involved in Early Triacylglycerol Accumulation in Unicellular Green Microalga Haematococcus pluvialis Under High Light Stress
Ma, H., Zheng, J., Li, Y., Zhao, L., Zou, S., Hu, Q., & Han, D. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.794714 · Cited by 5
Cyclic and pseudo-cyclic electron pathways play antagonistic roles during nitrogen deficiency in Chlamydomonas reinhardtii
Dao, O., Burlacot, A., Buchert, F. E., Bertrand, M., Auroy, P., Stoffel, C., Madireddi, S. K., Irby, J. R., Hippler, M., Peltier, G., et al. (2024) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiae617 · Cited by 4
Review of bioenergy systems
Darra, R., Tawalbeh, M., Ali, A. M., Asaad, S. M., & Al–Othman, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95211-8.00019-1 · Cited by 4
Lipid Droplets in Endosymbiotic Symbiodiniaceae spp. Associated with Corals
Pasaribu, B., Purba, N. P., Dewanti, L. P., Pasaribu, D., Khan, A. M. A., Harahap, S. A., Syamsuddin, M. L., Ihsan, Y. N., Siregar, S. H., Faizal, I., et al. (2024) · Plants · doi:10.3390/plants13070949 · Cited by 4
Bioenergy from Microalgae – Vision or Reality?
Hoyer, J., Cotta, F., Diete, A., & Großmann, J. (2018) · ChemBioEng Reviews · doi:10.1002/cben.201800007 · Cited by 4
Membrane Homeostasis upon Nutrient (C, N, P) Limitation
Schubotz, F. (2018) · Springer eBooks · doi:10.1007/978-3-319-43676-0_59-1 · Cited by 4
Comparative lipidomic analysis of Chlorella stigmatophora and Hemiselmis cf. andersenii in response to nitrogen-induced changes
Fernandes, T., Ferreira, A. R., & Cordeiro, N. (2021) · Algal Research · doi:10.1016/j.algal.2021.102417 · Cited by 4
Plant lipid biology
Chapman, K. D., & Feußner, I. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.05.005 · Cited by 4
Microalgae for Biodiesel Production
Adetunji, C. O., Adenigba, V. O., Thangadura, D., & Ahamed, M. I. (2021) · Wiley eBooks · doi:10.1002/9781119724957.ch16 · Cited by 4
Algal lipids, lipidomics, and biosurfactants
Reddy, M. M. S., Tiwari, S., & Chauhan, V. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18816-9.00019-8 · Cited by 3
Cellular signaling pathways with reactive oxygen species (ROS)
Madkour, L. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-822481-6.00003-7 · Cited by 3
Temperature and nutrient coupled stress on microalgal neutral lipids for low‐carbon fuels production
Anandraj, A., White, S., & Bwapwa, J. K. (2021) · Biofuels Bioproducts and Biorefining · doi:10.1002/bbb.2221 · Cited by 2
Lipid metabolism and metabolic engineering of eukaryotic microalgae
Zhang, Y., & Liu, J. (2021) · Advances in bioenergy · doi:10.1016/bs.aibe.2021.05.001 · Cited by 2
Exploring the NMR Metabolic Landscape of Chrysochromulina rotalis: The Impact of Photobioreactor Configurations and Culture Conditions
Abreu, A. C., la Rosa, A. M.-D., Tristán, A. I., López‐Rosales, L., Salmerón, A. D. M., Sánchez‐Mirón, A., García-Camacho, F., Cerón-García, M. C., & Fernández, I. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c00160 · Cited by 1
Lipids, fatty acids, and sterols from microalgae
Vendruscolo, R. G., & Fagundes, M. B. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22080-7.00031-4 · Cited by 1
Further evidence supporting the existence and accumulation of triacylglycerol and acylplastoquinol in cyanobacteria
Sato, N., Jimbo, H., Yoshitomi, T., Shoji, T., Sato, M., Takeda‐Kamiya, N., Toyooka, K., & Wada, H. (2025) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiaf478 · Cited by 1
The toxicological effects of low-density polyethylene microplastic particles (LDPE-MPs) on the growth and metabolic activities of the marine diatom Chaetoceros muellerii
Marey, R. S., Abo-Shady, A. M., Khairy, H. M., Shabaka, S. H., & Ismail, G. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-27440-9 · Cited by 1
Advances in Microbial Fuel Cells Using Carbon-Rich Wastes as Substrates
Ren, K., Wang, J., Hou, X., Huang, J., & Liu, S. (2026) · Processes · doi:10.3390/pr14030416 · Cited by 1
Bioinformatic Analyses of the Ataxin-2 Family Since Algae Emphasize Its Small Isoforms, Large Chimerisms, and the Importance of Human Exon 1B as Target of Therapies to Prevent Neurodegeneration
Auburger, G. W. J., Key, J., Gispert, S., Lastres‐Becker, I., Almaguer-Mederos, L.-E., Bassa, C., Auburger, A., Auburger, G. W. J., Arsović, A., Deller, T., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031499 · Cited by 2
Bioenergy from Microalgae – Vision or Reality?
Hoyer, J., Cotta, F., Diete, A., & Großmann, J. (2017) · Chemie Ingenieur Technik · doi:10.1002/cite.201700085 · Cited by 1
Consequences of Oxidative Stress and ROS-Mediated Pathways Cellular Signaling Stress Response
Madkour, L. H. (2020) · Nanomedicine and nanotoxicology · doi:10.1007/978-3-030-37297-2_5 · Cited by 1
Characterization of Acyltransferases in Neutral Lipid Synthesis
Vollheyde, K. (2021) · doi:10.53846/goediss-8569 · Cited by 1
Self-citation
Biogenesis of Lipid Bodies in Lobosphaera incisa
Siegler, H. (2017) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6156 · Cited by 1
Réponses physiologiques et biochimiques à une limitation nutritive en phosphore ou en azote sur la réorientation métabolique des lipides polaires chez différentes espèces de microalgues marines
Huang, B. (2018) · theses.fr (ABES) · doi:10.70675/ed1a3316z694ez4f60zaa57z3453d734b09b · Cited by 1
Decision letter: Algal-fungal symbiosis leads to photosynthetic mycelium
Harrison, M., Bonfante, P., & Hom, E. F. Y. (2019) · eLife · doi:10.7554/elife.47815.030
Autotrophic and heterotrophic culture of Nordic microalgae in wastewater for lipid production
Nzayisenga, J. C. (2020) · DiVA at Umeå University (Umeå University)
Microalgae for combined nutrient recovery and biofuel production from sewage
Wood, N. J. (2020) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
DEVELOPING A CHLOROPHYLL-BASED PREDICTION MODEL FOR EICOSAPENTAENOIC ACID (EPA) PRODUCTION IN PHYTOPLANKTON
Cheng, M. (2020) · DalSpace (Dalhousie University)
Análise integrativa de proteômica, metabolômica e lipidômica para estudo da acumulação de lipídios neutros na microalga Chlamydomonas reinhardtii
Giraldi, L. A. (2021) · doi:10.11606/t.105.2021.tde-09092021-145727
Growth and lipid levels of Tetraselmis tetrahele and Nannochloropsis sp. cultured under commercial fertilizers
Gonzales-Plasus, M. M. (2020) · The Palawan Scientist · doi:10.69721/tps.j.2020.12.1.07
Protein Turnover on Plant Lipid Droplets
Kretzschmar, F. K. (2020) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7946
Effects of Microplastics on Algae in Receiving Waters
Wang, D., Fu, Q., and, X. L., & Liu, X. (2022) · doi:10.1002/9781119759379.ch9
Methods for the localization of cellular components in Chlamydomonas
Silflow, C. D., Mackinder, L. C. M., & Wingfield, J. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-822457-1.00003-0
Gene expression and lipid accumulation in green microalga chlamydomonas reinhardtii (137c) under salt stress condition
Atikij, T., & Waditee-Sirisattha, R. (2018) · doi:10.58837/chula.the.2018.369
Comment on egusphere-2023-3110
(2024) · doi:10.5194/egusphere-2023-3110-rc1
Comment on egusphere-2023-3110
(2024) · doi:10.5194/egusphere-2023-3110-rc2
Comment on egusphere-2023-3110
(2024) · doi:10.5194/egusphere-2023-3110-rc3
Reply on RC3
(2024) · doi:10.5194/egusphere-2023-3110-ec3
Reply on RC2
(2024) · doi:10.5194/egusphere-2023-3110-ec2
Reply on RC1
(2024) · doi:10.5194/egusphere-2023-3110-ec1
Caractérisation des glycérolipides et de la dynamique de remodelage en chaines acyles chez Ostreococcus tauri
Degraeve-Guilbault, C. (2017) · theses.fr (ABES) · doi:10.70675/b737f152zc60fz42f2z9875zfd46ea0d165b
Reply on RC2
Flores, E. (2024) · doi:10.5194/egusphere-2023-3110-ac2
Reply on RC3
Flores, E. (2024) · doi:10.5194/egusphere-2023-3110-ac3
Reply on RC1
Flores, E. (2024) · doi:10.5194/egusphere-2023-3110-ac1
Additional file 2 of AP2/ERF and R2R3-MYB family transcription factors: potential associations between temperature stress and lipid metabolism in Auxenochlorella protothecoides
Xing, G., Li, J., Li, W., Lam, S. M., Yuan, H., Shui, G., & Yang, J. (2021) · Figshare · doi:10.6084/m9.figshare.13585512
Algal Biocrude as Drop-In Feedstock for Green Fuel and Green Chemicals
Bhujade, R., & Agrawal, P. S. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815196740124060008
Additional file 1 of AP2/ERF and R2R3-MYB family transcription factors: potential associations between temperature stress and lipid metabolism in Auxenochlorella protothecoides
Xing, G., Li, J., Li, W., Lam, S. M., Yuan, H., Shui, G., & Yang, J. (2021) · Figshare · doi:10.6084/m9.figshare.13585509
Additional file 3 of AP2/ERF and R2R3-MYB family transcription factors: potential associations between temperature stress and lipid metabolism in Auxenochlorella protothecoides
Xing, G., Li, J., Li, W., Lam, S. M., Yuan, H., Shui, G., & Yang, J. (2021) · Figshare · doi:10.6084/m9.figshare.13585515
Additional file 3 of Overexpression of an endogenous type 2 diacylglycerol acyltransferase in the marine diatom Phaeodactylum tricornutum enhances lipid production and omega-3 long-chain polyunsaturated fatty acid content
Haslam, R. P., Hamilton, M. L., Economou, C. K., Smith, R., Hassall, K. L., Napier, J. A., & Sayanova, O. V. (2020) · Figshare · doi:10.6084/m9.figshare.12307958

Authors: Zienkiewicz, K., Du, Z.-Y., Ma, W., Vollheyde, K., & Benning, C.
Affiliations: University of Göttingen (DE)
Michigan State University (US)
Great Lakes Bioenergy Research Center (US)
ORCID: Zienkiewicz, Krzysztof
Du, Zhi-Yan
Ma, Wei
Vollheyde, Katharina
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 2016-09
Volume: 1861
Issue: 9
Pages: 1269-1281
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/j.bbalip.2016.02.008
OpenAlex: W2258753467
Cited by: 225
References: 148
Citations by year: 2026: 15 · 2025: 12 · 2024: 23 · 2023: 17 · 2022: 10 · 2021: 30 · 2020: 38 · 2019: 24 · 2018: 21 · 2017: 30 · 2016: 5
FWCI: 3.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 327 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (acceptedVersion)
PubMed (publishedVersion)
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
GRO (submittedVersion)
Funders: Center for Advanced Biofuels Systems (DE-SC0001295)
U.S. Department of Energy, Office of Basic Energy Sciences (DE-SC0001295)
U.S Department of Energy, Office of Basic Energy Sciences (DE-FG02-98ER20305)
US National Science Foundation (MCB-0741395, MCB-1515169)
US Department of Energy-Great Lakes Bioenergy Research Center Cooperative Agreement (DE-FC02-07ER64494)
US Air Force Office of Scientific Research (FA9550-11-1-0264)
Michigan State University AgBioResearch
Marie Curie International Outgoing Fellowship within the EU 7th Framework Program AlgaeOilSynth (627266, FP7-PEOPLE-2013-IOF)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords: microalgae, triglyceride synthesis, stress response, lipid droplet formation, lipid metabolism, biofuel feedstock
MeSH terms: Fatty Acids, Lipids, Photosynthesis, Triglycerides, Genome, Plant, Lipid Metabolism, Biofuels, Microalgae

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Stress-induced neutral lipid biosynthesis in microalgae — Molecular, cellular and physiological insights

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks