The DOI matches its Crossref record.
SC5D is the sixth enzyme in cholesterol biosynthesis targeted by the E3 ubiquitin ligase MARCHF6
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The degradation targets of MARCHF6 include other mevalonate pathway enzymes DHCR24, LDM, SC4MOL, and SC5D.
“In recent years, the degradation targets of MARCHF6 have been expanded to other enzymes in the mevalonate pathway, including DHCR24, LDM, SC4MOL, and SC5D [[25], [26], [27]].”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [25]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 17
- Sezgin, 2017, The mystery of membrane organization: composition, regulation and roles of lipid rafts, Nat. Rev. Mol. Cell Biol., 18, 361, 10.1038/nrm.2017.16 · DOI · Paper page
- Brown, 2021, Oxysterols: from physiological tuners to pharmacological opportunities, Br. J. Pharmacol., 178, 3089, 10.1111/bph.15073 · DOI
- Porter, 2011, Malformation syndromes caused by disorders of cholesterol synthesis, J. Lipid Res., 52, 6, 10.1194/jlr.R009548 · DOI · Paper page
- Gordon, 1989, High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies, Circulation, 79, 8, 10.1161/01.CIR.79.1.8 · DOI · Paper page
- Horton, 2002, SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver, J. Clin. Invest., 109, 1125, 10.1172/JCI0215593 · DOI · Paper page
- Sharpe, 2014, The UPS and downs of cholesterol homeostasis, Trends Biochem. Sci., 39, 527, 10.1016/j.tibs.2014.08.008 · DOI · Paper page
- Zelcer, 2014, The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme a reductase and the cholesterol synthesis pathway, Mol. Cell. Biol., 34, 1262, 10.1128/MCB.01140-13 · DOI · Paper page
- Qian, 2023, Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6, J. Lipid Res., 64, 10.1016/j.jlr.2023.100362 · DOI · Paper page
- Scott, 2021, The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond, Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1866
- Nishi, 2000, Ishibashi, cDNA cloning of the mammalian sterol C5-desaturase and the expression in yeast mutant, Biochim. Biophys. Acta Gene Struct. Expr., 1490, 106, 10.1016/S0167-4781(99)00248-1 · DOI
- Koczok, 2019, Subcellular localization of sterol biosynthesis enzymes, J. Mol. Histol., 50, 63, 10.1007/s10735-018-9807-y · DOI
- Tansey, 2000, Structure and regulation of mammalian squalene synthase, Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1529, 49, 10.1016/S1388-1981(00)00137-2 · DOI
- Do, 2009, Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway, Clin. Genet., 75, 19, 10.1111/j.1399-0004.2008.01099.x · DOI
- Dickson, 2023, A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis, Nat. Commun., 14, 4816, 10.1038/s41467-023-40541-1 · DOI
- Gill, 2011, Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase, Cell Metab., 13, 260, 10.1016/j.cmet.2011.01.015 · DOI · Paper page
- Galea, 2009, Special relationship between sterols and oxygen: were sterols an adaptation to aerobic life?, Free Radic. Biol. Med., 47, 880, 10.1016/j.freeradbiomed.2009.06.027 · DOI
- Guan, 1997, Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene, J. Biol. Chem., 272, 10295, 10.1074/jbc.272.15.10295 · DOI
Cited by
Sorted by citations
Sachdev, V., van Loon, N. M., Kingma, J., Ottenhoff, R., Tan, J. M. E., van den Berg, M., Duijst, S., Jongejan, A., Levels, J. H. M., Rensen, P. C. N., et al. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102379 · Cited by 1
Metadata
- Authors
- Fenton, N. M., Qian, L., Scott, N. A., Paine, E. G., Sharpe, L. J., & Brown, A. J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2024-05
- Volume
- 1869
- Issue
- 4
- Pages
- 159482
- ISSN
- 1388-1981
- Cited by
- 5
- References
- 0
- Language
- en
- Funders
- Australian Research Council
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
