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Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6
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The degradation targets of MARCHF6 include other mevalonate pathway enzymes DHCR24, LDM, SC4MOL, and SC5D.
“In recent years, the degradation targets of MARCHF6 have been expanded to other enzymes in the mevalonate pathway, including DHCR24, LDM, SC4MOL, and SC5D [[25], [26], [27]].”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [26]
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Regulation of HMG-CoA reductase in mammals and yeast
Burg, J. S., & Espenshade, P. J. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.07.002 · Cited by 303
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Sachdev, V., van Loon, N. M., Kingma, J., Ottenhoff, R., Tan, J. M. E., van den Berg, M., Duijst, S., Jongejan, A., Levels, J. H. M., Rensen, P. C. N., et al. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102379 · Cited by 1
Metadata
- Authors
- Qian, L., Scott, N. A., Capell-Hattam, I. M., Draper, E. A., Fenton, N. M., Luu, W., Sharpe, L. J., & Brown, A. J.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2023-05
- Volume
- 64
- Issue
- 5
- Pages
- 100362
- ISSN
- 0022-2275
- PMC
- PMC10176258
- Cited by
- 23
- References
- 1
- Language
- en
- Licence
- Funders
- NSW Ministry of Health
- Australian Research Council (DP170101178)
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