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Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold
Open accessAbstract
The molecular coupling of CAS and Crk in response to integrin activation is an evolutionary conserved signaling module that controls cell proliferation, survival and migration. However, when deregulated, CAS/Crk signaling also contributes to cancer progression and developmental defects in humans. Here we highlight recent advances in our understanding of how CAS/Crk complexes assemble in cells to modulate the actin cytoskeleton, and the molecular mechanisms that regulate this process. We discuss in detail the spatiotemporal dynamics of CAS/Crk assembly and how this scaffold recruits specific effector proteins that couple integrin signaling networks to the migration machinery of cells. We also highlight the importance of CAS/Crk signaling in the dual regulation of cell migration and survival mechanisms that operate in invasive cells during development and pathological conditions associated with cancer metastasis.
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Cites
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
Schlaepfer, D. D., Hanks, S. K., Hunter, T., & Geer, P. V. D. (1994) · Nature · doi:10.1038/372786a0 · Cited by 1,595
Structure, function, and biology of SHIP proteins
Rohrschneider, L. R., Fuller, J. F., Wolf, I., Liu, Y., & Lucas, D. M. (2000) · Genes & Development · doi:10.1101/gad.14.5.505 · Cited by 294
Grimsley, C. M., Kinchen, J. M., Tosello-Trampont, A.-C., Brugnera, E., Haney, L. B., Lu, M., Chen, Q., Klingele, D., Hengartner, M. O., & Ravichandran, K. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307087200 · Cited by 224
Cited by
Focal adhesion kinase: in command and control of cell motility.
Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,335
Adhesion signaling – crosstalk between integrins, Src and Rho
Huveneers, S., & Danen, E. H. J. (2009) · Journal of Cell Science · doi:10.1242/jcs.039446 · Cited by 852
Ephrin-B2 Controls Cell Motility and Adhesion during Blood-Vessel-Wall Assembly
Foo, S. S., Turner, C. J., Adams, S., Compagni, A., Aubyn, D., Kogata, N., Lindblom, P., Shani, M., Zicha, D., & Adams, R. H. (2006) · Cell · doi:10.1016/j.cell.2005.10.034 · Cited by 441
Semaphorin Regulation of Cellular Morphology
Tran, T. S., Kolodkin, A. L., & Bharadwaj, R. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010605.093554 · Cited by 388
p130Cas: a versatile scaffold in signaling networks
Defilippi, P., Di Stefano, P., & Cabodi, S. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.03.003 · Cited by 326
Metadata
- Authors
- Chodniewicz, D., & Klemke, R. L.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 1692
- Issue
- 2-3
- Pages
- 63-76
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W1999916818
- Cited by
- 190
- References
- 3
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chodniewicz, D., & Klemke, R. L. (2004). Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2004.03.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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