FAK-independent αvβ3 integrin-EGFR complexes rescue from anoikis matrix-defective fibroblasts
Open accessAbstract
Extracellular matrix (ECM) binding to integrin receptors regulates cell cycle progression and survival. In adherent cells, ECM disassembly induces anoikis, the apoptotic pathway switched on by loss of adhesion. ECM-deficient Ehlers-Danlos syndrome (EDS) fibroblasts, to adhere to rare fibronectin (FN) fibrils, and to proliferate, only organize, as FN receptor, the alphavbeta3 integrin. We report that in EDS cells the alphavbeta3 integrin is bound to talin and vinculin, but not to tensin, and that actin cytoskeleton is disorganized. Furthermore, in EDS cells Bcl-2 is down-regulated and caspases are active. We provide evidence that the antibody-mediated alphavbeta3 integrin or the FN inhibition induces anoikis in EDS cells. The alphavbeta3 integrin transduces survival signals to pp60src-mediated tyrosine phosphorylated paxillin, instead than to FAK, and interacts with EGF receptor (EGFR). This complex, when activated by EGF and FN, signals for the rescue of EDS cells from anoikis. Therefore, EDS cells, through the alphavbeta3 integrin-EGFR complexes, engage a paxillin- but not FAK-mediated pathway of cell survival.
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cEDS patients' fibroblasts show disorganization of collagen- and fibronectin-specific α2β1 and α5β1 integrin receptors.
“Our in vitro findings demonstrated that cEDS patients’ fibroblasts show disassembly of many ECM components, including collagen V and III, fibronectin, and fibrillins, and disorganization of collagen- and fibronectin-specific α2β1 and α5β1 integrin receptors [44,45,46,47].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [45]
cEDS cells exhibit reduced in vitro migration capability.
“cEDS cells also exhibit a reduced in vitro migration capability, an abnormal wound healing response, and a crosstalk involving the αvβ3 integrin and epidermal growth factor (EGF) receptor that rescues them from anoikis [44,45,46,47,48,49,50].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [45]
cEDS patients' fibroblasts show disassembly of many ECM components, including collagen V and III, fibronectin, and fibrillins.
“Our in vitro findings demonstrated that cEDS patients’ fibroblasts show disassembly of many ECM components, including collagen V and III, fibronectin, and fibrillins, and disorganization of collagen- and fibronectin-specific α2β1 and α5β1 integrin receptors [44,45,46,47].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [45]
cEDS cells exhibit an abnormal wound healing response.
“cEDS cells also exhibit a reduced in vitro migration capability, an abnormal wound healing response, and a crosstalk involving the αvβ3 integrin and epidermal growth factor (EGF) receptor that rescues them from anoikis [44,45,46,47,48,49,50].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [45]
cEDS cells exhibit a crosstalk involving the αvβ3 integrin and EGF receptor that rescues them from anoikis.
“cEDS cells also exhibit a reduced in vitro migration capability, an abnormal wound healing response, and a crosstalk involving the αvβ3 integrin and epidermal growth factor (EGF) receptor that rescues them from anoikis [44,45,46,47,48,49,50].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [45]
Aberrant expression of collagen V and defective remodeling of ECM in cEDS cells might affect ER homeostasis and autophagy, and consequently activate a pro-survival mechanism mediated by a crosstalk between αvβ3 integrin and EGF receptor.
“In line with these observations, the aberrant expression of collagen V and defective remodeling of ECM in cEDS cells might affect ER homeostasis and autophagy, and consequently activate a pro-survival mechanism mediated by a crosstalk between αvβ3 integrin and EGF receptor [45,50].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [45]
vEDS fibroblasts are in a pre-apoptotic state due to downregulation of the Bcl-2 anti-apoptotic protein and increased levels of caspase enzymes, and activate a cell survival mechanism through an αvβ3-EGFR crosstalk.
“Consistently, we previously demonstrated that vEDS fibroblasts are in a pre-apoptotic state, due to downregulation of the Bcl-2 anti-apoptotic protein and increased levels of caspase enzymes, and activate a cell survival mechanism through an αvβ3-EGFR crosstalk [45,50].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [45]
Expression of αvβ3 integrin is a shared feature of all EDS fibroblast types.
“but express the αvβ3 integrin that is a common trait of all types of EDS fibroblasts [8][9][10][11][12].”
Control fibroblasts do not express αvβ3 integrin under standard growth conditions but organize it preferentially in focal adhesions with hEDS/HSD conditioned medium.
“Furthermore, the evidence that control fibroblasts, which do not express this integrin in standard growth conditions ( [9,10], this work), organize it preferentially in focal adhesions in the presence of hEDS and HSD CM corroborates the involvement of αvβ3 integrin in focal contacts in the transdifferentiation of fibroblasts into myofibroblasts.”
The signal transduction pathway in hEDS and HSD cells differs from that in cEDS and vEDS fibroblasts, where αvβ3 signals to paxillin and p60Src without ILK.
“the signal transduction pathway in hEDS and HSD cells is different from that described in cEDS and vEDS fibroblasts, in which the αvβ3 integrin signals to paxillin and p60Src without involving ILK [10].”
In hEDS and HSD cells, αvβ3 integrin in focal adhesions is phosphorylated at tyrosine 773 and co-distributes with ILK.
“Indeed, we demonstrated that the αvβ3 integrin, localized in focal adhesions of hEDS and HSD cells, is phosphorylated in tyrosine 773 and co-distributes with ILK”
Cultured skin fibroblasts of vEDS patients synthesize aberrant COLLIII that is not organized into the ECM as well as COLLI and fibronectin.
“Cultured skin fibroblasts of vEDS patients synthesize aberrant COLLIII that is not organized into the extracellular matrix (ECM) as well as COLLI and fibronectin (FN) [16,17].”
Our protein data indicated the disorganization of the core proteins of PGs perlecan, versican, and DCN, and their abnormal organization could contribute to the defective COLLIII fibril assembly in vEDS cells, as well as to the defective fibrillogenesis of other COLLs.
“Our protein data indicated the disorganization of the core proteins of PGs perlecan, versican, and DCN, which enhance COLL fibril formation [26], and their abnormal organization could contribute to the defective COLLIII fibril assembly in vEDS cells, as well as to the defective fibrillogenesis of other COLLs previously described in skin fibroblasts of different EDS types and in other connective”
In vEDS patients' skin fibroblasts, abnormal synthesis and deposition of COLLIII into the ECM together with disarray of FN and lack of COLLs- and FN-specific integrin receptors were previously demonstrated.
“In vEDS patients’ skin fibroblasts, we previously demonstrated an abnormal synthesis and deposition of COLLIII into the ECM together with the disarray of FN and the lack of COLLs- and FN-specific integrin receptors [16,17].”
Previous study demonstrated in vEDS fibroblasts a decrease of Bcl-2 protein expression and activation of caspase enzymes.
“our previous study demonstrated in vEDS fibroblasts the decrease of Bcl-2 protein expression and the activation of caspase enzymes”
The rescue from anoikis is driven in vEDS fibroblasts by a survival signaling transduced through the cross-talk between the αvβ3 integrin and EGF receptor.
“The rescue from anoikis is driven in vEDS fibroblasts by a survival signaling transduced through the cross-talk between the αvβ3 integrin and EGF receptor [17]”
vEDS fibroblasts undergo an ECM-deficiency-mediated pre-apoptotic state, in which caspases' activity is up-regulated according to the down-expression of Bcl-2.
“they undergo an ECM-deficiency-mediated pre-apoptotic state, in which caspases’ activity is up-regulated according to the down-expression of Bcl-2 [17]”
Structural mutations in genes encoding for different COLLs, i.e., COLLI, COLLIII, and COLLV, affect not only the assembly but also the secretion pathways of other ECM components in EDS fibroblasts.
“according to the notion that structural mutations in genes encoding for different COLLs, i.e., COLLI, COLLIII, and COLLV, affect not only the assembly but also the secretion pathways of other ECM components in EDS fibroblasts [16,17,33].”
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“A cell survival role for αvβ3 integrin was reported in Ehlers-Danlos syndrome skin fibroblasts, wherein this receptor rescues the cells from apoptosis induced by ECM disassembly due to COL5A1 and COL3A1 mutations (58,59).”
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- Authors
- Zoppi, N., Barlati, S., & Colombi, M.
- Affiliations
- University of Brescia (IT)
- Corresponding author
- Barlati, Sergio
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 1783
- Issue
- 6
- Pages
- 1177-1188
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2035409317
- Cited by
- 31
- References
- 65
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 3
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Funders
- Fondazione Cariplo
- Università degli Studi di Brescia
- Ministero dell'Università e della Ricerca
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- anoikis, integrin αvβ3, EGF receptor, fibronectin, Ehlers-Danlos syndrome, fibroblasts, focal adhesion kinase, paxillin, pp60src, cell survival signaling, apoptosis, actin cytoskeleton, talin, vinculin, caspases, Bcl-2
- MeSH terms
- Actins, Cell Adhesion, Cell Membrane, Cells, Cultured, Cytoskeleton, Ehlers-Danlos Syndrome, Extracellular Matrix, Fibroblasts, Fibronectins, Humans, Phosphorylation, Skin, Tyrosine, Signal Transduction, Vinculin, Talin, Proto-Oncogene Proteins c-bcl-2, Caspases, Anoikis, Integrin alpha5beta1, Integrin alphaVbeta3, Focal Adhesion Kinase 1, Paxillin, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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