Integrins and cell proliferation
Abstract
Cell cycle progression in mammalian cells is strictly regulated by both integrin-mediated adhesion to the extracellular matrix and by binding of growth factors to their receptors. This regulation is mediated by G1 phase cyclin-dependent kinases (CDKs), which are downstream of signaling pathways under the integrated control of both integrins and growth factor receptors. Recent advances demonstrate a surprisingly diverse array of integrin-dependent signals that are channeled into the regulation of the G1 phase CDKs. Regulation of cyclin D1 by the ERK pathway may provide a paradigm for understanding how cell adhesion can determine cell cycle progression.
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Cell cycle progression in eukaryotic cells is strictly regulated by both integrin-mediated adhesion to the ECM and by binding of growth factors to their receptors.
“It is well known that cell cycle progression in eukaryotic cells is strictly regulated by both integrin-mediated adhesion to the ECM and by binding of growth factors to their receptors [68]”
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- Authors
- Schwartz, M. A., & Assoian, R. K.
- Affiliations
- Scripps Research Institute (US)
- University of Pennsylvania (US)
- Corresponding author
- Schwartz, Martin Alexander
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2001-07-15
- Volume
- 114
- Issue
- 14
- Pages
- 2553-2560
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1907686361
- Cited by
- 518
- References
- 92
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 20 · 2021: 16 · 2020: 34 · 2019: 20 · 2018: 17 · 2017: 27 · 2016: 14 · 2015: 24 · 2014: 20 · 2013: 26 · 2012: 20
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- integrins, cell proliferation, cell cycle progression, G1 phase, cyclin-dependent kinases, cyclin D1, ERK signaling, cell adhesion, extracellular matrix, growth factor receptors, signal transduction
- MeSH terms
- Animals, Cell Adhesion, Cell Division, Cytoplasm, Humans, Mammals, Signal Transduction, Integrins, Cyclin-Dependent Kinases
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