Cited by 518Cell Adhesion Molecules ResearchProtein Kinase Regulation and GTPase SignalingCancer-related Molecular Pathways

Integrins and cell proliferation

Schwartz, Martin Alexander, Assoian, Richard K.·2001·Journal of Cell Science

Abstract

Cell cycle progression in mammalian cells is strictly regulated by both integrin-mediated adhesion to the extracellular matrix and by binding of growth factors to their receptors. This regulation is mediated by G1 phase cyclin-dependent kinases (CDKs), which are downstream of signaling pathways under the integrated control of both integrins and growth factor receptors. Recent advances demonstrate a surprisingly diverse array of integrin-dependent signals that are channeled into the regulation of the G1 phase CDKs. Regulation of cyclin D1 by the ERK pathway may provide a paradigm for understanding how cell adhesion can determine cell cycle progression.

Integrity signals

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Crossref · 10.1242/jcs.114.14.2553

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92 of 92 references verified0 citation errors · 0 not checkable

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Authors
Schwartz, M. A., & Assoian, R. K.
Affiliations
  • Scripps Research Institute (US)
  • University of Pennsylvania (US)
Corresponding author
Schwartz, Martin Alexander
Venue
Journal of Cell Science
Published
2001-07-15
Volume
114
Issue
14
Pages
2553-2560
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
OpenAlex
W1907686361
Cited by
518
References
92
Citations by year
2026: 5 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 20 · 2021: 16 · 2020: 34 · 2019: 20 · 2018: 17 · 2017: 27 · 2016: 14 · 2015: 24 · 2014: 20 · 2013: 26 · 2012: 20
FWCI
2.86
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cell Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
integrins, cell proliferation, cell cycle progression, G1 phase, cyclin-dependent kinases, cyclin D1, ERK signaling, cell adhesion, extracellular matrix, growth factor receptors, signal transduction
MeSH terms
Animals, Cell Adhesion, Cell Division, Cytoplasm, Humans, Mammals, Signal Transduction, Integrins, Cyclin-Dependent Kinases

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