The DOI matches its Crossref record; 347 of the 347 references it cites were found in a registry or an index.
Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications
Open accessAbstract
There has been increasing evidence pointing to the mitochondrial respiratory chain (MRC) as a novel and important target for the actions of 17β-estradiol(E2) and estrogen receptors (ER) in a number of cell types and tissues that have high demands for mitochondrial energy metabolism. This novel E2-mediated mitochondrial pathway involves the cooperation of both nuclear and mitochondrial ERα and ERβ and their co-activators on the coordinate regulation of both nuclear DNA- and mitochondrial DNA-encoded genes for MRC proteins. In this paper, we have: 1) comprehensively reviewed studies that reveal a novel role of estrogens and ERs in the regulation of MRC biogenesis; 2) discussed their physiological, pathological and pharmacological implications in the control of cell proliferation and apoptosis in relation to estrogen-mediated carcinogenesis, anticancer drug resistance in human breast cancer cells, neuro-protection for Alzheimer’s disease and Parkinson’s disease in brain, cardiovascular protection in human heart and their beneficial effects in lens physiology related to cataract in the eye; and 3) pointed out new research directions to address the key questions in this important and newly emerging area. We also suggest a novel conceptual approach that will contribute to innovative regimines for the prevention or treatment of a wide variety of medical complications based on E2/ER-mediated MRC biogenesis pathway.
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Cites
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Molecular mechanism of estrogen–estrogen receptor signaling
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Mitochondria: A central target for sex differences in pathologies
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Metadata
- Authors
- Chen, J.-Q., Cammarata, P. R., Baines, C. P., & Yager, J. D.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 1793
- Issue
- 10
- Pages
- 1540-1570
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2100749283
- Cited by
- 264
- References
- 347
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chen, J.-Q., Cammarata, P. R., Baines, C. P., & Yager, J. D. (2009). Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2009.06.001
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