The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Protein selection and export via outer membrane vesicles
Open accessAbstract
Outer membrane vesicles (OMVs) are constitutively produced by all Gram-negative bacteria. OMVs form when buds from the outer membrane (OM) of cells encapsulate periplasmic material and pinch off from the OM to form spheroid particles approximately 10 to 300 nm in diameter. OMVs accomplish a diversity of functional roles yet the OMV’s utility is ultimately determined by its unique composition. Inclusion into OMVs may impart a variety of benefits to the protein cargo, including: protection from proteolytic degradation, enhancement of long-distance delivery, specificity in host-cell targeting, modulation of the immune response, coordinated secretion with other bacterial effectors, and/or exposure to a unique function-promoting environment. Many enriched OMV-associated components are virulence factors, aiding in host cell destruction, immune system evasion, host cell invasion, or antibiotic resistance. Although the mechanistic details of how proteins become enriched as OMV cargo remain elusive, recent data on OM biogenesis and relationships between LPS structure and OMV-cargo inclusion rates shed light on potential models for OM organization and consequent OMV budding. In this review, mechanisms based on pre-existing OM microdomains are proposed to explain how cargo may experience differing levels of enrichment in OMVs and degrees of association with OMVs during extracellular export.
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“P. aeruginosa secretes OMVs to deliver virulence factors and sRNAs into lung epithelial cells through the diffusion the mucus layer.44,47,52–55”
From Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics (2022) · cites this paper as [44]
In the citing paper
“OMVs are bacterial components that can be released spontaneously to the environment during growth by many Gram-negative bacteria.”
From Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics (2022) · cites this paper as [44]
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Cites
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
Silhavy, T. J., Kahne, D., & Walker, S. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000414 · Cited by 3,798
Peptidoglycan structure and architecture
Vollmer, W., Blanot, D., & De Pedro, M. A. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00094.x · Cited by 2,340
Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles
Kulp, A., & Kuehn, M. J. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.091208.073413 · Cited by 1,533
Self-citationStructures of Gram-Negative Cell Walls and Their Derived Membrane Vesicles
Beveridge, T. J. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.16.4725-4733.1999 · Cited by 1,528
Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles
Ellis, T. N., & Kuehn, M. J. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-09 · Cited by 955
Self-citationBacterial outer membrane vesicles and the host–pathogen interaction
Kuehn, M. J., & Kesty, N. C. (2005) · Genes & Development · doi:10.1101/gad.1299905 · Cited by 951
Self-citationRelease of outer membrane vesicles by Gram‐negative bacteria is a novel envelope stress response
McBroom, A. J., & Kuehn, M. J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05522.x · Cited by 734
Self-citationKadurugamuwa, J. L., & Beveridge, T. J. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.14.3998-4008.1995 · Cited by 678
Bomberger, J. M., MacEachran, D. P., Coutermarsh, B. A., Ye, S., O'Toole, G. A., & Stanton, B. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000382 · Cited by 614
Cited by
Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions
Schwechheimer, C., & Kuehn, M. J. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3525 · Cited by 1,922
Self-citationQin, S., Xiao, W., Zhou, C., Pu, Q., Deng, X., Lan, L., Liang, H., Song, X., & Wu, M. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01056-1 · Cited by 1,703
A new pathway for mitochondrial quality control: Mitochondrial-derived vesicles
Sugiura, A., McLelland, G., Fon, E. A., & McBride, H. M. (2014) · The EMBO Journal · doi:10.15252/embj.201488104 · Cited by 862
Bacterial outer membrane vesicles as a platform for biomedical applications: An update
Li, M., Zhou, H., Yang, C., Wu, Y., Zhou, X., Liu, H., & Wang, Y. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.031 · Cited by 370
Functional Advantages of Porphyromonas gingivalis Vesicles
Ho, M.-H., Chen, C.-H., Goodwin, J. S., Wang, B.-Y., & Xie, H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0123448 · Cited by 167
Metadata
- Authors
- Bonnington, K. E., & Kuehn, M. J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 1843
- Issue
- 8
- Pages
- 1612-1619
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2141281036
- Cited by
- 309
- References
- 66
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bonnington, K. E., & Kuehn, M. J. (2014). Protein selection and export via outer membrane vesicles. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2013.12.011
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
