A new pathway for mitochondrial quality control: Mitochondrial-derived vesicles
Open accessAbstract
The last decade has been marked by tremendous progress in our understanding of the cell biology of mitochondria, with the identification of molecules and mechanisms that regulate their fusion, fission, motility, and the architectural transitions within the inner membrane. More importantly, the manipulation of these machineries in tissues has provided links between mitochondrial dynamics and physiology. Indeed, just as the proteins required for fusion and fission were identified, they were quickly linked to both rare and common human diseases. This highlighted the critical importance of this emerging field to medicine, with new hopes of finding drugable targets for numerous pathologies, from neurodegenerative diseases to inflammation and cancer. In the midst of these exciting new discoveries, an unexpected new aspect of mitochondrial cell biology has been uncovered; the generation of small vesicular carriers that transport mitochondrial proteins and lipids to other intracellular organelles. These mitochondrial-derived vesicles (MDVs) were first found to transport a mitochondrial outer membrane protein MAPL to a subpopulation of peroxisomes. However, other MDVs did not target peroxisomes and instead fused with the late endosome, or multivesicular body. The Parkinson's disease-associated proteins Vps35, Parkin, and PINK1 are involved in the biogenesis of a subset of these MDVs, linking this novel trafficking pathway to human disease. In this review, we outline what has been learned about the mechanisms and functional importance of MDV transport and speculate on the greater impact of these pathways in cellular physiology.
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Mitochondrial-derived vesicles (MDVs) are a novel way that eliminates damaged mitochondria alternatively to mitophagy.
“Notably, mitochondrial-derived vesicles (MDVs) have also been identified as a novel way that eliminates damaged mitochondria alternatively of mitophagy (99).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [99]
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From mitochondria to sarcopenia: role of 17β-estradiol and testosterone
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“Notably, mitochondrial-derived vesicles (MDVs) have also been identified as a novel way that eliminates damaged mitochondria alternatively of mitophagy (99).”
BackgroundEtiology of type 2 diabetes and Alzheimer’s disease: Exploring the mitochondria
Silzer, T. K., & Phillips, N. R. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.04.004 · Cited by 53 · see citing works
Lin, T.-K., Lin, K.-J., Lin, K.-L., Liou, C.-W., Chen, S.-D., Chuang, Y.-C., Wang, P.-W., Chuang, J.-H., & Wang, T.-J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.607392 · Cited by 19 · see citing works
- Authors
- Sugiura, A., McLelland, G., Fon, E. A., & McBride, H. M.
- Affiliations
- McGill University (CA)
- Corresponding author
- McBride, Heidi M
- Venue
- The EMBO Journal
- Published
- 2014-08-08
- Volume
- 33
- Issue
- 19
- Pages
- 2142-2156
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC4282503
- OpenAlex
- W2110054105
- Cited by
- 862
- References
- 155
- Citations by year
- 2026: 64 · 2025: 65 · 2024: 104 · 2023: 79 · 2022: 95 · 2021: 95 · 2020: 82 · 2019: 58 · 2018: 62 · 2017: 61 · 2016: 50 · 2015: 41 · 2014: 5
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Heart and Stroke Foundation of Ontario
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- mitochondrial-derived vesicles, mitochondrial quality control, MAPL, peroxisomes, multivesicular bodies, late endosomes, Parkinson's disease, VPS35, Parkin, PINK1, mitochondrial dynamics, mitochondrial fission and fusion
- MeSH terms
- Animals, Humans, Mitochondria, Organelles, Transport Vesicles, Mitochondrial Proteins
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