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Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

Devereaux, Kelly, Dall’Armi, Claudia, Alcazar-Roman, Abel, Ogasawara, Yuta, Zhou, Xiang, Wang, Fan, Yamamoto, Akitsugu, De Camilli, Pietro, Di Paolo, Gilbert·2013·PLoS ONE
DOI 10.1371/journal.pone.0076405PMC PMC3789715
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Crossref · 10.1371/journal.pone.0076405

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  • Approximately 60-70% of the PI(3)P pool is produced by the lipid kinase VPS34.

    “Approximately 60–70% of the PI(3)P pool is produced by the lipid kinase VPS34”

    From PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity (2025) · cites this paper as Devereaux et al., 2013

    The Results section (“Steady-state and starvation-induced PI3P detected in Vps34 KO MEFs”) reports a ~65% decrease in PI3P after Vps34 knockout, supporting the stated range. The authors limit that conclusion to their mouse embryonic fibroblasts; the claim leaves the cell type unspecified and thus implies a more general PI3P pool than the experiment establishes. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • In mouse embryonic fibroblasts, approximately two-thirds of the PI(3)P pool is generated by the lipid kinase VPS34.

    “In mouse embryonic fibroblasts, approximately two-thirds of the PI(3)P pool is generated by the lipid kinase VPS34 (Devereaux et al., 2013; Ikonomov et al., 2015).”

    From Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity (2023) · cites this paper as Devereaux et al., 2013

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Metadata

Authors
Devereaux, K., Dall’Armi, C., Alcazar-Roman, A., Ogasawara, Y., Zhou, X., Wang, F., Yamamoto, A., De Camilli, P., & Di Paolo, G.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-10-03
Volume
8
Issue
10
Pages
e76405
ISSN
1932-6203
DOI
10.1371/journal.pone.0076405
PMC
PMC3789715
Cited by
182
References
11
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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