Cited by 5,621PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

The phosphoinositide 3-kinase pathway

Cantley, Lewis C.·2002·Science

Abstract

Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.

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Crossref · 10.1126/science.296.5573.1655

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  • Activation of phosphoinositide-3-kinase by ligation of growth factors to their cellular receptors promotes recruitment of Akt to the plasma membrane and its subsequent activation.

    “Activation of phosphoinositide-3-kinase (PI3K) by ligation of growth factors to their cellular receptors promotes recruitment of Akt to the plasma membrane and its subsequent activation 28.”

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Authors
Cantley, L. C.
Affiliations
Beth Israel Deaconess Medical Center (US)
Corresponding author
Cantley, Lewis C.
Venue
Science
Published
2002-05-31
Volume
296
Issue
5573
Pages
1655-1657
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2070732456
Cited by
5,621
References
9
Citations by year
2026: 87 · 2025: 137 · 2024: 134 · 2023: 182 · 2022: 200 · 2021: 203 · 2020: 216 · 2019: 215 · 2018: 232 · 2017: 276 · 2016: 243 · 2015: 297 · 2014: 292 · 2013: 306 · 2012: 325
FWCI
76.33
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (R01GM041890)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
phosphatidylinositol 3-kinase, PI3K signaling, phosphatidylinositol 3,4,5-trisphosphate, cell survival signaling, gene expression regulation, cellular metabolism, cytoskeletal rearrangement, diabetes mellitus, cancer, therapeutic target
MeSH terms
Animals, Cell Membrane, Cell Physiological Phenomena, Diabetes Mellitus, Type 2, Humans, Models, Biological, Neoplasms, Phosphorylation, Protein Kinases, Proto-Oncogene Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Phosphatidylinositol Phosphates, Phosphatidylinositol 4,5-Diphosphate, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, 3-Phosphoinositide-Dependent Protein Kinases

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