Epithelial cell–cell junctions and plasma membrane domains
Open accessAbstract
Epithelial cells form a barrier against the environment, but are also required for the regulated exchange of molecules between an organism and its surroundings. Epithelial cells are characterised by a remarkable polarization of their plasma membrane, evidenced by the appearance of structurally, compositionally, and functionally distinct surface domains. Here we consider the (in)dependence of epithelial cell polarisation and the function of smaller plasma membrane domains (e.g. adherens junctions, gap junctions, tight junctions, apical lipid rafts, caveolae, and clathrin-coated pits) in the development and maintenance of cell surface polarity. Recent evidence of cross-talk and/or overlap between the different cell-cell junction components and alternate functions of junction components, including gene expression regulation, are discussed in the context of cell surface polarity.
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Intestinal barrier integrity is chiefly regulated by multicomplex proteins constituted of tight junctions and adherens junctions proteins.
“Accumulating evidence shows that the intestinal barrier integrity is chiefly regulated by several multicomplex proteins, constituted of tight junctions (TJs) and adherens junctions (AJs) proteins [183].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [183]
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BackgroundHarris, T. J. C., & Peifer, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505127 · Cited by 295 · see citing works
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Tsap, M. I., Yatsenko, A. S., Hegermann, J., Beckmann, B., Tsikas, D., & Shcherbata, H. R. (2024) · eLife · doi:10.7554/elife.98020 · Cited by 8 · see citing works
- Authors
- Giepmans, B. N. G., & van IJzendoorn, S. C. D.
- Affiliations
- University Medical Center Groningen (NL)
- ORCID
- Giepmans, Ben N.G.
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 1788
- Issue
- 4
- Pages
- 820-831
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2013094760
- Cited by
- 170
- References
- 2
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 16 · 2018: 17 · 2017: 16 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 12 · 2012: 16
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- plasma membrane domains, adherens junctions, gap junctions, tight junctions, caveolae, clathrin-coated pits, gene expression regulation, epithelial barrier function
- MeSH terms
- Animals, Cell Adhesion, Cell Membrane, Coated Pits, Cell-Membrane, Desmosomes, Epithelial Cells, Humans, Lipid Bilayers, Signal Transduction, Cell Polarity, Gap Junctions, Tight Junctions, Caveolae, Membrane Microdomains, Adherens Junctions
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