The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Polyunsaturated fatty acid–cholesterol interactions: Domain formation in membranes
Open accessAbstract
Polyunsaturated fatty acids (PUFA) constitute an influential group of molecules that promote health by an as yet unknown mechanism. They are structurally distinguished from less unsaturated fatty acids by the presence of a repeating =CH-CH(2)-CH= unit that produces an extremely flexible chain rapidly reorienting through conformational states. The most highly unsaturated case in point is docosahexaenoic acid (DHA) with 6 double bonds. This review will summarize how the high disorder of DHA affects the properties of the membrane phospholipids into which the PUFA incorporates, focusing upon the profound impact on the interaction with cholesterol. Results obtained with model membranes using an array of biophysical techniques will be presented. They demonstrate DHA and the sterol possesses a mutual aversion that drives the lateral segregation of DHA-containing phospholipids into highly disordered domains away from cholesterol. These domains are compositionally and organizationally the opposite of lipid rafts, the ordered domain enriched in predominantly saturated sphingolipids "glued" together by cholesterol that is believed to serve as the platform for signaling proteins. We hypothesize that DHA-rich domains also form in the plasma membrane and are responsible, in part, for the diverse range of health benefits associated with DHA.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In KO astrocytes, the membrane PL profile favored the highly unsaturated PC species and contained less SM, rendering the membrane structurally incompatible with cholesterol44.”
From An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis (2023) · cites this paper as [44]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts
Brown, D. A., & London, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000005200 · Cited by 2,344
Rafts defined: a report on the Keystone symposium on lipid rafts and cell function
PIKE, L. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.e600002-jlr200 · Cited by 1,500
The State of Lipid Rafts: From Model Membranes to Cells
Edidin, M. A. (2003) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.142439 · Cited by 1,357
Biomembranes: molecular structure and function
(1989) · Choice Reviews Online · doi:10.5860/choice.27-0304 · Cited by 1,232
Vist, M., & Davis, J. H. (1990) · Biochemistry · doi:10.1021/bi00454a021 · Cited by 1,121
Structure and Origin of Ordered Lipid Domains in Biological Membranes
Brown, D. A., & London, E. (1998) · The Journal of Membrane Biology · doi:10.1007/s002329900397 · Cited by 976
Docosahexaenoic acid: Membrane properties of a unique fatty acid
Stillwell, W., & Wassall, S. R. (2003) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(03)00101-4 · Cited by 872
Self-citationAhmed, S. N., Brown, D. A., & London, E. (1997) · Biochemistry · doi:10.1021/bi971167g · Cited by 672
Role of cholesterol in lipid raft formation: lessons from lipid model systems
Silvius, J. R. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00016-6 · Cited by 582
Flagged first, then by citations
Research works printed but not linked: 1
- Salem, 1983, Asymmetry of phosphatidylethanolamine molecular species in the human lymphocyte plasma membrane, 24th Intl. Conf. Biochem. Lipids, 44
Cited by
Sorted by citations
Items 101–102 of 102
An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
Talvio, K., Wagner, V. A., Minkeviciene, R., Kirkwood, J. S., Kulinich, A. O., Umemori, J., Bhatia, A., Hur, M., Käkelä, R., Ethell, I. M., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05147-9 · Cited by 8
Astrocytes in fragile X syndrome
Talvio, K., & Castrén, M. L. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1322541 · Cited by 8
Metadata
- Authors
- Wassall, S. R., & Stillwell, W.
- Affiliations
- Indiana University – Purdue University Indianapolis (US)
- Corresponding author
- Wassall, Stephen R.
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 1788
- Issue
- 1
- Pages
- 24-32
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2004029325
- Cited by
- 292
- References
- 96
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 18 · 2023: 8 · 2022: 22 · 2021: 25 · 2020: 14 · 2019: 12 · 2018: 29 · 2017: 16 · 2016: 30 · 2015: 18 · 2014: 14 · 2013: 18 · 2012: 19
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Indiana University-Purdue University Indianapolis
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- polyunsaturated fatty acids, docosahexaenoic acid, cholesterol, lipid rafts, membrane domain formation, lateral segregation, model membranes, plasma membrane, membrane fluidity
- MeSH terms
- Animals, Cholesterol, Docosahexaenoic Acids, Fatty Acids, Unsaturated, Humans, Hydrogen Bonding, Membranes, Models, Biological, Models, Molecular, Oleic Acids, Molecular Structure, Membrane Microdomains
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
