Cited by 292Lipid Membrane Structure and BehaviorFatty Acid Research and HealthLipid metabolism and biosynthesis

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Polyunsaturated fatty acid–cholesterol interactions: Domain formation in membranes

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Wassall, Stephen R., Stillwell, William·2009·Biochimica et Biophysica Acta (BBA) - Biomembranes

DOI 10.1016/j.bbamem.2008.10.011

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Abstract

Polyunsaturated fatty acids (PUFA) constitute an influential group of molecules that promote health by an as yet unknown mechanism. They are structurally distinguished from less unsaturated fatty acids by the presence of a repeating =CH-CH(2)-CH= unit that produces an extremely flexible chain rapidly reorienting through conformational states. The most highly unsaturated case in point is docosahexaenoic acid (DHA) with 6 double bonds. This review will summarize how the high disorder of DHA affects the properties of the membrane phospholipids into which the PUFA incorporates, focusing upon the profound impact on the interaction with cholesterol. Results obtained with model membranes using an array of biophysical techniques will be presented. They demonstrate DHA and the sterol possesses a mutual aversion that drives the lateral segregation of DHA-containing phospholipids into highly disordered domains away from cholesterol. These domains are compositionally and organizationally the opposite of lipid rafts, the ordered domain enriched in predominantly saturated sphingolipids "glued" together by cholesterol that is believed to serve as the platform for signaling proteins. We hypothesize that DHA-rich domains also form in the plasma membrane and are responsible, in part, for the diverse range of health benefits associated with DHA.

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Authors: Wassall, S. R., & Stillwell, W.
Affiliations: Indiana University – Purdue University Indianapolis (US)
Corresponding author: Wassall, Stephen R.
Venue: Biochimica et Biophysica Acta (BBA) - Biomembranes
Publisher: Elsevier BV
Published: 2009-01
Volume: 1788
Issue: 1
Pages: 24-32
ISSN: 0005-2736 (ISSN-L)
DOI: 10.1016/j.bbamem.2008.10.011
OpenAlex: W2004029325
Cited by: 292
References: 96
Citations by year: 2026: 10 · 2025: 10 · 2024: 18 · 2023: 8 · 2022: 22 · 2021: 25 · 2020: 14 · 2019: 12 · 2018: 29 · 2017: 16 · 2016: 30 · 2015: 18 · 2014: 14 · 2013: 18 · 2012: 19
FWCI: 0.75
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1694 d)
Locations: Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
PubMed (publishedVersion)
Funders: Indiana University-Purdue University Indianapolis
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: polyunsaturated fatty acids, docosahexaenoic acid, cholesterol, lipid rafts, membrane domain formation, lateral segregation, model membranes, plasma membrane, membrane fluidity
MeSH terms: Animals, Cholesterol, Docosahexaenoic Acids, Fatty Acids, Unsaturated, Humans, Hydrogen Bonding, Membranes, Models, Biological, Models, Molecular, Oleic Acids, Molecular Structure, Membrane Microdomains

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Polyunsaturated fatty acid–cholesterol interactions: Domain formation in membranes

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