Cited by 248Lipid Membrane Structure and BehaviorMitochondrial Function and PathologyLipid metabolism and biosynthesis

The role of cardiolipin in the structural organization of mitochondrial membranes

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Schlame, Michael, Ren, Mindong·2009·Biochimica et Biophysica Acta (BBA) - Biomembranes

Abstract

Considerable progress has recently been made in understanding the role of cardiolipin in mitochondria. In this brief review, we discuss new data that show how cardiolipin specifically contributes to the lateral organization of mitochondrial membranes. We argue that the function of cardiolipin has to be understood in the context of dynamic membrane assembly rather than static membrane structure, and we propose that remodeling of cardiolipin, i.e. the formation of uniformly substituted molecular species, may reduce the energy barrier of the assembly process.

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Crossref · 10.1016/j.bbamem.2009.04.019

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  • Cardiolipin regulates mitochondrial fusion and fission.

    “Cardiolipin is also involved in the regulation of mitochondrial fusion and fission191–193.”

    From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [193]

    Section 2 discusses cardiolipin’s role in organizing mitochondrial membrane domains and respiratory protein complexes, while Section 5 discusses membrane assembly. Neither addresses regulation of mitochondrial fusion or fission; searches for those processes and mitochondrial dynamics found no relevant passage in our copy. (LLM, conf=0.72)

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Authors
Schlame, M., & Ren, M.
Affiliations
NYU Langone Health (US)
Corresponding author
Schlame, Michael
Venue
Biochimica et Biophysica Acta (BBA) - Biomembranes
Publisher
Elsevier BV
Published
2009-10
Volume
1788
Issue
10
Pages
2080-2083
ISSN
0005-2736 (ISSN-L)
OpenAlex
W2114991593
Cited by
248
References
40
Citations by year
2026: 9 · 2025: 15 · 2024: 7 · 2023: 5 · 2022: 14 · 2021: 12 · 2020: 15 · 2019: 22 · 2018: 16 · 2017: 15 · 2016: 16 · 2015: 18 · 2014: 16 · 2013: 16 · 2012: 27
FWCI
1.33
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Barth Syndrome Foundation
  • United Mitochondrial Disease Foundation
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL078788, R01HL078788)
  • National Institute of General Medical Sciences (R01GM115593)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
cardiolipin, mitochondrial membrane, membrane lateral organization, membrane assembly, cardiolipin remodeling, membrane structure
MeSH terms
Animals, Cardiolipins, Humans, Mitochondria, Mitochondrial Membranes

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