The role of cardiolipin in the structural organization of mitochondrial membranes
Open accessAbstract
Considerable progress has recently been made in understanding the role of cardiolipin in mitochondria. In this brief review, we discuss new data that show how cardiolipin specifically contributes to the lateral organization of mitochondrial membranes. We argue that the function of cardiolipin has to be understood in the context of dynamic membrane assembly rather than static membrane structure, and we propose that remodeling of cardiolipin, i.e. the formation of uniformly substituted molecular species, may reduce the energy barrier of the assembly process.
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Cardiolipin regulates mitochondrial fusion and fission.
“Cardiolipin is also involved in the regulation of mitochondrial fusion and fission191–193.”
From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [193]
Section 2 discusses cardiolipin’s role in organizing mitochondrial membrane domains and respiratory protein complexes, while Section 5 discusses membrane assembly. Neither addresses regulation of mitochondrial fusion or fission; searches for those processes and mitochondrial dynamics found no relevant passage in our copy. (LLM, conf=0.72)
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- Authors
- Schlame, M., & Ren, M.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Schlame, Michael
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 1788
- Issue
- 10
- Pages
- 2080-2083
- ISSN
- 0005-2736 (ISSN-L)
- PMC
- PMC2757492
- OpenAlex
- W2114991593
- Cited by
- 248
- References
- 40
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 7 · 2023: 5 · 2022: 14 · 2021: 12 · 2020: 15 · 2019: 22 · 2018: 16 · 2017: 15 · 2016: 16 · 2015: 18 · 2014: 16 · 2013: 16 · 2012: 27
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Barth Syndrome Foundation
- United Mitochondrial Disease Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL078788, R01HL078788)
- National Institute of General Medical Sciences (R01GM115593)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- cardiolipin, mitochondrial membrane, membrane lateral organization, membrane assembly, cardiolipin remodeling, membrane structure
- MeSH terms
- Animals, Cardiolipins, Humans, Mitochondria, Mitochondrial Membranes
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