The DOI matches its Crossref record; 475 of the 475 references it cites were found in a registry or an index.
Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration
Open accessAbstract
Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory A(1) receptors (A1R) and facilitatory A(2A) receptors (A2AR), mostly controlling excitatory glutamatergic synapses: A1R impose a tonic brake on excitatory transmission, whereas A2AR are selectively engaged to promote synaptic plasticity phenomena. This neuromodulatory role of adenosine is strikingly similar to the role of adenosine in the control of brain disorders; thus, A1R mostly act as a hurdle that needs to be overcame to begin neurodegeneration and, accordingly, A1R only effectively control neurodegeneration if activated in the temporal vicinity of brain insults; in contrast, the blockade of A2AR alleviates the long-term burden of brain disorders in different neurodegenerative conditions such as ischemia, epilepsy, Parkinson's or Alzheimer's disease and also seem to afford benefits in some psychiatric conditions. In spite of this qualitative agreement between neuromodulation and neuroprotection by A1R and A2AR, it is still unclear if the role of A1R and A2AR in the control of neuroprotection is mostly due to the control of glutamatergic transmission, or if it is instead due to the different homeostatic roles of these receptors related with the control of metabolism, of neuron-glia communication, of neuroinflammation, of neurogenesis or of the control of action of growth factors. In spite of this current mechanistic uncertainty, it seems evident that targeting adenosine receptors might indeed constitute a novel strategy to control the demise of different neurological and psychiatric disorders.
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Receptors for Purines and Pyrimidines
Burnstock, G., & Verkhratsky, A. (2012) · Springer eBooks · doi:10.1007/978-3-642-28863-0_5 · Cited by 3,962
Flagged first, then by citations
Research works printed but not linked: 3
- Porciúncula, 2006, Blockade of adenosine A 2A receptors differently alters convulsive behaviour and prevents hippocampal damage in two models of temporal lobe epilepsy, Purinergic Signal, 2, 134
- Fernandez, 2008, .U.-C.I. Group, The safety and efficacy of istradephylline, an adenosine A2A antagonist, as monotherapy in Parkinson's disease: results of the KW-6002-US-051 trial, Mov. Disord., 23, S87
- Kaster, 2010, Genetic or pharmacological blockade of adenosine A2A receptors prevents behavioral and morphological effects of chronic stress in mice, Purinergic Signal, 6, S93
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Shang, L., Huang, Y., Xie, X., Ye, S., & Chen, C. (2022) · Dose-Response · doi:10.1177/15593258221093411
Grković, I., Mitrović, N., Dragić, M., & Kontić, M. Z. (2022) · PubMed · doi:10.14670/hh-18-471
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Ribeiro, D. E., Kaster, M. P., Ulrich, H., Lisboa, S. F. D. S., & Joca, S. R. L. (2023) · Springer eBooks · doi:10.1007/978-3-031-26945-5_7
Self-citationMartins, A. C., Pinheiro, J. D. S., Szinwelski, L., Cidade, E. R., Santin, D. F., Proença, L. D., Araújo, B. A., Pereira, M. L. S., & Jardim, L. B. (2024) · The Cerebellum · doi:10.1007/s12311-024-01717-7
Bossi, S., Daniel, H., & McLean, H. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1406238
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Lezmy, J., Quintela‐López, T., Woermann, N., Mao, S., Thompson, C., & Attwell, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.17.633566
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Pulido, L. M. (2013) · TDX (Tesis Doctorals en Xarxa)
Brockhoff, B. (2015) · NSUWorks (Nova Southeastern University)
Ji, Y., Cui, X., Ding, Z., Wang, X. Y., Wang, Y., Zhang, Y., Yuan, Z., Chang, Z., Liu, K., & Liu, Y. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251407109
Tait, S., Fratini, F., Boussadia, Z., Gaddini, L., Marra, M., Pera, L. L., Venturini, G., & Ferrante, A. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111708
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Taha, M. M. E., Abdelwahab, S. İ., Sahli, K. A., Jeraiby, M., Qadri, M. M., Alarifi, A., Farasani, A., & Moshi, J. M. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261450996
Hou, Z., Zhang, X., Yang, G., Shen, B., Dong, W., Jing, D., Hong, S., & Li, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27115072
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Metadata
- Authors
- Gomes, C. V., Kaster, M. P., Tomé, A. R., Agostinho, P. M., & Cunha, R. A.
- Affiliations
- University of Coimbra (PT)
- Corresponding author
- Cunha, Rodrigo A.
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 1808
- Issue
- 5
- Pages
- 1380-1399
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2081196843
- Cited by
- 419
- References
- 473
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 15 · 2023: 21 · 2022: 30 · 2021: 24 · 2020: 37 · 2019: 43 · 2018: 36 · 2017: 30 · 2016: 27 · 2015: 38 · 2014: 32 · 2013: 22 · 2012: 26
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- adenosine receptors, adenosine A1 receptor, adenosine A2A receptor, neuroprotection, neurodegeneration, neuromodulation, glutamatergic synapses, synaptic plasticity, ischemia, epilepsy, Parkinson's disease, Alzheimer's disease, neuroinflammation, neuron-glia communication, neurogenesis, growth factors, mental illness, adenosine receptor agonists
- MeSH terms
- Animals, Brain Diseases, Humans, Nerve Degeneration, Receptors, Purinergic P1, Neurotransmitter Agents, Neuroprotective Agents
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