The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Outer membrane permeability and antibiotic resistance
Open accessAbstract
Summary To date most antibiotics are targeted at intracellular processes, and must be able to penetrate the bacterial cell envelope. In particular, the outer membrane of Gram-negative bacteria provides a formidable barrier that must be overcome. There are essentially two pathways that antibiotics can take through the outer membrane: a lipid-mediated pathway for hydrophobic antibiotics, and general diffusion porins for hydrophilic antibiotics. The lipid and protein compositions of the outer membrane have a strong impact on the sensitivity of bacteria to many types of antibiotics, and drug resistance involving modifications of these macromolecules is common. This review will describe the molecular mechanisms for permeation of antibiotics through the outer membrane, and the strategies that bacteria have deployed to resist antibiotics by modifications of these pathways.
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Cites
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
Agents that increase the permeability of the outer membrane
Vaara, M. (1992) · Microbiological Reviews · doi:10.1128/mr.56.3.395-411.1992 · Cited by 1,879
Cited by
Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It
Zgurskaya, H. I., López, C. A., & Gnanakaran, S. (2015) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5b00097 · Cited by 580
Zhang, Y., Gu, A. Z., Cen, T., Li, X., He, M., Li, D., & Chen, J. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.01.032 · Cited by 472
Essential Oils, A New Horizon in Combating Bacterial Antibiotic Resistance
Yap, P. S. X., Yiap, B. C., Ping, H. C., & Lim, S. H. E. (2014) · The Open Microbiology Journal · doi:10.2174/1874285801408010006 · Cited by 426
Physical properties of the bacterial outer membrane
Sun, J., Rutherford, S. T., Silhavy, T. J., & Huang, K. C. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00638-0 · Cited by 404
The Microbiologist’s Guide to Membrane Potential Dynamics
Benarroch, J. M., & Asally, M. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2019.12.008 · Cited by 333
Metadata
- Authors
- Delcour, A. H.
- Venue
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 1794
- Issue
- 5
- Pages
- 808-816
- ISSN
- 1570-9639 (ISSN-L)
- OpenAlex
- W1981267913
- Cited by
- 1,762
- References
- 2
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- green
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