The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.
Proteases involved in cartilage matrix degradation in osteoarthritis
Open accessAbstract
Osteoarthritis is a common joint disease for which there are currently no disease-modifying drugs available. Degradation of the cartilage extracellular matrix is a central feature of the disease and is widely though to be mediated by proteinases that degrade structural components of the matrix, primarily aggrecan and collagen. Studies on transgenic mice have confirmed the central role of Adamalysin with Thrombospondin Motifs 5 (ADAMTS-5) in aggrecan degradation, and the collagenolytic matrix metalloproteinase MMP-13 in collagen degradation. This review discusses recent advances in current understanding of the mechanisms regulating expression of these key enzymes, as well as reviewing the roles of other proteinases in cartilage destruction.
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Cites
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Cited by
The Different Roles of Aggrecan Interaction Domains
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Metadata
- Authors
- Troeberg, L., & Nagase, H.
- Venue
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 1824
- Issue
- 1
- Pages
- 133-145
- ISSN
- 1570-9639 (ISSN-L)
- OpenAlex
- W2010404343
- Cited by
- 579
- References
- 211
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Troeberg, L., & Nagase, H. (2012). Proteases involved in cartilage matrix degradation in osteoarthritis. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. https://doi.org/10.1016/j.bbapap.2011.06.020
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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