Calcium mobilizing second messengers derived from NAD

Guse, Andreas H.

doi:10.1016/j.bbapap.2014.12.015

Cited by 83Calcium signaling and nucleotide metabolismSirtuins and Resveratrol in MedicineAdenosine and Purinergic Signaling

Calcium mobilizing second messengers derived from NAD

Guse, Andreas H.·2015·Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

DOI 10.1016/j.bbapap.2014.12.015

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Abstract

Nicotinamide adenine dinucleotide (NAD) has been known since a long period of time as co-factor of oxidoreductases. However, in the past couple of decades further roles have been assigned to NAD. Here, metabolism of NAD to the Ca²⁺ mobilizing second messengers cyclic adenosine diphosphoribose, nicotinic acid adenine dinucleotide phosphate and adenosine diphosphoribose is reviewed. Moreover, the mechanisms of Ca²⁺ mobilization by these adenine nucleotides and their putative target Ca²⁺ channels, ryanodine receptors and transient receptor potential channels are discussed. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications.

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NAD(P) is a precursor of NAADP, cADPR, and ADPR, which are key regulators of Ca2+ signaling synthesized by CD38 and CD157 using NAD+.
“NAD(P) is a precursor of nicotinic acid adenine dinucleotide phosphate (NAADP), cADPR, and ADPR, which are key regulators of Ca2+ signaling and are synthesized by CD38 and CD157 by the use of NAD+ (Figure 1) (Guse, 2015).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Guse, 2015

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Authors: Guse, A. H.
Affiliations: University Medical Center Hamburg-Eppendorf (DE)
Corresponding author: Guse, Andreas H.
ORCID: Guse, Andreas H.
Venue: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Publisher: Elsevier BV
Published: 2015-09
Volume: 1854
Issue: 9
Pages: 1132-1137
ISSN: 1570-9639 (ISSN-L)
DOI: 10.1016/j.bbapap.2014.12.015
OpenAlex: W2057237823
Cited by: 82
References: 72
Citations by year: 2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 10 · 2021: 10 · 2020: 14 · 2019: 8 · 2018: 9 · 2017: 4 · 2016: 7 · 2015: 7
FWCI: 0.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (GU 360/15-1, 18-1)
Gemeinnützige Hertie-Stiftung (P1140086)
Research Initiative of the City of Hamburg
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Keywords: NAD+, cyclic ADP-ribose, NADPH, ADP-ribose, calcium mobilization, second messengers, ryanodine receptor, TRP channels, NAD+ metabolism
MeSH terms: Adenosine Diphosphate Ribose, Animals, Calcium, Humans, NAD, NADP, Second Messenger Systems, Cyclic ADP-Ribose

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Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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Calcium mobilizing second messengers derived from NAD

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Integrity signals

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