Aerobic and resistance exercise training reverses age‐dependent decline in NAD+salvage capacity in human skeletal muscle
Open accessAbstract
Aging decreases skeletal muscle mass and strength, but aerobic and resistance exercise training maintains skeletal muscle function. NAD+ is a coenzyme for ATP production and a required substrate for enzymes regulating cellular homeostasis. In skeletal muscle, NAD+ is mainly generated by the NAD+ salvage pathway in which nicotinamide phosphoribosyltransferase (NAMPT) is rate-limiting. NAMPT decreases with age in human skeletal muscle, and aerobic exercise training increases NAMPT levels in young men. However, whether distinct modes of exercise training increase NAMPT levels in both young and old people is unknown. We assessed the effects of 12 weeks of aerobic and resistance exercise training on skeletal muscle abundance of NAMPT, nicotinamide riboside kinase 2 (NRK2), and nicotinamide mononucleotide adenylyltransferase (NMNAT) 1 and 3 in young (≤35 years) and older (≥55 years) individuals. NAMPT in skeletal muscle correlated negatively with age (r2 = 0.297, P < 0.001, n = 57), and VO2peak was the best predictor of NAMPT levels. Moreover, aerobic exercise training increased NAMPT abundance 12% and 28% in young and older individuals, respectively, whereas resistance exercise training increased NAMPT abundance 25% and 30% in young and in older individuals, respectively. None of the other proteins changed with exercise training. In a separate cohort of young and old people, levels of NAMPT, NRK1, and NMNAT1/2 in abdominal subcutaneous adipose tissue were not affected by either age or 6 weeks of high-intensity interval training. Collectively, exercise training reverses the age-dependent decline in skeletal muscle NAMPT abundance, and our findings highlight the value of exercise training in ameliorating age-associated deterioration of skeletal muscle function.
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Aerobic exercise training can increase muscle NAMPT activity and NAD+.
“aerobic exercise training can increase muscle NAMPT activity and NAD+ [170, 172, 173].”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [173]
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Self-citationHealthy aging and muscle function are positively associated with NAD+ abundance in humans
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Targeting Intramyocellular Lipids to Improve Aging Muscle Function
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- Authors
- de Guia, R. M., Agerholm, M., Nielsen, T. S., Consitt, L. A., Søgaard, D., Helge, J. W., Larsen, S., Brandauer, J., Houmard, J. A., & Treebak, J. T.
- Affiliations
- Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark
- University of Copenhagen (DK)
- Ohio University (US)
- Gettysburg College (US)
- East Carolina University (US)
- Corresponding author
- Treebak, Jonas T.
- ORCID
- Venue
- Physiological Reports
- Publisher
- Wiley
- Published
- 2019-06
- Volume
- 7
- Issue
- 12
- Pages
- e14139-e14139
- ISSN
- 2051-817X (ISSN-L)
- PMC
- PMC6577427
- OpenAlex
- W2950596378
- Cited by
- 99
- References
- 83
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 13 · 2023: 16 · 2022: 16 · 2021: 11 · 2020: 15 · 2019: 2
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Physiological Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- The Scholarship East Carolina University's Institutional Repository (East Carolina University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (AG‐025205, DK‐56112)
- Det Frie Forskningsråd (DFF 4004‐00235, DFF 6110‐00132)
- Novo Nordisk Fonden (NNF14OC0009315)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- NAD+ salvage pathway, visfatin, aerobic exercise training, resistance training, aging, skeletal muscle, nicotinamide mononucleotide adenylyltransferase, high-intensity interval training, peak oxygen uptake, subcutaneous adipose tissue, age-related muscle loss
- MeSH terms
- Adipose Tissue, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Anthropometry, Blood Glucose, Exercise Therapy, Female, Humans, Insulin, Male, Middle Aged, NAD, Nicotinamide-Nucleotide Adenylyltransferase, Cytokines, Phosphotransferases (Alcohol Group Acceptor), Muscle, Skeletal, Intracellular Signaling Peptides and Proteins, Nicotinamide Phosphoribosyltransferase, Resistance Training, Young Adult
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