Monocytic elastase-mediated apolipoprotein-E degradation: Potential involvement of microglial elastase-like proteases in apolipoprotein-E proteolysis in brains with Alzheimers disease

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

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ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

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ApoE Promotes the Proteolytic Degradation of Aβ

Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.010 · Cited by 876 · see citing works

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

Verghese, P. B., Castellano, J. M., Garai, K., Wang, Y., Jiang, H., Shah, A., Bu, G., Frieden, C., & Holtzman, D. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220484110 · Cited by 556 · see citing works

Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

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Clearance of Alzheimer's Aβ Peptide

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Alzheimer's β‐amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

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An immortalized cell line expresses properties of activated microglial cells

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Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice

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Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

Harris, F. M., Brecht, W. J., Xu, Q., Tesseur, I., Kekonius, L., Wyss-Coray, T., Fish, J. D., Masliah, E., Hopkins, P. C., Scearce-Levie, K., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1434398100 · Cited by 342 · see citing works

Cerebrovascular Effects of Apolipoprotein E: Implications for Alzheimer Disease

Zlokovic, B. V. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.2152 · Cited by 263 · see citing works

Intracellular Mechanisms of Amyloid Accumulation and Pathogenesis in Alzheimer's Disease

Glabe, C. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:137 · Cited by 222 · see citing works

Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis

Kim, J., Jiang, H., Park, S., Eltorai, A. E. M., Stewart, F. R., Yoon, H., Basak, J. M., Finn, M. B., & Holtzman, D. M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3773-11.2011 · Cited by 199 · see citing works

Effector mechanisms of cytolytically activated macrophages. I. Secretion of neutral proteases and effect of protease inhibitors.

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Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels

Lee, C. Y. D., Tse, W., Smith, J. D., & Landreth, G. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.295451 · Cited by 178 · see citing works

Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent Aβ Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice

Bien-Ly, N., Gillespie, A. K., Walker, D., Yoon, S. Y., & Huang, Y. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0033-12.2012 · Cited by 170 · see citing works

Identification of Elastase as a Secretory Protease from Cultured Rat Microglia

Nakajima, K., Shimojo, M., Hamanoue, M., Ishiura, S., Sugita, H., & Kohsaka, S. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb11356.x · Cited by 139 · see citing works

Microglia and Alzheimer’s disease

Kalaria, R. N. (1999) · Current Opinion in Hematology · doi:10.1097/00062752-199901000-00004 · Cited by 132 · see citing works

Apolipoprotein E and Low Density Lipoprotein Receptor-related Protein Facilitate Intraneuronal Aβ42 Accumulation in Amyloid Model Mice

Zerbinatti, C. V., Wahrle, S. E., Kim, H., Cam, J. A., Bales, K., Paul, S. M., Holtzman, D. M., & Bu, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604436200 · Cited by 129 · see citing works

Human Coagulation Factor V Is Activated to the Functional Cofactor by Elastase and Cathepsin G Expressed at the Monocyte Surface

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Cathepsin D-mediated proteolysis of apolipoprotein E: Possible role in Alzheimer’s disease

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Novel Cathepsin D Inhibitors Block the Formation of Hyperphosphorylated Tau Fragments in Hippocampus

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Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology

Liu, S., Breitbart, A., Sun, Y., Mehta, P. D., Boutajangout, A., Scholtzova, H., & Wisniewski, T. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12484 · Cited by 60 · see citing works

Microglial Cathepsin B: An Immunological Examination of Cellular and Secreted Species

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The Liver X Receptor Agonist GW3965 Improves Recovery from Mild Repetitive Traumatic Brain Injury in Mice Partly through Apolipoprotein E

Namjoshi, D., Martin, G., Donkin, J. J., Wilkinson, A., Stukas, S. K., Fan, J., Carr, M., Tabarestani, S., Wuerth, K. C., Hancock, R. E. W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053529 · Cited by 51 · see citing works

Proteolytic Degradation of Alzheimer's Disease Amyloid β‐Peptide by a Metalloproteinase from Microglia Cells

Mentlein, R., Ludwig, R., & Martensen, I. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020721.x · Cited by 45 · see citing works

Binding of Apolipoprotein E Inhibits the Oligomer Growth of Amyloid-β Peptide in Solution as Determined by Fluorescence Cross-correlation Spectroscopy

Ly, S., Altman, R., Petrlová, J., Lin, Y., Hilt, S., Huser, T. R., Laurence, T. A., & Voss, J. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.411900 · Cited by 44 · see citing works

Microglia‐Derived Elastase Produces a Low‐Molecular‐Weight Plasminogen that Enhances Neurite Outgrowth in Rat Neocortical Explant Cultures

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The endosomal trafficking of apolipoprotein E3 and E4 in cultured human brain neurons and astrocytes.

Dekroon, R., & Armati, P. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0362 · Cited by 39 · see citing works

A serine peptidase responsible for the inactivation of endogenous cholecystokinin in brain.

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Extracellular Proteolysis of Apolipoprotein E (apoE) by Secreted Serine Neuronal Protease

Tamboli, I. Y., Heo, D., & Rebeck, G. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093120 · Cited by 35 · see citing works

Progress Toward Identification of Protease Activity Involved in Proteolysis of Apolipoprotein E in Human Brain

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Selective binding of soluble Abeta1-40 and Abeta1-42 to a subset of senile plaques.

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Cortical cathepsin D activity and immunolocalization in Alzheimer disease, critical coronary artery disease, and aging

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Metabolism of neuropeptide Y and calcitonin gene-related peptide by cultivated neurons and glial cells

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The Pathological Cross Talk Between Apolipoprotein E and Amyloid-β Peptide in Alzheimer's Disease: Emerging Gene-Based Therapeutic Approaches

Iurescia, S., Fioretti, D. P., Mangialasche, F., & Rinaldi, M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100009 · Cited by 17 · see citing works

Inhibitors of Chymotrypsin-like Proteases Inhibit Eosinophil Peroxidase Release from Activated Human Eosinophils

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Microglia: Housekeeper of the Central Nervous System

Kabba, J. A., Xu, Y., Christian, H., Ruan, W., Kitchen, C., Xiang, Y., Zhang, L., Saavedra, J. M., & Pang, T. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0504-2 · Cited by 251 · see citing works

Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease

Liao, F., Yoon, H., & Kim, J. (2017) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000383 · Cited by 191 · see citing works

Bioinformatic analysis of the SPs and NFTs proteomes unravel putative biomarker candidates for Alzheimer's disease

Ferreira, M., Martins, T. S., Alves, S. R., Rosa, I. M., Vogelgsang, J. S., Hansen, N., Wiltfang, J., Silva, O. A. B. D. C. E., Vitorino, R. M. P., & Henriques, A. G. (2023) · PROTEOMICS · doi:10.1002/pmic.202200515 · Cited by 7 · see citing works

Publications from Juntendo University Graduate School of Medicine, 2015 [1/6]

(2017) · Juntendō Igaku/Juntendo igaku · doi:10.14789/jmj.63.204

Monocytic elastase-mediated apolipoprotein-E degradation: Potential involvement of microglial elastase-like proteases in apolipoprotein-E proteolysis in brains with Alzheimers disease Proteins and proteomics

Suenaga, M., Furuta, A., Wakabayashi, K., Saibara, T., & Matsunaga, Y. (2015) · Biochimica et Biophysica Acta

Proteolytic Degradation of Alzheimer's Disease Amyloid β‐Peptide by a Metalloproteinase from Microglia Cells

Mentlein, R., Ludwig, R., & Martensen, I. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020721.x · Cited by 45 · see citing works

P1‐298: Characterization of novel apoE isoform‐dependent C‐terminal specific proteolysis of Aβ1‐42 by microglia

Liu, F., Lin, S., Chai, X., Demattos, R. B., Paul, S. M., & Lilly, E. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.05.850

ApoE Promotes the Proteolytic Degradation of Aβ

Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.010 · Cited by 876 · see citing works

Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells

Qiu, W. Q., Ye, Z., Kholodenko, D., Seubert, P. A., & Selkoe, D. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6641 · Cited by 175 · see citing works