Cited by 222Stress Responses and CortisolCancer, Stress, Anesthesia, and Immune ResponseNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Stressor-specific alterations in corticosterone and immune responses in mice

Open access

Bowers, Stephanie L., Bilbo, Staci D., Dhabhar, Firdaus S., Nelson, Randy J.·2008·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2007.07.012PMC PMC2175078

Open this paper in CoChat — free account

Abstract

Different stressors likely elicit different physiological and behavioral responses. Previously reported differences in the effects of stressors on immune function may reflect qualitatively different physiological responses to stressors; alternatively, both large and subtle differences in testing protocols and methods among laboratories may make direct comparisons among studies difficult. Here we examine the effects of chronic stressors on plasma corticosterone concentrations, leukocyte redistribution, and skin delayed-type hypersensitivity (DTH), and the effects of acute stressors on plasma corticosterone and leukocyte redistribution. The effects of several commonly used laboratory stressors including restraint, forced swim, isolation, and low ambient temperatures (4 degrees C) were examined. Exposure to each stressor elevated corticosterone concentrations, with restraint (a putative psychological stressor) evoking a significantly higher glucocorticoid response than other stressors. Chronic restraint and forced swim enhanced the DTH response compared to the handled, low temperature, or isolation conditions. Restraint, low temperature, and isolation significantly increased trafficking of lymphocytes and monocytes compared to forced swim or handling. Generally, acute restraint, low temperature, isolation, and handling increased trafficking of lymphocytes and monocytes. Considered together, our results suggest that the different stressors commonly used in psychoneuroimmunology research may not activate the physiological stress response to the same extent. The variation observed in the measured immune responses may reflect differential glucocorticoid activation, differential metabolic adjustments, or both processes in response to specific stressors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbi.2007.07.012

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092
Immunobiology: the immune system in health and disease
(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,111
The concept of allostasis in biology and biomedicine
McEwen, B. S., & Wingfield, J. C. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00024-7 · Cited by 3,302 · cited 1×
“N IH -PA Author M anuscript N IH -PA Author M anuscript physiological mechanisms are engaged to restore homeostasis by a process termed “allostasis” (Dhabhar et al., 2000; McEwen, 1998; McEwen and Wingfield, 2003; Schulkin et al., 1994).”
Stress and the General Adaptation Syndrome
Selye, H. (1950) · BMJ · doi:10.1136/bmj.1.4667.1383 · Cited by 1,481
Acute Stress Enhances while Chronic Stress Suppresses Cell-Mediated Immunityin Vivo:A Potential Role for Leukocyte Trafficking
Dhabhar, F. S., & McEwen, B. S. (1997) · Brain Behavior and Immunity · doi:10.1006/brbi.1997.0508 · Cited by 1,014
Self-citation
Stressor specificity of central neuroendocrine responses: implications for stress-related disorders
Pacák, K., & Palkovits, M. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0436 · Cited by 926
Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms.
Dhabhar, F. S., Miller, A. H., McEwen, B. S., & Spencer, R. L. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.5511 · Cited by 730
Self-citation
Untitled work
(2004) · PubMed · Cited by 681
Animal models of anxiety and depression: how are females different?
Palanza, P. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00010-0 · Cited by 559
Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups
Dayas, C. V., Buller, K. M., Crane, J. W., Xu, Y., & Day, T. A. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01733.x · Cited by 514

Flagged first, then by citations

Show all 55 references

Sorted by citations

Items 101–200 of 222

Real-Time Personalized Physiologically Based Stress Detection for Hazardous Operations
Finseth, T., Dorneich, M. C., Vardeman, S. B., Keren, N., & Franke, W. D. (2023) · IEEE Access · doi:10.1109/access.2023.3254134 · Cited by 25
Limbic system activation is affected by prenatal predator exposure and postnatal environmental enrichment and further moderated by dam and sex
Korgan, A. C., Green, A. D., Perrot, T. S., & Esser, M. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.037 · Cited by 22
A short‐term extremely low frequency electromagnetic field exposure increases circulating leukocyte numbers and affects HPA‐axis signaling in mice
de Kleijn, S., Ferwerda, G., Wiese, M. K., Trentelman, J. J. A., Cuppen, J. J. M., Kozicz, T., de Jager, L., Hermans, P. W. M., & Kemenade, B. M. L. V.-V. (2016) · Bioelectromagnetics · doi:10.1002/bem.21998 · Cited by 20
β-Ionone Attenuates Dexamethasone-Induced Suppression of Collagen and Hyaluronic Acid Synthesis in Human Dermal Fibroblasts
Choi, D., Kang, W., Park, S., Son, B., & Park, T. (2021) · Biomolecules · doi:10.3390/biom11050619 · Cited by 19
Understanding the Trauma of Menstrual Irregularity After COVID Vaccination: A Bird’s-Eye View of Female Immunology
Minakshi, R., Rahman, S., Ayaggari, A., Dutta, D., & Shankar, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.906091 · Cited by 18
Sodium Intake and Disease: Another Relationship to Consider
Baumer-Harrison, C., Breza, J. M., Sumners, C., Krause, E. G., & de Kloet, A. D. (2023) · Nutrients · doi:10.3390/nu15030535 · Cited by 18
Body surface temperature of rats reveals both magnitude and sex differences in the acute stress response
Wongsaengchan, C., McCafferty, D. J., Evans, N. P., McKeegan, D. E. F., & Nager, R. G. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114138 · Cited by 18
Stress and skin leukocyte trafficking as a dual-stage process
Neeman, E., Shaashua, L., Benish, M., Page, G. G., Zmora, O., & Ben‐Eliyahu, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.007 · Cited by 17
Pharmacological manipulation of glucocorticoid receptors differentially affects cocaine self-administration in environmentally enriched and isolated rats
Hofford, R. S., Prendergast, M., & Bardo, M. T. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.01.049 · Cited by 17
Comparison of corticosterone responses to acute stressors: Chronic jugular vein versus trunk blood samples in mice
Nyuyki, K. D., Maloumby, R., Reber, S. O., & Neumann, I. D. (2012) · Stress · doi:10.3109/10253890.2012.655348 · Cited by 17
Studying brain-regulation of immunity with optogenetics and chemogenetics; A new experimental platform
Ben-Shaanan, T. L., Schiller, M., & Rolls, A. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.024 · Cited by 16
Discrete role for maternal stress and gut microbes in shaping maternal and offspring immunity
Chen, H. J., Bischoff, A., Galley, J. D., Peck, L., Bailey, M. T., & Gur, T. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100480 · Cited by 16
High cortisol responders to stress show increased sedation to alcohol compared to low cortisol responders: An alcohol dose–response study
Brkic, S., Söderpalm, B., & Gordh, A. S. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.02.004 · Cited by 16
Differences in Stress-Induced Modulation of the Auditory System Between Wistar and Lewis Rats
Szczepek, A. J., Dietz, G. P. H., Reich, U., Hegend, O., Olze, H., & Mazurek, B. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00828 · Cited by 16
Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens
Sato, D., Hamada, Y., Narita, M., Mori, T., Tezuka, H., Suda, Y., Tanaka, K., Yoshida, S., Tamura, H., Yamanaka, A., et al. (2022) · Molecular Brain · doi:10.1186/s13041-022-00902-1 · Cited by 15
Modified single prolonged stress reduces cocaine self-administration during acquisition regardless of rearing environment
Hofford, R. S., Prendergast, M., & Bardo, M. T. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.10.023 · Cited by 15
Effect of chronic mild stress on serotonergic markers in the skin and brain of the NC/Nga atopic-like mouse strain
Rasul, A., El‐Nour, H., Blakely, R., Lonne‐Rahm, S., Forsberg, J., Johansson, B. A., Theodorsson, E., & Nordlind, K. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-011-1138-8 · Cited by 13
Chronic stress impairs learning and hippocampal cell proliferation in senescence-accelerated prone mice
Yan, W., Zhang, T., Jia, W., Sun, X., & Liu, X. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.12.032 · Cited by 14
Sex differences in the effect of acute fasting on excitatory and inhibitory synapses onto ventral tegmental area dopamine neurons
Godfrey, N., & Borgland, S. L. (2020) · The Journal of Physiology · doi:10.1113/jp280412 · Cited by 14
Transportation stress alters the expression of immunoregulatory cytokines in the porcine thymus
Lv, Q., Zhang, S., & Zhao, R. (2010) · The Veterinary Journal · doi:10.1016/j.tvjl.2009.12.004 · Cited by 13
Preventive effects of metallothionein against DNA and lipid metabolic damages in dyslipidemic mice under repeated mild stress
Higashimoto, M., Isoyama, N., Ishibashi, S., Ogawa, N., Takiguchi, M., Suzuki, S., Ohnishi, Y., & Sato, M. (2013) · The Journal of Medical Investigation · doi:10.2152/jmi.60.240 · Cited by 13
Obesity amplifies influenza virus-driven disease severity in male and female mice
Alarcon, P. C., Damen, M. S. M. A., Ulanowicz, C. J., Sawada, K., Oates, J. R., Tóth, A., Wayland, J. L., Chung, H., Stankiewicz, T. E., Moreno‐Fernandez, M. E., et al. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.09.004 · Cited by 12
Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine, a Prolyl Endopeptidase Inhibitor, Modulates Depression-Like Behavior of Rats in Forced Swimming Test and Activities of Proline-Specific Peptidases in the Brain Structures
Krupina, N. A., Bogdanova, N. G., Khlebnikova, N. N., Золотов, Н. Н., & Крыжановский, Г. Н. (2013) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-013-2010-y · Cited by 12
Age differences in the impact of forced swimming test on serotonin transporter levels in lateral septum and dorsal raphe
Ulloa, R. E., Díaz-Valderrama, A., Herrera‐Perez, J. J., León‐Olea, M., & Martı́nez-Mota, L. (2014) · Behavioral and Brain Functions · doi:10.1186/1744-9081-10-3 · Cited by 12
Repeated Restraint Stress Enhances Hepatic TFR2 Expression and Induces Hepatic Iron Accumulation in Rats
Guo, S., Yang, C., Jiang, S., Ni, Y., Zhao, R., & Ma, W. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01956-4 · Cited by 11
Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice
Noah, T. K., Lee, J., Brown, C. A., Yamani, A. N., Tomar, S., Ganesan, V., Newberry, R. D., Huffnagle, G. B., Divanovic, S., & Hogan, S. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.636198 · Cited by 11
Mice Born to Mothers with Gravida Traumatic Brain Injury Have Distorted Brain Circuitry and Altered Immune Responses
Saber, M., Ortiz, J. B., Rojas-Valencia, L. M., Ma, X., Tallent, B. R., Adelson, P. D., Rowe, R. K., Qiu, S., & Lifshitz, J. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2021.0048 · Cited by 11
Plasma steroids and immune measures vary with restraint duration in a toad (Rhinella icterica)
Titon, S. C. M., Titon, B., de Figueiredo, A. C., Floreste, F. R., Lima, A. S., Cyrino, J. C., & Gomes, F. R. (2022) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2022.113987 · Cited by 11
Effects of hydrolyzed Chlorella vulgaris by malted barley on the immunomodulatory response in ICR mice and in Molt‐4 cells
Kim, N., Kim, K.-Y., Jeong, H., Kim, H., Hong, S., & Um, J. (2010) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3989 · Cited by 11
Enhanced cutaneous hypersensitivity reactions are associated with ovine high and low cortisol responsiveness to acute endotoxin challenge
You, Q., Karrow, N. A., Quinton, M., Mallard, B. A., & Boermans, H. J. (2008) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2008.00664.x · Cited by 11
Role of the Hypothalamo-Pituitary-Adrenal Axis in the Modulation of Pollinosis Induced by Pollen Antigens
Hashimoto, M., Sato, E. F., Hiramoto, K., Kasahara, E., & Inoue, M. (2010) · Allergology International · doi:10.2332/allergolint.09-oa-0133 · Cited by 11
Acute restraint stress increases the frequency of vinblastine-induced micronuclei in mouse bone marrow cells
Malvandi, A. M., Haddad, F., & Moghimi, A. (2010) · Stress · doi:10.3109/10253890903296710 · Cited by 11
Effects of handling on the behavioural phenotype of the neuregulin 1 type III transgenic mouse model for schizophrenia
Guerra, S., Chesworth, R., Weickert, C. S., & Karl, T. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113166 · Cited by 11
Does Stress Elicit Depression? Evidence From Clinical and Preclinical Studies
Sickmann, H. M., Li, Y., Mørk, A., Sánchez, C., & Gulinello, M. E. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_292 · Cited by 10
Role of main neuroendocrine pathways activated by swim stress on mast cell-dependent peritoneal TNF production after LPS administration in mice
Romero-Carbente, J. C., Guzmán‐Mejía, F., Cruz, S. L., López‐Rubalcava, C., & González‐Espinosa, C. (2014) · Inflammation Research · doi:10.1007/s00011-014-0748-y · Cited by 10
Concomitant stress potentiates the preference for, and consumption of, ethanol induced by chronic pre-exposure to ethanol
Morais‐Silva, G., Fernandes‐Santos, J., Moreira‐Silva, D., & Marin, M. T. (2016) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20155009 · Cited by 10
Cytokine profile of NALT during acute stress and its possible effect on IgA secretion
Gutiérrez-Meza, J. M., Luna, R. A. J., Rivera‐Aguilar, V., Miliar-García, Á., & Campos‐Rodríguez, R. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.04.016 · Cited by 10
Protection against renal ischemia–reperfusion injury through hormesis? Dietary intervention versus cold exposure
Shushimita, S., Grefhorst, A., Steenbergen, J., de Bruin, R. W. F., IJzermans, J. N. M., Themmen, A. P. N., & Dor, F. J. M. F. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.11.022 · Cited by 9
Memory Training Program Decreases the Circulating Level of Cortisol and Pro-inflammatory Cytokines in Healthy Older Adults
Pesce, M., Tatangelo, R., Fratta, I. L., Rizzuto, A., Campagna, G., Turli, C., Ferrone, A., Franceschelli, S., Speranza, L., Verrocchio, M. C., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00233 · Cited by 11
Sympathetic innervation suppresses the autophagic-lysosomal system in brown adipose tissue under basal and cold-stimulated conditions
Przygodda, F., Lautherbach, N. E. S., Buzelle, S. L., Gonçalves, D. A. P., de Assis, A. P., Paula-Gomes, S., Garófalo, M. A. R., Heck, L. C., Matsuo, F. S., Mota, R. F., et al. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00065.2019 · Cited by 9
Physiological and behavioural adjustment of a wild rodent to laboratory conditions
Carrilho, M., Monarca, R. I., Aparício, G., Mathias, M. D. L., Tapisso, J. T., & von Merten, S. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114385 · Cited by 10
Effect of rotation and immobilization stress on IL-1β, IL-2, IL-4, and IFN-γ production by splenocytes under opiate receptor blockade in vivo
Гейн, С. В., & Шаравьева, И. Л. (2014) · Doklady Biological Sciences · doi:10.1134/s0012496614010141 · Cited by 9
Effect of Early Stimulation on Some Immune Parameters in a Model of Prenatally Stressed Rats
Liaudat, A. C., Rodríguez, N., Vivas, A. B., Gauna, H. F., & Mayer, N. I. (2012) · International Journal of Psychological Studies · doi:10.5539/ijps.v4n3p73 · Cited by 9
Effects of long-term chronic stress on the lymphoid organs and blood leukocytes of the rat (Rattus norvegicus)
Divyashree, S., Sarjan, H. N., & Yajurvedi, H. N. (2015) · Canadian Journal of Zoology · doi:10.1139/cjz-2015-0150 · Cited by 10
Stress‐induced body weight loss and improvements in cardiometabolic risk factors do not translate to improved myocardial ischemic tolerance in western diet‐fed mice
Hatton‐Jones, K. M., Cox, A. J., Peart, J. N., Headrick, J. P., & Toit, E. F. D. (2022) · Physiological Reports · doi:10.14814/phy2.15170 · Cited by 8
The role of gut microbiota in chronic restraint stress-induced cognitive deficits in mice
Ling, Q., Zhang, J., Zhong, L., Li, X., Sun, T., Xiang, H., Manyande, A., Zhao, G., Shi, Y., & Zhu, Q. (2024) · BMC Microbiology · doi:10.1186/s12866-024-03435-w · Cited by 8
Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection
Young, E. E., Vichaya, E. G., Reusser, N. M., Cook, J. L., Steelman, A. J., Welsh, C. J., & Meagher, M. W. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.08.014 · Cited by 8
Mirogabalin prevents repeated restraint stress-induced dysfunction in mice
Iwai, T., Kikuchi, A., Oyama, M., Watanabe, S., & Tanabe, M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112506 · Cited by 8
Loss of Hepatic Surf4 Depletes Lipid Droplets in the Adrenal Cortex but Does Not Impair Adrenal Hormone Production
Chang, X., Zhao, Y., Qin, S., Wang, H., Wang, B., Zhai, L., Liu, B., Gu, H.-M., & Zhang, D. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.764024 · Cited by 7
Immunomodulating Effects of Cold Stress
Гейн, С. В., & Шаравьева, И. Л. (2018) · Biology Bulletin Reviews · doi:10.1134/s207908641806004x · Cited by 7
Reduced Mobility But Unaffected Startle Response in Female Rats Exposed to Prenatal Dexamethasone: Different Sides to a Phenotype
Kjaer, S. L., Wegener, G., Rosenberg, R., & Hougaard, K. S. (2010) · Developmental Neuroscience · doi:10.1159/000313914 · Cited by 7
Review : Clinical application and efficacy of herbal medicines by modulating cytokines in atopic dermatitis-induced animal model
Park, Y.-C., Lim, J. D., Park, Y.-K., Yoon, M.-S., & Lee, S. (2012) · The Korea Journal of Herbology · doi:10.6116/kjh.2012.27.4.33 · Cited by 6
Organ-specific changes in norepinephrine turnover against various stress conditions in thermoneutral mice.
Teramura, Y., Terao, A., Okada, Y., Tomida, J., Okamatsu‐Ogura, Y., & Kimura, K. (2014) · PubMed · doi:10.14943/jjvr.62.3.117 · Cited by 6
Serotonin Transporter in Lymphocytes of Rats Exposed to Physical Restraint Stress
Medina-Martel, M., Urbina, M., Fazzino, F., & Lima, L. (2013) · NeuroImmunoModulation · doi:10.1159/000353797 · Cited by 6
Profound hypothermia determines the anticonvulsant and neuroprotective effects of swim stress
Fournier, N. M., Galic, M. A., Kalynchuk, L. E., & Persinger, M. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.081 · Cited by 6
Timing-Dependent Effects of Restraint Stress on Eosinophilic Airway Inflammation in Mice
Georén, S. K., Höglund, C. O., Tcacencu, I., Wikström, A. C., & Stierna, P. (2008) · NeuroImmunoModulation · doi:10.1159/000151529 · Cited by 6
Effects of Psychological Stress on Multiple Sclerosis via HPA Axis-mediated Modulation of Natural Killer T Cell Activity
Gao, Y., Liu, W., Liu, P., Li, M., & Ni, B. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273315953240528075542 · Cited by 6
A myeloid Tet2-IL-1β axis modulates intestinal inflammation by restricting catecholaminergic stimulation of enterochromaffin cell differentiation
Sharma, D., Malik, A., Locher, V., McGrath, S., Zabala, S., Grover, H., Ciszewski, C., Chen, L., Yang, D., Chiu, I. M., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.10.012 · Cited by 6
FKBP5 mediates glucocorticoid signaling in estrogen deficiency-associated endothelial dysfunction
Zhu, R., Xu, Y., Li, H., He, C., Leung, F. P., Wang, L., & Wong, W. T. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177598 · Cited by 5
Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response
Aubrecht, T. G., Weil, Z. M., Salloum, B. A., Ariza, M. E., Williams, M. V., Reader, B. F., Glaser, R., Sheridan, J. F., & Nelson, R. J. (2015) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2015.511049 · Cited by 5
Self-citation
The transferability from rat subacute 4-week oral toxicity study to translational research exemplified by two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties
Kemmerling, J., Fehlert, E., Kuper, C. F., Rühl-Fehlert, C., Stropp, G. D., Vogels, J., Krul, C. A. M., & Vohr, H.-W. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.032 · Cited by 5
Effect of Opiate Receptors Blockade on Microbicidal Potential and Production of IL-1β, TNFα, and IL-10 by Peritoneal Macrophages under Stress Conditions
Гейн, С. В., & Шаравьева, И. Л. (2016) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-016-3409-z · Cited by 5
Neuroimmune Response Mediated by Cytokines in Natural Scrapie after Chronic Dexamethasone Treatment
Guijarro, I. M., Garcés, M., Andrés‐Benito, P., Marín, B., Otero, A., Barrio, T., Carmona, M., Ferrer, I., Badiola, J. J., & Monzón, M. (2021) · Biomolecules · doi:10.3390/biom11020204 · Cited by 5
Individualized Housing Modifies the Immune–Endocrine System in CD1 Adult Male Mice
Ortega-Saez, I., Díez-Solinska, A., Grífols, R., Martí, C. V., Zamora, C., Muñoz‐Culla, M., Vegas, Ó., & Azkona, G. (2023) · Animals · doi:10.3390/ani13061026 · Cited by 8
Partial removal of brown adipose tissue enhances humoral immunity in warm-acclimated Mongolian gerbils (Meriones unguiculatus)
Yang, D., Xu, Y., & Wang, D. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.10.012 · Cited by 5
Neuroimmune Response in Natural Preclinical Scrapie after Dexamethasone Treatment
Guijarro, I. M., Garcés, M., Marín, B., Otero, A., Barrio, T., Badiola, J. J., & Monzón, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165779 · Cited by 5
Differential long-term effects of physical, social, and psychological stressors in male mice: down-regulation of inflammatory markers and unresponsiveness of the antioxidant system
Balatskyi, V. A., Gospodaryov, D. V., Abrat, O., Strilbytska, O. M., Demianchuk, O., Tkachyk, A., Vasylyshyn, O., Lushchak, O. V., Lushchak, V. I., & Bayliak, M. M. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115065 · Cited by 7
Social defeat stimulates local glucocorticoid regeneration in lymphoid organs
Ergang, P., Mikulecká, A., Vodička, M., Vagnerová, K., Mikšı́k, I., & Pácha, J. (2018) · Endocrine Connections · doi:10.1530/ec-18-0319 · Cited by 5
Effects of an acute negative and positive stimulus on immune-related gene expression in the pituitary and head kidney of carp (Cyprinus carpio L.)
Pawlak, P., Konrad, J., Seitz, A., & Pietsch, C. (2024) · Aquaculture and Fisheries · doi:10.1016/j.aaf.2024.09.004 · Cited by 4
The Effects of Psychological Stressors on the Intestinal Microbiota
Bailey, M. T. (2009) · Bioscience and Microflora · doi:10.12938/bifidus.28.125 · Cited by 3
Effects of early and late adverse experiences on morpho-quantitative characteristics of Sprague-Dawley rat spleen subjected to stress during adulthood.
Vásquez, B., Sandoval, C., Smith, R. L., & del Sol, M. (2015) · Europe PMC (PubMed Central) · Cited by 4
Enduring Behavioral and Brain Impacts of Prenatal Stress and Childhood Adversity and Their Potential Multigenerational Consequences
Cory‐Slechta, D. A. (2018) · Advances in neurotoxicology · doi:10.1016/bs.ant.2018.03.007 · Cited by 4
Corticosterone rapidly improves the endurance of high-intensity exercise (swimming) via nongenomic mechanisms in mice
Gong, H., Liu, L., Su, W., Zhu, Z., Liu, Y., Lian, Y., Wei, P., Cao, Z., Zhang, T., & Jiang, C.-L. (2019) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.18.08456-6 · Cited by 4
ANTIDEPRESSANT LIKE EFFECT OF NEWLY SYNTHESIZED COMPOUND 2[(N- BENZYLACETAMIDO) MERCAPTO] BENZIMIDAZOLE (VS 25) AND ITS POSSIBLE MECHANISM BY INHIBITION OF MONOAMINE OXIDASE ENZYME IN MICE
Mute, V. M., & Bodhankar, S. L. (2014) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 3
Ibuprofen Protection Against Restrained Chronic Stress-induced Depression in Male Rats
Nozari, M., Nahavandi, A., Zeinivand, M., Eslami, M., Godarzi, M., Ahmadi, M., & Jamali-Raeufy, N. (2020) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.11.4.1775.2 · Cited by 3
Genotoxic effect of restraint and stress pheromone on somatic and germ cells of mouse males Mus musculus L.
Shcherbinina, V., Petrova, M. V., Glinin, T. S., & Даев, Е. В. (2021) · Ecological genetics · doi:10.17816/ecogen65208 · Cited by 3
Involvement of L-Selectin in Contact Hypersensitivity Responses Augmented by Auditory Stress
Bae, S. J., Shimizu, K., Yozaki, M., Yamaoka, T., Akiyama, Y., Yoshizaki, A., Muroi, E., Hara, T., Ogawa, F., & Sato, S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090322 · Cited by 3
Design, rationale and feasibility of a multidimensional experimental protocol to study early life stress
Bartholomeusz, M. D., Bolton, P. S., Callister, R., Skinner, V., & Hodgson, D. M. (2017) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2017.05.003 · Cited by 3
Research Article: The effects of psychological and physical stressors on the secretion of immunoglobulin A in humans and mice
Kohanski, K., & Redmond, S. (2017) · BIOS · doi:10.1893/bios-d-14-00035.1 · Cited by 1
Tyrosine hydroxylase-expressing neurons in the paraventricular nucleus of the hypothalamus regulate peripheral leukocytes during inflammatory pain
Li, X., Jia, Y., Yang, L., Peng, M., Xiong, M., Zhu, Q., Gao, Y., & Ke, C. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115241 · Cited by 2
Body weight modulates the impact of oxytocin on chronic cold-immobilization stress response
Önal, D., Korkmaz, H., Önal, G., & Pehli̇vanoğlu, B. (2024) · Peptides · doi:10.1016/j.peptides.2024.171202 · Cited by 2
Characterization of Highper, an ENU-induced mouse mutant with abnormal psychostimulant and stress responses
Eisener-Dorman, A. F., Bailey, J. S., Grabowski-Boase, L., Huitrón‐Reséndiz, S., Roberts, A. J., Wiltshire, T., & Tarantino, L. M. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2827-5 · Cited by 2
Effect of Restraint Stress Duration on Humoral Immune Response in Albino Rats: Modulation by Chlordiazepoxide
Suresh, P. S., Peroumal, D., Nanjaiah, N. D., & Koner, B. C. (2008) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923970802278235 · Cited by 2
Food hoarding, but not food intake, is attenuated by acute diazepam treatment in female Mongolian gerbils (Meriones unguiculatus)
Yang, H.-D., Wang, Q., & Wang, D. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.010 · Cited by 2
Pain and Distress
Karas, A. Z., & Silverman, J. (2014) · CRC Press eBooks · doi:10.1201/b17109-22 · Cited by 2
The Hematopoietic System: Evaluation and Data Interpretation in Nonclinical Safety Studies
Ramaiah, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64254-x · Cited by 2
Adaptive virtual reality stress training for spaceflight emergency procedures
Finseth, T. (2021) · doi:10.31274/td-20240329-40 · Cited by 3
Individual and Comorbid Influences of Chronic Stress and a Western Diet on Allostatic Loads and Cardiac Resilience, Adaptation and Proteome Profiles in Male Mice
Nicholas, M., Helman, T. J., Lyon, B., Naghipour, S., Ybanez, T., Ingles, J., Kim, C.-K., Stapelberg, N. J. C., Peart, J. N., Headrick, J. P., et al. (2025) · Comprehensive physiology · doi:10.1002/cph4.70045 · Cited by 1
Reproducibility and replicability in zebrafish behavioural neuroscience research: The importance of animal-human interaction and temporal aspects of husbandry conditions
Tsang, B., & Gerlai, R. T. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106712 · Cited by 1
Stressor‐ and Tissue‐Specific Regulation of the Corticotropin‐Releasing Factor System Across Epithelial Tissues in Rainbow Trout
Culbert, B. M., Pulford-Thorpe, A. E., Best, C., & Bernier, N. J. (2026) · The FASEB Journal · doi:10.1096/fj.202603109r · Cited by 1
Thermoneutrality Accelerates a Distinctive Metabolic Dysfunction–Associated Steatohepatitis Phenotype in a Diet-Induced Male Mouse Model With Similarities to Human Disease
Leke, R., Tan, J. Y., Ling, S., Siddiqui, M., Kakol‐Palm, D., Lindblom, A., Andréasson, A., Pellegrini, G., Söderberg, M. P., Zuydam, N. V., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101866 · Cited by 1
„Old Friends“, Immunregulation und Stressresilienz
Langgartner, D., Lowry, C. A., & Reber, S. O. (2020) · Nervenheilkunde · doi:10.1055/a-1037-0710 · Cited by 1
Pain and Distress
Karas, A. Z., & Silverman, J. (2014) · CRC Press eBooks · doi:10.1201/b16915-17 · Cited by 1
Sex difference effects of acute starvation on excitatory and inhibitory synapses on dopamine neurons
Arshad, S. H., Singh, A. K., Prasad, D., & Kumari, S. (2024) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20240311 · Cited by 1
Dynamics of somatostatin 4 receptor expression during chronic-stress loading and its potential as a chronic-stress marker
Abe, Y., Murase, T., Mitsuma, M., Shinba, Y., Yamashita, H., & Ikematsu, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-58621-7 · Cited by 1
Role of Melatonin in Intestinal Mucosal Injury Induced by Chronic Restraint Stress in Mice
Zhongxin, S., Lulu, C., Li, D., Yao, Y., Wenqian, Y., Hui, L., Shan, C., Xin, W., & Rutao, L. (2025) · Neuroendocrinology · doi:10.1159/000547254 · Cited by 1
The Role of Behavioural Toxicity in Risk Assessment
Weiss, B. (2009) · General, Applied and Systems Toxicology · doi:10.1002/9780470744307.gat059 · Cited by 1
Consequences of chronic psychosocial stress in male wistar rats
Nyuyki, K. D. (2013) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.27726 · Cited by 1
Examining an Animal Model of Depression with Recurrent Depression-like Episodes
Lebedeva, K. A. (2017) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 1
Papel da corticosterona na vigência do estresse sobre a função pineal em ratos.
Moraes, R. C. (2010) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2010.tde-18102010-153227

Authors: Bowers, S. L., Bilbo, S. D., Dhabhar, F. S., & Nelson, R. J.
Affiliations: The Ohio State University (US)
Stanford Medicine (US)
Corresponding author: Nelson, Randy J.
ORCID: Bowers, Stephanie L.
Bilbo, Staci D.
Dhabhar, Firdaus S.
Nelson, Randy J.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2008-01
Volume: 22
Issue: 1
Pages: 105-113
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2007.07.012
PMC: PMC2175078
OpenAlex: W1994862644
Cited by: 222
References: 55
Citations by year: 2026: 7 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 12 · 2019: 10 · 2018: 10 · 2017: 17 · 2016: 12 · 2015: 13 · 2014: 17 · 2013: 12 · 2012: 14
FWCI: 5.35
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
National Institutes of Health
National Institute of Mental Health (R01MH066144, MH-66144)
National Institute of Neurological Disorders and Stroke (P01NS020020)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: stressor specificity, corticosterone, glucocorticoid response, immune function, delayed-type hypersensitivity, lymphocyte migration, monocyte trafficking, restraint stress, forced swim test, social isolation, cold stress, handling, chronic stress, acute stress, psychoneuroimmunology
MeSH terms: Animals, Chronic Disease, Cold Temperature, Corticosterone, Handling, Psychological, Hypersensitivity, Delayed, Leukocyte Count, Male, Mice, Inbred C57BL, Monocytes, Osmolar Concentration, Restraint, Physical, Skin, Social Isolation, Stress, Physiological, Swimming, Volition, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Stressor-specific alterations in corticosterone and immune responses in mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks