Cited by 222Stress Responses and CortisolCancer, Stress, Anesthesia, and Immune ResponseNeuropeptides and Animal Physiology

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Stressor-specific alterations in corticosterone and immune responses in mice

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Bowers, Stephanie L., Bilbo, Staci D., Dhabhar, Firdaus S., Nelson, Randy J.·2008·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2007.07.012PMC PMC2175078

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Abstract

Different stressors likely elicit different physiological and behavioral responses. Previously reported differences in the effects of stressors on immune function may reflect qualitatively different physiological responses to stressors; alternatively, both large and subtle differences in testing protocols and methods among laboratories may make direct comparisons among studies difficult. Here we examine the effects of chronic stressors on plasma corticosterone concentrations, leukocyte redistribution, and skin delayed-type hypersensitivity (DTH), and the effects of acute stressors on plasma corticosterone and leukocyte redistribution. The effects of several commonly used laboratory stressors including restraint, forced swim, isolation, and low ambient temperatures (4 degrees C) were examined. Exposure to each stressor elevated corticosterone concentrations, with restraint (a putative psychological stressor) evoking a significantly higher glucocorticoid response than other stressors. Chronic restraint and forced swim enhanced the DTH response compared to the handled, low temperature, or isolation conditions. Restraint, low temperature, and isolation significantly increased trafficking of lymphocytes and monocytes compared to forced swim or handling. Generally, acute restraint, low temperature, isolation, and handling increased trafficking of lymphocytes and monocytes. Considered together, our results suggest that the different stressors commonly used in psychoneuroimmunology research may not activate the physiological stress response to the same extent. The variation observed in the measured immune responses may reflect differential glucocorticoid activation, differential metabolic adjustments, or both processes in response to specific stressors.

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(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,111
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Nishida, K., Kamizato, M., Kawai, T., Masuda, K., Takeo, K., Teshima-Kondo, S., Tanahashi, T., & Rokutan, K. (2009) · The FASEB Journal · doi:10.1096/fj.08-125005 · Cited by 22
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Authors: Bowers, S. L., Bilbo, S. D., Dhabhar, F. S., & Nelson, R. J.
Affiliations: The Ohio State University (US)
Stanford Medicine (US)
Corresponding author: Nelson, Randy J.
ORCID: Bowers, Stephanie L.
Bilbo, Staci D.
Dhabhar, Firdaus S.
Nelson, Randy J.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2008-01
Volume: 22
Issue: 1
Pages: 105-113
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2007.07.012
PMC: PMC2175078
OpenAlex: W1994862644
Cited by: 222
References: 55
Citations by year: 2026: 7 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 12 · 2019: 10 · 2018: 10 · 2017: 17 · 2016: 12 · 2015: 13 · 2014: 17 · 2013: 12 · 2012: 14
FWCI: 5.35
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
National Institutes of Health
National Institute of Mental Health (R01MH066144, MH-66144)
National Institute of Neurological Disorders and Stroke (P01NS020020)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: stressor specificity, corticosterone, glucocorticoid response, immune function, delayed-type hypersensitivity, lymphocyte migration, monocyte trafficking, restraint stress, forced swim test, social isolation, cold stress, handling, chronic stress, acute stress, psychoneuroimmunology
MeSH terms: Animals, Chronic Disease, Cold Temperature, Corticosterone, Handling, Psychological, Hypersensitivity, Delayed, Leukocyte Count, Male, Mice, Inbred C57BL, Monocytes, Osmolar Concentration, Restraint, Physical, Skin, Social Isolation, Stress, Physiological, Swimming, Volition, Mice

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Stressor-specific alterations in corticosterone and immune responses in mice

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