The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Stressor-specific alterations in corticosterone and immune responses in mice
Open accessAbstract
Different stressors likely elicit different physiological and behavioral responses. Previously reported differences in the effects of stressors on immune function may reflect qualitatively different physiological responses to stressors; alternatively, both large and subtle differences in testing protocols and methods among laboratories may make direct comparisons among studies difficult. Here we examine the effects of chronic stressors on plasma corticosterone concentrations, leukocyte redistribution, and skin delayed-type hypersensitivity (DTH), and the effects of acute stressors on plasma corticosterone and leukocyte redistribution. The effects of several commonly used laboratory stressors including restraint, forced swim, isolation, and low ambient temperatures (4 degrees C) were examined. Exposure to each stressor elevated corticosterone concentrations, with restraint (a putative psychological stressor) evoking a significantly higher glucocorticoid response than other stressors. Chronic restraint and forced swim enhanced the DTH response compared to the handled, low temperature, or isolation conditions. Restraint, low temperature, and isolation significantly increased trafficking of lymphocytes and monocytes compared to forced swim or handling. Generally, acute restraint, low temperature, isolation, and handling increased trafficking of lymphocytes and monocytes. Considered together, our results suggest that the different stressors commonly used in psychoneuroimmunology research may not activate the physiological stress response to the same extent. The variation observed in the measured immune responses may reflect differential glucocorticoid activation, differential metabolic adjustments, or both processes in response to specific stressors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Notably, the HPA-axis and inflammatory arm of the immune system respond and habituate differently to various types of stressors (Bowers et al., 2008; Kant et al., 1985; Kuhlman et al., 2014; Pacák, 1999; Pacák et al., 1998, 1995; Sheridan and McLaughlin, 2014; Weiner,”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Bowers et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092
Immunobiology: the immune system in health and disease
(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,111
The concept of allostasis in biology and biomedicine
McEwen, B. S., & Wingfield, J. C. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00024-7 · Cited by 3,302 · cited 1×
“N IH -PA Author M anuscript N IH -PA Author M anuscript physiological mechanisms are engaged to restore homeostasis by a process termed “allostasis” (Dhabhar et al., 2000; McEwen, 1998; McEwen and Wingfield, 2003; Schulkin et al., 1994).”
Stress and the General Adaptation Syndrome
Selye, H. (1950) · BMJ · doi:10.1136/bmj.1.4667.1383 · Cited by 1,481
Dhabhar, F. S., & McEwen, B. S. (1997) · Brain Behavior and Immunity · doi:10.1006/brbi.1997.0508 · Cited by 1,014
Self-citationStressor specificity of central neuroendocrine responses: implications for stress-related disorders
Pacák, K., & Palkovits, M. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0436 · Cited by 926
Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms.
Dhabhar, F. S., Miller, A. H., McEwen, B. S., & Spencer, R. L. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.5511 · Cited by 730
Self-citation(2004) · PubMed · Cited by 681
Animal models of anxiety and depression: how are females different?
Palanza, P. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00010-0 · Cited by 559
Dayas, C. V., Buller, K. M., Crane, J. W., Xu, Y., & Day, T. A. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01733.x · Cited by 514
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–222 of 222
SEROTONERGIC MECHANISMS IN ATOPIC DERMATITIS
Rasul, A. (2012) · Figshare
Endogenous and exogenous glucocorticoid effects in a model of allergic airway inflammation.
Georén, S. K. (2008) · Figshare
CB1 Receptor Activity Modulates Responses in the Forced Swim Test and Open Field Test Paradigms
Culmer, T. L. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/xbhk-ww89
The Influence of Olive Oil on the Lipidemic Profile in Stress
Kotsiou, A., & Tesseromatis, C. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374420-3.00093-0
Mummert, M. E. (2016) · Springer eBooks · doi:10.1007/978-3-319-43157-4_21
Lum, W., & Min, C. (2016) · TSpace (University of Toronto)
Semenova, Y.-M., Kyryk, V. M., Nikolsky, I. S., & Butenko, G. M. (2019) · Fìzìologìčnij žurnal · doi:10.15407/fz65.04.003
Lange, M. (2020) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-m3b8-rd29
Overlapping Neural Substrates of Alcohol- and Anxiety-Related Behavior in the Rat
Barchiesi, R. (2021) · Linköping University medical dissertations · doi:10.3384/diss.diva-174707
Horváth, K., Juhász, B., Kuti, D., Ferenczi, S., Török, B., Zelena, D., & Kovács, K. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.20.477065
Faculty Opinions recommendation of Olfactory deficits cause anxiety-like behaviors in mice.
Ressler, K. J., & Dias, B. G. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.716197992.791652821
Stress-induced immune deviations and reproductive failure
Wöhrle, R., Arck, P., & Thiele, K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90805-4.00013-4
It’s getting hot in here: The interface between obesity, influenza, and thermoneutrality
O’Dwyer, D. N., & Hogan, S. P. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.10.003
The Gut Microbiome-Induced Changes in Brain Immune System and Their Role in Epilepsy
Govindan, R., Poomarimuthu, M., Arumugam, S. N., Kalimuthu, S., Jayaraman, S., & Christudass, C. S. (2024) · Springer eBooks · doi:10.1007/978-981-99-8803-7_14
The Hematopoietic System: Evaluation and Data Interpretation in Nonclinical Safety Studies
Naor, A. W., & Ramaiah, L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00180-7
De l’importance des médiateurs du stress dans le contrôle de l’immunité
Bacou, E. (2017) · theses.fr (ABES) · doi:10.70675/c3e20630z2e84z4f0ez9c4ez2ff5647f0f03
Shaver, A. A., Kerman, E. M., Oh, H., Lu, C., Samuel, I. B. H., Brewster, R. C., Reinhard, M. J., Reggia, J. A., Purtilo, J. M., & Gentili, R. J. (2026) · Ergonomics · doi:10.1080/00140139.2026.2614629
EmoLoop: An adaptive VR biofeedback system for stress regulation
Lima, R., Chirico, A., Gaggioli, A., Gamboa, H. F. S., & Badia, S. B. I. (2026) · International Journal of Human-Computer Studies · doi:10.1016/j.ijhcs.2026.103916
Caloric restriction and neuropsychiatric phenotypes: A critical review of preclinical data
Anousi, E., & Filiou, M. D. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.107001
Stress-encoding neurons in the lateral habenula promote humoral immunity under eustress
Liu, X., Wang, X., Chen, X., Lyu, Y., Fang, Y., Su, Y., Zhou, H., Yang, Y., Hu, Z., Tian, H., et al. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.107086
Hall, J. M. F. (2013) · Digital Commons @ UNT Health Science Center
Metadata
- Authors
- Bowers, S. L., Bilbo, S. D., Dhabhar, F. S., & Nelson, R. J.
- Affiliations
- The Ohio State University (US)
- Stanford Medicine (US)
- Corresponding author
- Nelson, Randy J.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 22
- Issue
- 1
- Pages
- 105-113
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC2175078
- OpenAlex
- W1994862644
- Cited by
- 222
- References
- 55
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 12 · 2019: 10 · 2018: 10 · 2017: 17 · 2016: 12 · 2015: 13 · 2014: 17 · 2013: 12 · 2012: 14
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- National Institute of Mental Health (R01MH066144, MH-66144)
- National Institute of Neurological Disorders and Stroke (P01NS020020)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- stressor specificity, corticosterone, glucocorticoid response, immune function, delayed-type hypersensitivity, lymphocyte migration, monocyte trafficking, restraint stress, forced swim test, social isolation, cold stress, handling, chronic stress, acute stress, psychoneuroimmunology
- MeSH terms
- Animals, Chronic Disease, Cold Temperature, Corticosterone, Handling, Psychological, Hypersensitivity, Delayed, Leukocyte Count, Male, Mice, Inbred C57BL, Monocytes, Osmolar Concentration, Restraint, Physical, Skin, Social Isolation, Stress, Physiological, Swimming, Volition, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
