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Cited by 242

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients

Open access
Lutgendorf, Susan K., DeGeest, Koen, Dahmoush, Laila, Farley, Donna, Penedo, Frank, Bender, David, Goodheart, Michael, Buekers, Thomas E., Mendez, Luis, Krueger, Gina, Clevenger, Lauren, Lubaroff, David M., Sood, Anil K., Cole, Steve W.·2011·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2010.10.012
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Abstract

Noradrenergic pathways have been implicated in growth and progression of ovarian cancer. Intratumoral norepinephrine (NE) has been shown to increase with stress in an animal cancer model, but little is known regarding how tumor NE varies with disease stage and with biobehavioral factors in ovarian cancer patients. This study examined relationships between pre-surgical measures of social support, depressed mood, perceived stress, anxiety, tumor histology and tumor catecholamine (NE and epinephrine [E]) levels among 68 ovarian cancer patients. We also examined whether associations observed between biobehavioral measures and tumor catecholamines extended to other compartments. Higher NE levels were found in advanced stage (p=0.006) and higher grade (p=0.001) tumors. Adjusting for stage, grade, and peri-surgical beta blockers, patients with a perceived lack of social support had significantly higher tumor NE (β = −0.29, p=0.012). A similar trend was seen for social support and ascites NE (adjusting for stage, peri-surgical beta blockers and caffeine: β=−0.50, p=0.075), but not for plasma NE. Other biobehavioral factors were not related to tumor, ascites, or plasma NE (p values > 0.21). Tumor E was undetectable in the majority of tumors and thus E was not further analyzed. In summary, these results suggest that tumor NE provides distinct information from circulating plasma concentrations. Tumor NE levels were elevated in relationship to tumor grade and stage. Low subjective social support was associated with elevated intratumoral NE. As beta-adrenergic signaling is related to key biological pathways involved in tumor growth, these findings may have implications for patient outcomes in ovarian cancer.

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Metadata

Authors
Lutgendorf, S. K., DeGeest, K., Dahmoush, L., Farley, D., Penedo, F., Bender, D., Goodheart, M., Buekers, T. E., Mendez, L., Krueger, G., Clevenger, L., Lubaroff, D. M., Sood, A. K., & Cole, S. W.
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2011-02
Volume
25
Issue
2
Pages
250-255
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2010.10.012
OpenAlex
W2014334618
Cited by
242
References
14
FWCI
6.38
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. https://app.cochat.ai/papers/10.1016/j.bbi.2010.10.012
The paper
Lutgendorf, S. K., DeGeest, K., Dahmoush, L., Farley, D., Penedo, F., Bender, D., Goodheart, M., Buekers, T. E., Mendez, L., Krueger, G., Clevenger, L., Lubaroff, D. M., Sood, A. K., & Cole, S. W. (2011). Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2010.10.012

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.