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Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects
Abstract
BACKGROUND AND AIMS Mood and cognition alterations play a role in the motivation for alcohol-drinking. Lipopolysaccharides are known to stimulate inflammation that was shown to induce mood and cognitive changes in rodents and humans. Enhanced intestinal permeability and elevated blood LPS characterize alcohol-dependent mice. However, no data have been published in non-cirrhotic humans. Our first goal was to test whether intestinal permeability, blood LPS and cytokines are increased in non-cirrhotic alcohol-dependent subjects before withdrawal and if they recover after withdrawal. Our second goal was to test correlations between these biochemical and the behavioral variables to explore the possibility of a role for a gut-brain interaction in the development of alcohol-dependence. METHODS Forty alcohol-dependent-subjects hospitalized for a 3-week detoxification program were tested at onset (T1) and end (T2) of withdrawal and compared for biological and behavioral markers with 16 healthy subjects. Participants were assessed for gut permeability, systemic inflammation (LPS, TNFα, IL-6, IL-10, hsCRP) and for depression, anxiety, alcohol-craving and selective attention. RESULTS Intestinal permeability and LPS were largely increased in alcohol-dependent subjects at T1 but recovered completely at T2. A low-grade inflammation was observed at T1 that partially decreased during withdrawal. At T1, pro-inflammatory cytokines were positively correlated with craving. At T2 however, the anti-inflammatory cytokine IL-10 was negatively correlated with depression, anxiety and craving. CONCLUSION Leaky gut and inflammation were observed in non-cirrhotic alcohol-dependent subjects and inflammation was correlated to depression and alcohol-craving. This suggests that the gut-brain axis may play a role in the pathogenesis of alcohol-dependence.
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“Given the links between impaired gastrointestinal health and neuroinflammation (145), targeted nutrition interventions may ameliorate neuroinflammation, which has been identified as a potential treatment for OUD (78).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [145]
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Self-citation
Metadata
- Authors
- Leclercq, S., Cani, P. D., Neyrinck, A. M., Stärkel, P., Jamar, F., Mikolajczak, M., Delzenne, N. M., & de Timary, P.
- Affiliations
- UCLouvain (BE)
- Cliniques Universitaires Saint-Luc (BE)
- Corresponding author
- Delzenne, Nathalie M.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 26
- Issue
- 6
- Pages
- 911-918
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W1705992573
- Semantic Scholar
- 0e7b0f2e0da0290af9f83f26dab1524da03a8e77
- Cited by
- 310
- References
- 61
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 28 · 2023: 20 · 2022: 25 · 2021: 41 · 2020: 30 · 2019: 29 · 2018: 27 · 2017: 20 · 2016: 18 · 2015: 10 · 2014: 12 · 2013: 4 · 2012: 2
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Alcohol and Alcoholism
- Funders
- Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- alcoholism, intestinal permeability, leaky gut, lipopolysaccharide, systemic inflammation, gut-brain axis, alcohol craving, depression, anxiety, cytokines, IL-10, TNF-α, interleukin-6, alcohol withdrawal, selective attention, non-cirrhotic patients
- MeSH terms
- Alcoholism, Anxiety, Attention, C-Reactive Protein, Chromium Radioisotopes, Depression, Edetic Acid, Enteritis, Female, Humans, Intestines, Lipopolysaccharides, Male, Middle Aged, Neuropsychological Tests, Obsessive Behavior, Permeability, Reaction Time, Substance Withdrawal Syndrome, Body Mass Index, Cytokines, Diagnostic and Statistical Manual of Mental Disorders
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