Cited by 310Alcohol Consumption and Health EffectsTryptophan and brain disordersSubstance Abuse Treatment and Outcomes

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Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects

Leclercq, Sophie, Cani, Patrice D., Neyrinck, Audrey M., Stärkel, Peter, Jamar, François, Mikolajczak, Moïra, Delzenne, Nathalie M., de Timary, Philippe·2012·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2012.04.001

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Abstract

BACKGROUND AND AIMS Mood and cognition alterations play a role in the motivation for alcohol-drinking. Lipopolysaccharides are known to stimulate inflammation that was shown to induce mood and cognitive changes in rodents and humans. Enhanced intestinal permeability and elevated blood LPS characterize alcohol-dependent mice. However, no data have been published in non-cirrhotic humans. Our first goal was to test whether intestinal permeability, blood LPS and cytokines are increased in non-cirrhotic alcohol-dependent subjects before withdrawal and if they recover after withdrawal. Our second goal was to test correlations between these biochemical and the behavioral variables to explore the possibility of a role for a gut-brain interaction in the development of alcohol-dependence. METHODS Forty alcohol-dependent-subjects hospitalized for a 3-week detoxification program were tested at onset (T1) and end (T2) of withdrawal and compared for biological and behavioral markers with 16 healthy subjects. Participants were assessed for gut permeability, systemic inflammation (LPS, TNFα, IL-6, IL-10, hsCRP) and for depression, anxiety, alcohol-craving and selective attention. RESULTS Intestinal permeability and LPS were largely increased in alcohol-dependent subjects at T1 but recovered completely at T2. A low-grade inflammation was observed at T1 that partially decreased during withdrawal. At T1, pro-inflammatory cytokines were positively correlated with craving. At T2 however, the anti-inflammatory cytokine IL-10 was negatively correlated with depression, anxiety and craving. CONCLUSION Leaky gut and inflammation were observed in non-cirrhotic alcohol-dependent subjects and inflammation was correlated to depression and alcohol-craving. This suggests that the gut-brain axis may play a role in the pathogenesis of alcohol-dependence.

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Authors: Leclercq, S., Cani, P. D., Neyrinck, A. M., Stärkel, P., Jamar, F., Mikolajczak, M., Delzenne, N. M., & de Timary, P.
Affiliations: UCLouvain (BE)
Cliniques Universitaires Saint-Luc (BE)
Corresponding author: Delzenne, Nathalie M.
ORCID: Leclercq, Sophie
Cani, Patrice D.
Neyrinck, Audrey M.
Mikolajczak, Moïra
Delzenne, Nathalie M.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2012-08
Volume: 26
Issue: 6
Pages: 911-918
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2012.04.001
OpenAlex: W1705992573
Semantic Scholar: 0e7b0f2e0da0290af9f83f26dab1524da03a8e77
Cited by: 310
References: 61
Citations by year: 2026: 17 · 2025: 27 · 2024: 28 · 2023: 20 · 2022: 25 · 2021: 41 · 2020: 30 · 2019: 29 · 2018: 27 · 2017: 20 · 2016: 18 · 2015: 10 · 2014: 12 · 2013: 4 · 2012: 2
FWCI: 6.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Alcohol and Alcoholism
Funders: Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: alcoholism, intestinal permeability, leaky gut, lipopolysaccharide, systemic inflammation, gut-brain axis, alcohol craving, depression, anxiety, cytokines, IL-10, TNF-α, interleukin-6, alcohol withdrawal, selective attention, non-cirrhotic patients
MeSH terms: Alcoholism, Anxiety, Attention, C-Reactive Protein, Chromium Radioisotopes, Depression, Edetic Acid, Enteritis, Female, Humans, Intestines, Lipopolysaccharides, Male, Middle Aged, Neuropsychological Tests, Obsessive Behavior, Permeability, Reaction Time, Substance Withdrawal Syndrome, Body Mass Index, Cytokines, Diagnostic and Statistical Manual of Mental Disorders

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Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects

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