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Neuroendocrine influences on cancer progression
Open accessAbstract
During the past decade, new studies have continued to shed light on the role of neuroendocrine regulation of downstream physiological and biological pathways relevant to cancer growth and progression. More specifically, our knowledge of the effects of the sympathetic nervous system (SNS) on cancer biology has been greatly expanded by new data demonstrating how the cellular immune response, inflammatory processes, tumor-associated angiogenesis, and tumor cell invasion and survival converge to promote tumor growth. This review will summarize these studies, while synthesizing clinical, cellular and molecular research that has continued to unearth the biological events mediating the interplay between SNS-related processes and cancer progression.
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“and earlier cancer-related mortality [20–22]”
From A randomized controlled trial of a multi-modal palliative care intervention to promote advance care planning and psychological well-being among adults with advanced cancer: study protocol. (2022) · cites this paper as [21]
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Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733 · cited 1×
“In this review, we will focus on chronic stress conditions that keep the body in a constant state of ‘‘overdrive’’, leading to deleterious downstream effects, deregulating the stress response and negatively affecting many organs systems (McEwen, 1998).”
BackgroundThe pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686 · cited 2×
“Tumor cells must perform these steps while evading immune system surveillance, and the cells that fail in any of these tasks cannot metastasize (Fidler, 2003).”
BackgroundStress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190 · cited 2×
“Besides catecholamines, glucocorticoids are also involved in the stress response and can control many normal physiological activities such as circadian rhythms, immune function and restoration of homeostasis (Glaser and Kiecolt-Glaser, 2005).”
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Self-citationThe influence of bio-behavioural factors on tumour biology: pathways and mechanisms
Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., & Sood, A. K. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1820 · Cited by 981 · cited 6×
“Several studies have shown that the effect of stress hormones on cancer cell proliferation varies according to the specific hormone influences and the tumor type studied (as reviewed in Antoni et al., 2006).”
BackgroundInfluentialSelf-citationNeuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957 · cited 2×
“…disease have shown that tumor incidence and progression can be exacerbated by chronic stressors, mainly through the reduction of type 1 cytokines and T cell and natural killer cell activity resulting in impaired antigen presentation and higher numbers of regulatory T cells (Webster et al., 2002).”
BackgroundThe sympathetic nervous system induces a metastatic switch in primary breast cancer
Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930
Self-citationMaximizing mouse cancer models
Frese, K. K., & Tuveson, D. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2192 · Cited by 728 · cited 1×
“Various approaches have been used to model disease (Frese and Tuveson, 2007).”
MethodMolecular Pathways: Beta-Adrenergic Signaling in Cancer
Cole, S. W., & Sood, A. K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0641 · Cited by 713 · cited 2×
“ADRBs are the key components of the stress signaling pathway, and data now suggest that they also play a major role in protumoral signaling pathways (Cole and Sood, 2012).”
BackgroundSelf-citationEpac proteins: multi-purpose cAMP targets
Bos, J. L. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.10.002 · Cited by 532 · cited 1×
“Furthermore, it has been demonstrated that isoproterenol can promote ovarian cancer cell movement and adhesion via laminin-5 through an Epac1 dependent pathway (Bos, 2006).”
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Items 101–145 of 145
Parra, M. T., Esmeaeli, N., Kohn, J. N., Henry, B. L., Klagholz, S. D., Jain, S., Pruitt, C., Vicario, D., Jonas, W. B., & Mills, P. J. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420921439 · Cited by 3
“7%); (9) chemotherapy and radiotherapy (2.”
BackgroundAgranovich, I., Borisova, E. G., Наволокин, Н. А., Bucharskaya, A. B., Maslyakova, G. N., Shirokov, A. A., Abdurashitov, A. S., Ангелов, И., Khorovodov, A. P., Terskov, A. V., et al. (2019) · Biomedical Optics Express · doi:10.1364/boe.10.004115 · Cited by 3
Adrenergic signaling and cancer: Deciphering the connections
Melhem‐Bertrandt, A., & Sood, A. K. (2013) · Cancer Biomarkers · doi:10.3233/cbm-130333 · Cited by 3
“an innocent bystander, but rather an intricate involvement in driving tumor growth and progression [8].”
BackgroundSelf-citationVerza, F. A., Santos‐Sousa, A. L., Oliveira, S. H. P., & Bernabé, D. G. (2025) · Endocrine Oncology · doi:10.1530/eo-24-0076 · Cited by 2
Heyda, A., Gdowicz‐Kłosok, A., Bugowska, M., Krzempek, M., Dębiec, K., Mrochem‐Kwarciak, J., & Składowski, K. (2025) · Cancers · doi:10.3390/cancers17223690 · Cited by 2
stress, A. C. A. U., support, W. A. I. P. S., & [22]., C. D. F. G. P. (2015) · Integrative Cancer Science and Therapeutics · doi:10.15761/icst.1000125 · Cited by 3
“Immunity: Catecholamine could effect on the immune system, reducing type1 cytokine, T cells and natural killer cell activity, enabling tumor cells to avoid elimination [33].”
BackgroundPatel, H. G., Kumar, A., Shah, N., Eris, E., Maroules, M., Baddoura, W., & DeBari, V. A. (2015) · North American Journal of Medicine and Science · Cited by 2
Psychological profile of breast cancer patients-sample from al-Resafa / Baghdad
Al-Shatari, S. A. E. (2022) · The Medical Journal of Basrah University · doi:10.33762/mjbu.2022.132513.1093 · Cited by 2
Sexual well-being and diurnal cortisol after prostate cancer treatment
Hoyt, M. A., Gaffey, A. E., Wang, A. W., Litwin, M. S., & Lawsin, C. R. (2018) · Journal of Health Psychology · doi:10.1177/1359105318772655 · Cited by 2
“…clinical attention is being given to biobehavioral models of cancer adjustment, stress, and disease course, and dysregulation in the HPA axis is associated with poorer psychological adjustment and cancer progression (Armaiz-Pena et al., 2013; Fagundes et al., 2017; Giese-Davis et al., 2006).”
Boggero, I. A., & Segerstrom, S. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397045-9.00140-3 · Cited by 2
Improving Cancer Survival Through Perioperative Attenuation of Adrenergic-Inflammatory Signaling
Ricon‐Becker, I., Hiller, J. G., & Ben‐Eliyahu, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-69584-8.00009-8 · Cited by 1
Immune System and Pituitary Tumors: TILs Death tears them Apart. A Review
Leon, E. J. (2015) · Journal of Cytology & Histology · doi:10.4172/2157-7099.1000332
“The primary initiating cause for these events remains elusive, although several transgenic mouse models have demonstrated that either inactivated or over expressed cell cycle regulators are sufficient to initiate pituitary tumorigénesis [4,5,8,22].”
BackgroundSchramm, H. M. (2019) · Der Merkurstab · doi:10.14271/dms-21162-de · Cited by 1
Case report: Study of a bulky melanoma mimicking sarcoma
Quack, E., Fatouaki, H., Afri, E., Mastronicola, R., & Dolivet, G. (2025) · International Journal of Surgery Case Reports · doi:10.1016/j.ijscr.2025.110923 · Cited by 1
de Oliveira, C. P., de Moraes, M. A., & de Moura, T. C. (2016) · Universitas Ciências da Saúde · doi:10.5102/ucs.v14i2.3910 · Cited by 1
Neuroimmunoendocrine Interactions in Tumorigenesis and Breast Cancer
Ruiz‐Manzano, R. A., Ochoa-Mercado, T. D. L., Mendoza, M. S., Castro, K. E. N., Arreola, M. I. P., & Morales‐Montor, J. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88128 · Cited by 1
Kaje, K. C., D’silva, F., Latha, T., Sanal, T. S., D’Souza, C., & Kumar, S. (2022) · Journal of Health and Allied Sciences NU · doi:10.1055/s-0042-1755583 · Cited by 1
Distress, circadian rhythms, immunity, and survival in presurgical breast cancer patients.
Rebholz, W. N. (2016) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2610 · Cited by 1
Kapfhammer, H. (2023) · Springer eBooks · doi:10.1007/978-3-662-68309-5_5 · Cited by 1
Integrative model of lifestyle effects on cancer via the HbA1c biomarker
de Beer, & Catharina, J. (2014)
Filho, W. M. Q. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2013.tde-26062013-144044
Environment, Epigenetic, and Disease: The Modifiable Trilogy
Pelligrino, N. E., Mohler, M. C., Uddo, R. B., Lovas, D., SOTHERN, M. S., Scribner, R. A., & Zabaleta, J. (2015) · Molecular and integrative toxicology · doi:10.1007/978-1-4471-6678-8_13
A challenging breast cancer type; Differentiation to neuroendocrine tumors
Yıldız, Ö., & Başak, F. (2017) · Journal of Surgery and Medicine · doi:10.28982/josam.342305
“The main types of these cancer types are identified according to positive markers and the majority of cell differentiation as solid, large cell or small cell [10-12].”
BackgroundRelational Processes in Support-Related Communication Among Young Adults with Cancer
Darabos, K. (2019) · CUNY Academic Works (City University of New York)
Lopes, L. C. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.22.2019.tde-31072019-125447
dos Santos, J. C. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2020.tde-20112018-110709
Jośko-Ochojska, J., & Brus, R. (2020) · Annales Academiae Medicae Silesiensis · doi:10.18794/aams/117864
Pathology and Molecular Mechanisms of Perineural Spread of Tumors
Sayyed, Y., Ji, R., Zaheer, T., & Li, L. (2021) · Medical Research Archives · doi:10.18103/mra.v9i6.2457
The complexity of cancer immunotherapy illustrated through skin tumors
Vieco-Martí, I., López-Carrasco, A., de la Cruz‐Merino, L., Noguera, R., & Naranjo, T. Á. (2022) · The International Journal of Biological Markers · doi:10.1177/03936155221088884
Kapfhammer, H. (2022) · Springer eBooks · doi:10.1007/978-3-662-65873-4_12
Systemic Onco-Sphere: Host Neuronal System in Cancer
Saw, P. E., & Song, E. (2023) · Springer eBooks · doi:10.1007/978-981-99-1183-7_23
Ernährung als natürlicher Schutz vor einer Krebserkrankung
Schramm, H. M. (2023) · Elsevier eBooks · doi:10.1016/b978-3-437-55097-3.00001-6
(2023) · Elsevier eBooks · doi:10.1016/b978-3-437-55097-3.09999-3
Verza, F. A., Santos‐Sousa, A. L., Oliveira, S. H. P., & Bernabé, D. G. (2024) · Research Square · doi:10.21203/rs.3.rs-3934938/v1
Alimujiang, A., Strecher, V. J., McLean, K., Mondul, A. M., Pearce, C. L., & Mukherjee, B. (2024) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-024-02717-y
“One potential causal pathway between psychosocial wellbeing and health is the neuroendocrine regulation of stress responses [12, 13].”
Stress as a Factor Stimulating Cancer Progression and Metastasis and Increasing Cancer Mortality
Mravec, B. (2024) · Springer eBooks · doi:10.1007/978-3-031-68590-3_35
Decisional conflict and physiological dysregulation among adolescents and young adults with cancer
Darabos, K., Barakat, L. P., & Schwartz, L. A. (2025) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2025.2515064
“25,26 Therefore, our results demonstrating an attenuated CAR given high decisional conflict highlight the clinically relevant implications of experiencing decisional conflict within cancer-related decisions.”
A Look into Stress Studies in Latin America
Caycho‐Rodríguez, T., Baños-Chaparro, J., & Torales, J. C. (2025) · Springer eBooks · doi:10.1007/978-3-031-84433-1_16
Fang, C. Y., Macfarlane, A. W., Fung, H. C. H., Khan, N., Barta, S. K., Hasler, J., Ballard, H. J., Landsburg, D. J., Nasta, S. D., Schuster, S. J., et al. (2026) · Cancer Medicine · doi:10.1002/cam4.71903
Chronic stress and myeloid immunosuppression in cancer: A neuroimmune link to behavioral dysfunction
Rivera-López, Y. A., Meléndez-Rodríguez, L. L., Torres-Rodríguez, O. I., Rivera-Pérez, L. M., Torres-Rosado, A. P., Tworoger, S. S., & Armaiz-Peña, G. N. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101322
Zhou, L., Ren, Y., Han, L., Wang, X., & Zhang, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1927701
Priyanka, H. P., Pratap, U. P., Nair, R. S., Ponnan, S. M., Vasantharekha, R., Hannah, L. E., & ThyagaRajan, S. (2026) · Medical Oncology · doi:10.1007/s12032-026-03408-1
“Metastatic progression is driven by the activation of both hormonal and adrenergic signals, which converge on over-lapping downstream pathways, including the extracellular signal-regulated kinase (ERK) and cyclic AMP response element-binding protein (CREB) pathways [ 10 , 27].”
Patrad, E., & Alizadeh, A. M. (2026) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2026.105083
Environmental Manipulation and Neuropeptide Effects on Energy Balance and Cancer
Cao, L. (2015) · Energy balance and cancer · doi:10.1007/978-3-319-16733-6_2
“Downstream activation of the SAM and HPA axes exerts selective physiologic pressures that initiate molecular signaling pathways involved in DNA repair, cell survival, angiogenesis, inflammation, invasion, metastasis, and drug resistance [6, 98, 99].”
Background
Metadata
- Authors
- Armaiz-Pena, G. N., Cole, S. W., Lutgendorf, S. K., & Sood, A. K.
- Affiliations
- University of California, Los Angeles (US)
- University of Iowa (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Sood, Anil K.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 30
- Pages
- S19-S25
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3467346
- OpenAlex
- W2113048638
- Cited by
- 145
- References
- 72
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 18 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 19 · 2014: 6 · 2013: 7
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 109298, R01CA110793, U54CA151668, CA 110793, CA-104825, R01CA109298, CA140933, R01CA104825, R01CA140933, P50CA083639, P30CA016672)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- neuroendocrine regulation, tumor progression, sympathetic nervous system, tumor growth, cell-mediated immunity, inflammation, tumor angiogenesis, tumor invasion, tumor cell survival
- MeSH terms
- Animals, Humans, Neoplasms, Neovascularization, Pathologic, Neurosecretory Systems, Disease Progression
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