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Neuroendocrine influences on cancer progression
Open accessAbstract
During the past decade, new studies have continued to shed light on the role of neuroendocrine regulation of downstream physiological and biological pathways relevant to cancer growth and progression. More specifically, our knowledge of the effects of the sympathetic nervous system (SNS) on cancer biology has been greatly expanded by new data demonstrating how the cellular immune response, inflammatory processes, tumor-associated angiogenesis, and tumor cell invasion and survival converge to promote tumor growth. This review will summarize these studies, while synthesizing clinical, cellular and molecular research that has continued to unearth the biological events mediating the interplay between SNS-related processes and cancer progression.
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“and earlier cancer-related mortality [20–22]”
From A randomized controlled trial of a multi-modal palliative care intervention to promote advance care planning and psychological well-being among adults with advanced cancer: study protocol. (2022) · cites this paper as [21]
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Citations
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Background
Cited by
Sorted by citations
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BackgroundDepression in cancer: The many biobehavioral pathways driving tumor progression
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Eckerling, A., Ricon-Becker, I., Sorski, L., Sandbank, E., & Ben-Eliyahu, S. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00395-5 · Cited by 348
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“Nerve fibers present in and around most tissues and organs, as well as tumors (13, 16, 17), release neurotransmitters and other neuropeptides locally and systemically.”
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BackgroundSelf-citationSrc activation by β-adrenoreceptors is a key switch for tumour metastasis
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Self-citationThe Impact of Everyday Stressors on the Immune System and Health
Seiler, A., Fagundes, C. P., & Christian, L. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-16996-1_6 · Cited by 169
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Self-citationNeuroimmunology of Behavioral Comorbidities Associated With Cancer and Cancer Treatments
dos Santos, J. C., & Pyter, L. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01195 · Cited by 123
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BackgroundDexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancers
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BackgroundReview of yoga therapy during cancer treatment
Danhauer, S. C., Addington, E. L., Sohl, S. J., Chaoul, A., & Cohen, L. (2017) · Supportive Care in Cancer · doi:10.1007/s00520-016-3556-9 · Cited by 114
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McDonald, P. G., O’Connell, M., & Lutgendorf, S. K. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.01.003 · Cited by 121
Self-citationCalvani, M., Pelon, F., Comito, G., Taddei, M. L., Moretti, S., Innocenti, S., Nassini, R., Gerlini, G., Borgognoni, L., Bambi, F., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2652 · Cited by 109
“Stress delivered catecholamines can reach the tumor mass via circulating blood or via local sympathetic nerve fibers [12, 45, 46].”
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“Regarding the implications of bereavement for cancer risk, stress hormones, especially glucocorticoids, adrenaline, and noradrenaline, have multiple known effects on human tumor biology (114, 115).”
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The stress hormone norepinephrine increases migration of prostate cancer cells in vitro and in vivo
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“These results open a new scenario for the use of β-blockers for chemoprevention of metastasis development in patients with diagnosed cancer, because the diagnosis of cancer itself causes stress and especially in prostate cancer patients that are emotionally involved for the impact of the disease on the quality of life…”
BackgroundOutcomes of cancer surgery after inhalational and intravenous anesthesia: A systematic review
Soltanizadeh, S., Degett, T. H., & Gögenür, I. (2017) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2017.08.001 · Cited by 93
Stress and coping in women with breast cancer:unravelling the mechanisms to improve resilience
Borgi, M., Collacchi, B., Ortona, E., & Cirulli, F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.011 · Cited by 90
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“Furthermore, these proinflammatory cytokines (interleukin (IL)-6 and IL-1β) were associated with the induction of suppressor cell populations that may further inhibit immune responses.(8,9)”
BackgroundTargeting tumor innervation: premises, promises, and challenges
Li, X., Peng, X., Yang, S., Wei, S., Fan, Q., Liu, J., Yang, L., & Li, H. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00930-9 · Cited by 85
Shi, M., Yang, Z., Hu, M., Liu, D., Hu, Y., Qian, L., Zhang, W., Chen, H., Guo, L., Yu, M., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202364 · Cited by 73
“Emotional distress in cancer patients can cause complex physiological and neuroendocrine changes, leading to the activation of the hypothalamic-pituitary-adrenal axis and increased release of stress-related hormones, such as catecholamine (17, 18).”
BackgroundThe immunomodulatory mechanism of dexmedetomidine
Yuki, K. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107709 · Cited by 72
Bouchard, L. C., Antoni, M. H., Blomberg, B. B., Stagl, J. M., Gudenkauf, L. M., Jutagir, D. R., Diaz, A., Lechner, S. C., Glück, S., Derhagopian, R. P., et al. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000261 · Cited by 70
“, depression and depressed mood) and biobehavioral processes such as increased inflammation (7,10,28) via sympathetic nervous system signaling (30).”
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“Adrenergic signaling increases the numbers of monocytes in the circulation(54) and stimulates tumor cells to secrete chemokines (eg, colony stimulating factor 1 [CSF1] and C-C motif chemokine ligand 2 [CCL2]), which attract monocytes to infiltrate the tumor and evolve into macrophages.(58,78) Within this tumor microen…”
BackgroundExposure to road traffic and railway noise and postmenopausal breast cancer: A cohort study
Sørensen, M., Ketzel, M., Overvad, K., Tjønneland, A. M., & Raaschou‐Nielsen, O. (2013) · International Journal of Cancer · doi:10.1002/ijc.28592 · Cited by 64
“Glucocorticoids are involved in a variety of cellular and physical processes that might promote tumor progression including apoptosis, immune response and angiogenesis.(22) Though psychosocial stress has been suspected of affecting breast cancer risk and progression for many years, epidemiological studies have failed…”
BackgroundBehavioral Research in Cancer Prevention and Control
Klein, W. M. P., Bloch, M., Hesse, B. W., McDonald, P. G., Nebeling, L. C., O’Connell, M. E., Riley, W. T., Taplin, S. H., & Tesauro, G. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2013.10.004 · Cited by 62
“Moreover, increasing evidence suggests that interactions among health behaviors and other psychosocial experiences (such as stress, chronic depression, and lack of social support) may be related to cancer progression.(26,27) Health behaviors themselves are intimately linked together by psychological processes such as…”
BackgroundMind-Body Practices in Cancer Care
Chaoul, A., Milbury, K., Sood, A. K., Prinsloo, S., & Cohen, L. G. (2014) · Current Oncology Reports · doi:10.1007/s11912-014-0417-x · Cited by 61
Self-citationHeart Rate Variability in Breast Cancer Survivors After the First Year of Treatments
Caro-Morán, E., Fernández‐Lao, C., Galiano‐Castillo, N., Cantarero‐Villanueva, I., Arroyo‐Morales, M., & Díaz‐Rodríguez, L. (2015) · Biological Research For Nursing · doi:10.1177/1099800414568100 · Cited by 60
Cancer’s got nerve: Schwann cells drive perineural invasion
Azam, S. H., & Pecot, C. V. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86801 · Cited by 51
Lopes‐Júnior, L. C., da Silveira, D. S. C., Olson, K. L., Bomfim, E. D. O., Veronez, L. C., dos Santos, J. C., Alonso, J. B., Nascimento, L. C., Pereira-da-Silva, G., & de Lima, R. A. G. (2019) · Cancer Nursing · doi:10.1097/ncc.0000000000000690 · Cited by 55
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Lipschitz, D. L., Kuhn, R., Kinney, A. Y., Grewen, K., Donaldson, G. W., & Nakamura, Y. (2015) · Integrative Cancer Therapies · doi:10.1177/1534735415580675 · Cited by 47
Pedersen, M., Garne, E., Hansen-Nord, N. S., Hjortebjerg, D., Ketzel, M., Raaschou‐Nielsen, O., Andersen, A. N., & Sørensen, M. (2017) · Environmental Research · doi:10.1016/j.envres.2017.07.031 · Cited by 44
“Traffic noise can also act as a stressor causing hyperactivity of the sympathetic autonomic nervous system resulting in elevated levels of glucocorticoid cortisol, which is involved in a variety of cellular processes such as apoptosis, angiogenesis and immune response (Armaiz-Pena et al., 2013).”
BackgroundNervous system regulation of the cancer genome
Cole, S. W. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.11.008 · Cited by 41
“General results from this literature are reviewed elsewhere in this Special Issue (Armaiz-Pena et al., 2012), but some of these findings can be re-summarized specifically through the lens of gene expression.”
Self-citationMomenzadeh, M., Sehhati, M., & Rabbani, H. (2020) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2020.103570 · Cited by 38
Biobehavioral modulation of the exosome transcriptome in ovarian carcinoma
Lutgendorf, S. K., Thaker, P. H., Arevalo, J. M., Goodheart, M. J., Slavich, G. M., Sood, A. K., & Cole, S. W. (2018) · Cancer · doi:10.1002/cncr.31078 · Cited by 34
“mediated by the central nervous system activate multiple downstream pathways, including the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis.(2,3) Preclinical evidence has demonstrated direct effects of b-adrenergic signal-”
Self-citationState of the Science: Stress, Inflammation, and Cancer
Payne, J. K. (2014) · Oncology nursing forum · doi:10.1188/14.onf.533-540 · Cited by 35
Rodríguez-Rabassa, M., Hernández-Torres, R., Rodríguez, Z., Colón-Echevarria, C. B., Maldonado, L., Tollinchi-Natali, N., Torres-Marrero, E., Mulero, A., Albors, D., Pérez‐Morales, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66628-z · Cited by 33
Abrahão, C. A., Bomfim, E., Lopes-Júnior, L. C., & Pereira-da-Silva, G. (2019) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x19834169 · Cited by 1
“A substantial amount of research has shown that chronic activation of the stress response can lead to increased tumor growth mainly due to the disruption of the delicate balance among the central nervous system, endocrine system, and immune system.(14) Previous literature showed that stressful life events are associat…”
RetractedApproach and avoidance coping: Diurnal cortisol rhythm in prostate cancer survivors
Hoyt, M. A., Marín‐Chollom, A. M., Bower, J. E., Thomas, K. S., Irwin, M. R., & Stanton, A. L. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.007 · Cited by 29
“Few studies have sought to identify the possibility that specific strategies for coping with cancer-related stress can shape neuroendocrine mechanisms (e.g., diurnal cortisol) (e.g., Diaz et al., 2014), which can contribute to adverse cancer outcomes (Armaiz-Pena et al., 2013).”
BackgroundSleep quality and depressive symptoms after prostate cancer: The mechanistic role of cortisol.
Hoyt, M. A., Bower, J. E., Irwin, M. R., Weierich, M. R., & Stanton, A. L. (2016) · Behavioral Neuroscience · doi:10.1037/bne0000107 · Cited by 30
Li, W., & Zhao, Y. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_32_18 · Cited by 29
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“There exists a complex regulatory relationship between brain-body crosstalk and the tumor metabolic microenvironment, which is intricately linked to the fine-tuned regulation by the hypothalamus and SNS [141].”
Stress in Metastatic Breast Cancer: To the Bone and Beyond
Lourenço, C., Conceição, F., Jerónimo, C., Lamghari, M., & Sousa, D. M. (2022) · Cancers · doi:10.3390/cancers14081881 · Cited by 28
Xu, W., Liu, J., Zhang, J., Lu, J., & Guo, J. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189032 · Cited by 27
Noise exposure and the risk of cancer: a comprehensive systematic review
Abbasi, M., Yazdanirad, S., Dehdarirad, H., & Hughes, D. (2022) · Reviews on Environmental Health · doi:10.1515/reveh-2022-0021 · Cited by 26
The Impact of Everyday Stressors on the Immune System and Health
Christian, L. M., & Glaser, R. (2011) · Springer eBooks · doi:10.1007/978-3-642-22272-6_4 · Cited by 25
Aquino-Acevedo, A. N., Knochenhauer, H. E., Castillo-Ocampo, Y., Ortiz-León, M., Rivera-López, Y. A., Morales-López, C., Cruz-Robles, M. E., Hernández-Cordero, E. R., Russell, S., Whitaker, R. S., et al. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100558 · Cited by 25
“The sustained release of stress hormones such as catecholamines (norepinephrine [NE] and epinephrine [Epi]) and cortisol in response to chronic stress are known to modulate immune cell populations, such as T-cells and macrophages in several solid tumors (Armaiz-Pena et al., 2013; Colon-Echevarria et al., 2019).”
BackgroundMeron, G., Tishler, Y., Shaashua, L., Rosenne, E., Levi, B., Melamed, R., Gotlieb, N., Matzner, P., Sorski, L., & Ben‐Eliyahu, S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.11.003 · Cited by 23
Thacher, J. D., Oudin, A., Flanagan, E., Mattisson, K., Albin, M. C., Roswall, N., Pyko, A., Aasvang, G. M., Andersen, Z. J., Borgquist, S., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108108 · Cited by 21
Why stress is BAD for cancer patients
Nagaraja, A. S., Armaiz-Peña, G. N., Lutgendorf, S. K., & Sood, A. K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67887 · Cited by 18
“Recent findings regarding the role of stress hormones in chemore-sistance, metastasis, cancer relapse, and surgical recovery have moved the field forward, but the molecular mechanisms underlying these effects are not fully understood (6, 8).”
Self-citationEudaimonic well‐being and tumor norepinephrine in patients with epithelial ovarian cancer
Davis, L. Z., Slavich, G. M., Thaker, P. H., Goodheart, M. J., Bender, D., Dahmoush, L., Farley, D. M., Markon, K. E., Penedo, F. J., Lubaroff, D. M., et al. (2015) · Cancer · doi:10.1002/cncr.29516 · Cited by 20
“The findings of the current study may suggest a potential benefit for patients with greater eudaimonic well-being, given that beta-adrenergic signaling upregulates multiple pathways involved in tumor progression.(24) For example, we previously reported associations of elevated tumor NE in patients with ovarian cancer…”
BackgroundSelf-citationThe influence of cancer on endocrine, immune, and behavioral stress responses
Pyter, L. M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.09.031 · Cited by 19
“Immunological stress responses are of considerable significance to anti-tumor capabilities and mental comorbidities (Armaiz-Pena et al., 2013; Haroon et al., 2012).”
Does sympathetic nervous system modulate tumor progression? A narrative review of the literature
Stavropoulos, I., Sarantopoulos, A., & Liverezas, A. (2020) · Journal of Drug Assessment · doi:10.1080/21556660.2020.1782414 · Cited by 21
“Indeed, several studies, both in human populations and experimental animal models, have shown a protective effect of neuromodulators inhibiting AS, such as b-adrenergic antagonists, even though there are some controversies, especially regarding non-solid tumors [55,57,58].”
BackgroundA Comprehensive Lifestyle Randomized Clinical Trial: Design and Initial Patient Experience
Arun, B., Austin, T., Babiera, G. V., Basen-Engquist, K. M., Carmack, C. L., Chaoul, A., Cohen, L. G., Connelly, L., Haddad, R., Harrison, C. A., et al. (2016) · Integrative Cancer Therapies · doi:10.1177/1534735416679516 · Cited by 18
“Sustained elevations from these pathways can result in diverse effects such as inflammation, angiogenesis, stimulation of cancer invasion, and even reduced efficacy of chemotherapy drugs.(30-32) The underlying signaling pathways(33) offer opportunities for designing new biobehavioral approaches for disrupting the effe…”
BackgroundSelf-citationHorváthová, Ľ., & Mravec, B. (2016) · Endocrine Regulations · doi:10.1515/enr-2016-0023 · Cited by 19
“…Date | 12/24/16 7:55 AM During the last years, many authors have focused on the elucidation of the role of the nervous system in the regulation of biological pathways involved in the cancer growth and development of metastasis (Mancino et al. 2011; Armaiz-Pena et al. 2013; Magnon et al. 2013).”
BackgroundUdumyan, R., Montgomery, S., Fang, F., Valdimarsdóttir, U. A., Harðardóttir, H., Ekbom, A., Smedby, K. E. E., & Fall, K. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-0710 · Cited by 17
“Tumor staging follows the American Cancer Society classification 6th (until 2010) and 7th (since 2010) editions [stage 1: T1/N0/ M0 or T2a/N0/M0; stage 2: T(2b-3)/N0/M0 or T(1-2)/N1/M0; stage 3A: T(1-2)/N2/M0 or T3/N(1-2)/M0 according to the 6 and T(1-3)/N2/M0 or T3/N1/M0 or T4/N (0-1)/M0 according to the 7 editions;…”
BackgroundCancer and cancer survival modulates brain and behavior in a time-of-day-dependent manner in mice
dos Santos, J. C., Bever, S. R., Sullivan, K. A., & Pyter, L. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-42880-w · Cited by 15
Seiler, A., Sood, A. K., Jenewein, J., & Fagundes, C. P. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.12.013 · Cited by 14
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“For instance, hormone dysregulationsmay determine the efficacy of chemo- or immuno-modulatory therapies likely affecting the tumor microenvironment (Mazzoccoli et al., 2010; ThyagaRajan and Priyanka, 2012; Armaiz-Pena et al., 2013; Goubran et al., 2014).”
BackgroundPsychoneuro-oncology: How chronic stress grows cancer
Tausk, F. (2023) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2023.03.008 · Cited by 15
Davoodvandi, A., Asemi, R., Sharifi, M., Reiter, R. J., Matini, A. H., Mirhashemi, S. M., & Asemi, Z. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230409141957 · Cited by 13
Modelling the effects of perioperative interventions on cancer outcome: lessons from dexmedetomidine
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ß-Adrenoreceptors in Human Cancers
Krabóth, Z., & Kálmán, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043671 · Cited by 14
Circadian rhythms disruption in cancer
Lopes‐Júnior, L. C., & Veronez, L. C. (2021) · Biological Rhythm Research · doi:10.1080/09291016.2021.1951470 · Cited by 15
“glucocorticoids and catecholamines (McDonald et al. 2005, 2013; Antoni et al. 2006; Chrousos 2009; Chandwani et al. 2012; Armaiz-Pena et al. 2013; Abrahão et al. 2019).”
BackgroundGoñi‐Balentziaga, O., Garmendia, L., Labaka, A., Lebeña, A., Beitia, G., Gómez-Lázaro, E., & Vegas, Ó. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112747 · Cited by 14
Mechanisms underlying the effects of stress on tumorigenesis and metastasis (Review)
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“Stress can lead to metastatic invasion and metabolic syndrome by the activation of the HPA axis and SNS, respectively, which are characterized by an increased production of IL-6, TNF-α , llasminogen activator inhibitor-1 and metalloproteinase-2 and -9 (108).”
Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs
Sun, X., Lv, H., Zhao, P., He, J., Cui, Q., Wei, M., Feng, S., & Zhu, Y. (2018) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy055 · Cited by 10
Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression
Pan, Y., Zhou, F., He, C., Hui, L., Huang, T., & Wei, Y. (2017) · BioMed Research International · doi:10.1155/2017/6482842 · Cited by 10
“Moreover, stress-induced autonomic response is associated with increased invasive potential [32, 33].”
BackgroundUnraveling the peripheral nervous System's role in tumor: A Double-edged Sword
Wang, Y.-H., Xuan, Y., Liu, C., Wang, X., & Yu, K. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217451 · Cited by 9
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“[13] Psychosocial causes, depression, stress and antiemotions are contributing factors to BC development;[14] the progression of BC is correlated to stress and chronic depression.[15] Progression of cancer through sympathetic nervous system activation enhanced the production of inflammatory cytokines.”
BackgroundMechanisms of stress-attributed breast cancer incidence and progression
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“Psychological stress and affective responses such as anxiety and depression produce neuroendocrine responses that can impact immune, angiogenic, and inflammatory pathways that contribute to the incidence, progression and control of cancer [28, 29].”
Priyanka, H. P., Pratap, U. P., Nair, R. S., Vasantharekha, R., & ThyagaRajan, S. (2024) · Medical Oncology · doi:10.1007/s12032-024-02322-8 · Cited by 7
“Stress and sympathetic nervous system activation have been suggested to influence cancer progression, including breast cancer [20].”
What Is Behavioural Medicine? Commentary on Definition Proposed by Dekker, Stauder and Penedo
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“The field has expanded to include behaviour in all clinical specialties, from immunology [4] to surgery [5] as well as behaviour in the domain of public health [6].”
BackgroundIntegrative Oncology: The Role of Complementary Medicine in Supportive Cancer Care
Deng, G. E., & Latte-Naor, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-90990-5_10 · Cited by 8
Psychoneuroimmunology of Cancer – Recent Findings and Perspectives
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“The ARIMA models of the variables used in this study are the following: positive mood AR (1) ln; negative mood AR (1) ln; irritation MA (1); mental activity AR (4,1) ln; urinary neopterin MA (2) ln.”
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“We previously reported that among women with ovarian cancer, non‐cancer stressors (assessed by self‐report) in the year pre‐surgery were not related to psychosocial factors assessed around the time of surgery; however, a greater number and severity of stressors at the time of surgery were prospectively associated with…”
BackgroundSelf-citationPrognostic Impacts of Depression and Inflammatory Factors in Pancreatic Cancer Patients
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Inequities in the Impacts of Hurricanes and Other Extreme Weather Events for Cancer Survivors
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“Similarly, stress-related physiologic alterations such as activation of the sympathetic nervous system, dysregulation of the hypothalamicpituitary-adrenal (HPA) axis, inflammation, and cellular immune suppression have all been implicated in carcinogenesis (5, 6).”
BackgroundTemperature Plays an Essential Regulatory Role in the Tumor Immune Microenvironment
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Diversified β-2-adrenergic Receptor Expression and Action in Melanoma Cells
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Chronic stress-related neuroendocrine mediators and ovarian cancer
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Effect of the nervous system on cancer: Analysis of clinical studies
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Stress-induced enhancement of immune function
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Stress reactivity, distress and attachment in newly diagnosed breast cancer patients
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Metadata
- Authors
- Armaiz-Pena, G. N., Cole, S. W., Lutgendorf, S. K., & Sood, A. K.
- Affiliations
- University of California, Los Angeles (US)
- University of Iowa (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Sood, Anil K.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 30
- Pages
- S19-S25
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3467346
- OpenAlex
- W2113048638
- Cited by
- 145
- References
- 72
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 18 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 19 · 2014: 6 · 2013: 7
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 109298, R01CA110793, U54CA151668, CA 110793, CA-104825, R01CA109298, CA140933, R01CA104825, R01CA140933, P50CA083639, P30CA016672)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- neuroendocrine regulation, tumor progression, sympathetic nervous system, tumor growth, cell-mediated immunity, inflammation, tumor angiogenesis, tumor invasion, tumor cell survival
- MeSH terms
- Animals, Humans, Neoplasms, Neovascularization, Pathologic, Neurosecretory Systems, Disease Progression
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