The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Neuroendocrine influences on cancer progression
Open accessAbstract
During the past decade, new studies have continued to shed light on the role of neuroendocrine regulation of downstream physiological and biological pathways relevant to cancer growth and progression. More specifically, our knowledge of the effects of the sympathetic nervous system (SNS) on cancer biology has been greatly expanded by new data demonstrating how the cellular immune response, inflammatory processes, tumor-associated angiogenesis, and tumor cell invasion and survival converge to promote tumor growth. This review will summarize these studies, while synthesizing clinical, cellular and molecular research that has continued to unearth the biological events mediating the interplay between SNS-related processes and cancer progression.
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“and earlier cancer-related mortality [20–22]”
From A randomized controlled trial of a multi-modal palliative care intervention to promote advance care planning and psychological well-being among adults with advanced cancer: study protocol. (2022) · cites this paper as [21]
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Citations
Cites
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733 · cited 1×
“In this review, we will focus on chronic stress conditions that keep the body in a constant state of ‘‘overdrive’’, leading to deleterious downstream effects, deregulating the stress response and negatively affecting many organs systems (McEwen, 1998).”
BackgroundThe pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686 · cited 2×
“Tumor cells must perform these steps while evading immune system surveillance, and the cells that fail in any of these tasks cannot metastasize (Fidler, 2003).”
BackgroundStress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190 · cited 2×
“Besides catecholamines, glucocorticoids are also involved in the stress response and can control many normal physiological activities such as circadian rhythms, immune function and restoration of homeostasis (Glaser and Kiecolt-Glaser, 2005).”
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Self-citationThe influence of bio-behavioural factors on tumour biology: pathways and mechanisms
Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., & Sood, A. K. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1820 · Cited by 981 · cited 6×
“Several studies have shown that the effect of stress hormones on cancer cell proliferation varies according to the specific hormone influences and the tumor type studied (as reviewed in Antoni et al., 2006).”
BackgroundInfluentialSelf-citationNeuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957 · cited 2×
“…disease have shown that tumor incidence and progression can be exacerbated by chronic stressors, mainly through the reduction of type 1 cytokines and T cell and natural killer cell activity resulting in impaired antigen presentation and higher numbers of regulatory T cells (Webster et al., 2002).”
BackgroundThe sympathetic nervous system induces a metastatic switch in primary breast cancer
Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930
Self-citationMaximizing mouse cancer models
Frese, K. K., & Tuveson, D. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2192 · Cited by 728 · cited 1×
“Various approaches have been used to model disease (Frese and Tuveson, 2007).”
MethodMolecular Pathways: Beta-Adrenergic Signaling in Cancer
Cole, S. W., & Sood, A. K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0641 · Cited by 713 · cited 2×
“ADRBs are the key components of the stress signaling pathway, and data now suggest that they also play a major role in protumoral signaling pathways (Cole and Sood, 2012).”
BackgroundSelf-citationEpac proteins: multi-purpose cAMP targets
Bos, J. L. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.10.002 · Cited by 532 · cited 1×
“Furthermore, it has been demonstrated that isoproterenol can promote ovarian cancer cell movement and adhesion via laminin-5 through an Epac1 dependent pathway (Bos, 2006).”
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Sympathetic nervous system regulation of the tumour microenvironment
Cole, S. W., Nagaraja, A. S., Lutgendorf, S. K., Green, P. A., & Sood, A. K. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3978 · Cited by 576
Self-citationExploiting the critical perioperative period to improve long-term cancer outcomes
Horowitz, M., Neeman, E., Sharon, E., & Ben-Eliyahu, S. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.224 · Cited by 487
The impact of psychosocial stress and stress management on immune responses in patients with cancer
Antoni, M. H., & Dhabhar, F. S. (2019) · Cancer · doi:10.1002/cncr.31943 · Cited by 419
“The immune system is a crucial mediator through which stress affects the course of cancer,(2,6) although many immune-independent mechanisms also are critical mediators of cancer-related effects of stress.(7) In the current review, we focus on the effects of stress and stress management (SM) on immune function in relat…”
BackgroundDepression in cancer: The many biobehavioral pathways driving tumor progression
Bortolato, B., Hyphantis, T. N., Valpione, S., Perini, G., Maes, M. H. J., Morris, G., Kubera, M., Köhler, C. A., Fernandes, B. S., Stubbs, B., et al. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.11.004 · Cited by 399
“beta-adrenergic receptors on tumor and stromal cells [34].”
BackgroundInfluentialStress and cancer: mechanisms, significance and future directions
Eckerling, A., Ricon-Becker, I., Sorski, L., Sandbank, E., & Ben-Eliyahu, S. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00395-5 · Cited by 348
Metadata
- Authors
- Armaiz-Pena, G. N., Cole, S. W., Lutgendorf, S. K., & Sood, A. K.
- Affiliations
- University of California, Los Angeles (US)
- University of Iowa (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Sood, Anil K.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 30
- Pages
- S19-S25
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3467346
- OpenAlex
- W2113048638
- Cited by
- 145
- References
- 72
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 18 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 19 · 2014: 6 · 2013: 7
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 109298, R01CA110793, U54CA151668, CA 110793, CA-104825, R01CA109298, CA140933, R01CA104825, R01CA140933, P50CA083639, P30CA016672)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- neuroendocrine regulation, tumor progression, sympathetic nervous system, tumor growth, cell-mediated immunity, inflammation, tumor angiogenesis, tumor invasion, tumor cell survival
- MeSH terms
- Animals, Humans, Neoplasms, Neovascularization, Pathologic, Neurosecretory Systems, Disease Progression
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