Cited by 240Stress Responses and CortisolTryptophan and brain disordersNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.

Greater amygdala activity and dorsomedial prefrontal–amygdala coupling are associated with enhanced inflammatory responses to stress

Open access

Muscatell, Keely A., Dedovic, Katarina, Slavich, George M., Jarcho, Michael R., Breen, Elizabeth C., Bower, Julienne E., Irwin, Michael R., Eisenberger, Naomi I.·2015·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2014.06.201PMC PMC4368432

Open this paper in CoChat — free account

Abstract

Psychological stress is implicated in the etiology of many common chronic diseases and mental health disorders. Recent research suggests that inflammation may be a key biological mediator linking stress and health. Nevertheless, the neurocognitive pathways underlying stress-related increases in inflammatory activity are largely unknown. The present study thus examined associations between neural and inflammatory responses to an acute laboratory-based social stressor. Healthy female participants (n=31) were exposed to a brief episode of stress while they underwent an fMRI scan. Blood samples were taken before and after the stressor, and plasma was assayed for markers of inflammatory activity. Exposure to the stressor was associated with significant increases in feelings of social evaluation and rejection, and with increases in levels of inflammation. Analyses linking the neural and inflammatory data revealed that heightened neural activity in the amygdala in response to the stressor was associated with greater increases in inflammation. Functional connectivity analyses indicated that individuals who showed stronger coupling between the amygdala and the dorsomedial prefrontal cortex (DMPFC) also showed a heightened inflammatory response to the stressor. Interestingly, activity in a different set of neural regions was related to increases in feelings of social rejection. These data show that greater amygdala activity in response to a stressor, as well as tighter coupling between the amygdala and the DMPFC, are associated with greater increases in inflammatory activity. Results from this study begin to identify neural mechanisms that might link stress with increased risk for inflammation-related disorders such as cardiovascular disease and depression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbi.2014.06.201

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Inhibitory effects of Indigofera aspalathoides on 20-methylcholanthrene-induced chemical carcinogenesis in rats
Kumar, S., Karrunakaran, C. M., Rao, M. R. K., & Balasubramanian, M. P. (2011) · Journal of Carcinogenesis · doi:10.4103/1477-3163.75458 · Cited by 35
Retracted
The cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · cited 2×
“Furthermore, a growing body of human research suggests that there is increased functional connectivity between DMPFC and threat-related limbic structures during negative emotional states and among individuals with mood disorders (Etkin et al., 2011).”
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766
Causal Relationship Between Stressful Life Events and the Onset of Major Depression
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,566 · cited 1×
“Psychological stress is implicated in the onset and progression of many common and costly chronic diseases, including cardiovascular disease, chronic pain conditions, and major depressive disorder (Cohen et al., 2007; Kendler et al., 1999; Steptoe and Kivimäki, 2012).”
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
(2010) · The Lancet · doi:10.1016/s0140-6736(09)61717-7 · Cited by 2,546
Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis
Choy, E., & Panayi, G. S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103223441207 · Cited by 2,248
From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · cited 1×
“Indeed, psychological stressors can induce increases in inﬂammation (Slavich and Irwin, 2014; Kiecolt-Glaser et al., 2003; Rohleder, 2014; Steptoe et al., 2007), which might contribute to the development of disease (Capuron and Miller, 2004; Choy and Panayi, 2001; DellaGiola and Hannestad, 2010;…”
Self-citation
Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580

Flagged first, then by citations

Show all 56 references

1 of the 56 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–200 of 240

Sociopolitical stress and acute cardiovascular disease hospitalizations around the 2016 presidential election
Mefford, M. T., Mittleman, M. A., Li, B. H., Qian, L., Reynolds, K., Zhou, H. C., Harrison, T. N., Geller, A. C., Sidney, S., Sloan, R. P., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012096117 · Cited by 27
Therapeutic effect of Thymoquinone on behavioural response to UCMS and neuroinflammation in hippocampus and amygdala in BALB/c mice model
Nazir, S., Farooq, R. K., Nasir, S., Hanif, R., & Javed, A. (2022) · Psychopharmacology · doi:10.1007/s00213-021-06038-9 · Cited by 26
Romantic Breakup Distress, Betrayal and Heartbreak: A Review
Field, T. (2017) · International Journal of Behavioral Research & Psychology · doi:10.19070/2332-3000-1700038 · Cited by 33
Stress and streets: How the network structure of streets is associated with stress-related brain activation
Dimitrov, A., Gu, L., Pandit, L., Veer, I. M., Walter, H., Adli, M., & Knöll, M. (2023) · Journal of Environmental Psychology · doi:10.1016/j.jenvp.2023.102142 · Cited by 27
Chronic Stress-Related Neural Activity Associates With Subclinical Cardiovascular Disease in a Community-Based Cohort: Data From the Washington, D.C. Cardiovascular Health and Needs Assessment
Powell‐Wiley, T. M., Dey, A. K., Rivers, J. P., Chaturvedi, A., Andrews, M. R., Ceasar, J. N., Claudel, S. E., Mitchell, V. M., Ayers, C. R., Tamura, K., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.599341 · Cited by 24
The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment
Toft, H., Neupane, S. P., Bramness, J. G., Tilden, T., Wampold, B. E., & Lien, L. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1677-z · Cited by 25
Emotional Well-Being and Cognitive Function Have Robust Relationship With Physical Frailty in Institutionalized Older Women
Furtado, G. E., Caldo‐Silva, A., Pedrosa, A., Letieri, R. V., Hogervorst, E., Teixeira, A. M., & Ferreira, J. P. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.01568 · Cited by 23
Cortisol awakening response predicts intrinsic functional connectivity of the medial prefrontal cortex in the afternoon of the same day
Wu, J., Zhang, S., Li, W., Qin, S., Yong He, A., Yang, Z., Buchanan, T. W., Liu, C., & Zhang, K. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.08.016 · Cited by 25
Influence of chair-based yoga on salivary anti-microbial proteins, functional fitness, perceived stress and well-being in older women: A pilot randomized controlled trial
Marques, M., Chupel, M. U., Furtado, G. E., Minuzzi, L. G., Rosado, F., Pedrosa, F. M., Ferreira, J. P., & Teixeira, A. M. (2017) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2017.04.008 · Cited by 25
Subtypes of stuttering determined by latent class analysis in two Swiss epidemiological surveys
Ajdacic‐Gross, V., Bechtiger, L., Rodgers, S., Müller, M., Kawohl, W., von Känel, R., Mütsch, M., Wulf Rössler, A., Seifritz, E., Castelao, E., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198450 · Cited by 26
Пос ттравматичний стресовий розлад, метаболічний синдром і вег етативна нервова система
Serhiyenko, V. A., Sehin, V. B., Serhiyenko, L. M., & Serhiyenko, A. A. (2023) · Endokrynologia · doi:10.31793/1680-1466.2023.28-4.377 · Cited by 23
Association between resting-state functional connectivity of amygdala subregions and peripheral pro-inflammation cytokines levels in bipolar disorder
Gong, J., Chen, G., Chen, F., Zhong, S., Chen, P., Zhong, H., Lai, S., Tang, G., Wang, J., Luo, Z., et al. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00636-7 · Cited by 22
Stress- and drug-induced neuroimmune signaling as a therapeutic target for comorbid anxiety and substance use disorders
Smiley, C. E., & Wood, S. K. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108212 · Cited by 24
Associations between amygdala reactivity to social threat, perceived stress and C-reactive protein in breast cancer survivors
Leschak, C. J., Dutcher, J. M., Haltom, K. E. B., Breen, E. C., Bower, J. E., & Eisenberger, N. I. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz103 · Cited by 22
Self-citation
Sickness and the Social Brain: Love in the Time of COVID
Smith, C. J. W., & Bilbo, S. D. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.633664 · Cited by 22
Psychological stress is associated with arterial inflammation in people living with treated HIV infection
Chow, F. C., Mundada, N. S., Abohashem, S., Joie, R. L., Iaccarino, L., Arechiga, V. M., Swaminathan, S., Rabinovici, G. D., Epel, E. S., Tawakol, A. A., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.06.019 · Cited by 21
Innate and adaptive immune system consequences of post-traumatic stress disorder
Lauten, T. H., Natour, T., & Case, A. J. (2024) · Autonomic Neuroscience · doi:10.1016/j.autneu.2024.103159 · Cited by 22
Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis
Fu, C.-F., Li, J., Chen, J.-W., Liang, H., Zhao, W.-R., He, S.-Y., Ma, X., Yang, X., & Wang, H. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1365639 · Cited by 19
Blunted diurnal interleukin-6 rhythm is associated with amygdala emotional hyporeactivity and depression: a modulating role of gene-stressor interactions
Hakamata, Y., Hori, H., Mizukami, S., Izawa, S., Yoshida, F., Moriguchi, Y., Hanakawa, T., Inoue, Y., & Tagaya, H. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1196235 · Cited by 20
Salivary Bioscience, Immunity, and Inflammation
Riis, J. L., Byrne, M., Hernández, L. M., & Robles, T. (2020) · Springer eBooks · doi:10.1007/978-3-030-35784-9_9 · Cited by 13
Decreased functional connectivity in patients with major depressive disorder and a history of childhood traumatization through experiences of abuse
Schirmer, S. T., Beckmann, F., Gruber, H., Schlaaff, K., Scheermann, D., Seidenbecher, S., Metzger, C. D., Tempelmann, C., & Frodl, T. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114098 · Cited by 18
Neural Reactivity to Social Punishment Predicts Future Engagement in Nonsuicidal Self-injury Among Peer-Rejected Adolescents
Pollak, O. H., Kwon, S., Jorgensen, N. A., Lindquist, K. A., Telzer, E. H., & Prinstein, M. J. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.09.030 · Cited by 21
Exploring the links between personality and immune function
Mengelkoch, S., Gassen, J., Corrigan, E. K., & Hill, S. E. (2021) · Personality and Individual Differences · doi:10.1016/j.paid.2021.111179 · Cited by 22
The omnipresence of autonomic modulation in health and disease
Forstenpointner, J., Elman, I., Freeman, R. L., & Borsook, D. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102218 · Cited by 20
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias
Hodges, T. E., Lieblich, S. E., Rechlin, R. K., & Galea, L. A. M. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00299-4 · Cited by 22
Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood
Shin, S. H., & Kim, Y. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_6 · Cited by 19
Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus
Beyer, D. K. E., Mattukat, A., & Freund, N. (2021) · International Journal of Bipolar Disorders · doi:10.1186/s40345-020-00212-2 · Cited by 18
The Stressed Brain: Neural Underpinnings of Social Stress Processing in Humans
Muscatell, K. A., Merritt, C., Cohen, J. R., Chang, L. J., & Lindquist, K. A. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_281 · Cited by 17
Self-citation
Persistent adaptation by chronic alcohol is facilitated by neuroimmune activation linked to stress and CRF
Breese, G. R., & Knapp, D. J. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.01.005 · Cited by 16
On the role of the amygdala for experiencing fatigue in patients with multiple sclerosis
Hanken, K., Francis, Y., Kastrup, A., Eling, P., Klein, J., & Hildebrandt, H. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.12.014 · Cited by 16
Individual differences in resting-state connectivity and giving social support: implications for health
Inagaki, T. K., & Meyer, M. L. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz052 · Cited by 16
Associations between peripheral inflammatory markers and amygdala activity and connectivity in response to emotional faces in adolescents
Swartz, J., Carranza, A. F., Knodt, A., Irwin, M., & Hostinar, C. E. (2022) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2022.06.014 · Cited by 14
Self-citation
Ketogenic Diet and Inflammation: Implications for Mood and Anxiety Disorders
Karkafi, R. E., Gebara, T., Salem, M., Kamel, J., Khoury, G. E., Zalal, M., & Fakhoury, M. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_23 · Cited by 19
A Connectome-Wide Functional Signature of Trait Anger
Kim, M. J., Elliott, M. L., Knodt, A. R., & Hariri, A. R. (2021) · Clinical Psychological Science · doi:10.1177/21677026211030240 · Cited by 14
Chronic physical exercise alleviates stress-associated amygdala metabolic activity in obese women: A prospective serial 18F-FDG PET/CT study
Pahk, K., Joung, C., Kwon, H. W., & Kim, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1046838 · Cited by 13
Heightened neural activity and functional connectivity responses to social rejection in female adolescents at risk for depression: Testing the Social Signal Transduction Theory of Depression
Shields, G. S., Vinograd, M., Bui, T., Sichko, S., Irwin, M. R., & Slavich, G. M. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.10.113 · Cited by 13
Self-citation
mRNA and microRNA Profiles in the Amygdala Are Relevant to Susceptibility and Resilience to Psychological Stress Induced in Mice
Sun, J., Lu, Y., Yang, J., Song, Z., Lu, W., & Wang, J. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01570-3 · Cited by 12
Associations Between Statin Use and Negative Affective Bias During COVID-19: An Observational, Longitudinal UK Study Investigating Depression Vulnerability
Gillespie, A. L., Wigg, C., Assche, I. A. V., Murphy, S. E., & Harmer, C. J. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.03.009 · Cited by 13
Association between inflammatory markers (SII and SIRI) and anxiety levels in Parkinson’s disease
Zhou, W., Zeng, T.-F., Liu, D., Pang, R., & Gong, L. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1635817 · Cited by 11
A Model of Our Contemplative Nature
Kaufman, J. A. (2015) · Ecopsychology · doi:10.1089/eco.2015.0014 · Cited by 13
Stress und Gesundheit
Werdecker, L., & Esch, T. (2019) · Springer Reference Pflege, Therapie, Gesundheit · doi:10.1007/978-3-662-58314-2_33 · Cited by 16
Towards a multidimensional model of inflamed depression
Wijaya, M. T., Jin, R. R., Liu, X., Zhang, R., & Lee, T. M. C. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100564 · Cited by 12
Behavioral interventions in health neuroscience
Dutcher, J. M., & Creswell, J. D. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13913 · Cited by 12
The antidepressant effect of cognitive reappraisal training on individuals cognitively vulnerable to depression: Could cognitive bias be modified through the prefrontal–amygdala circuits?
Wang, X., He, Y., & Feng, Z. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.919002 · Cited by 13
C-reactive protein is related to a distinct set of alterations in resting-state functional connectivity contributing to a differential pathophysiology of major depressive disorder
Beckmann, F., Seidenbecher, S., Metzger, C. D., Gescher, D. M., Carballedo, A., Tozzi, L., O’Keane, V., & Frodl, T. (2022) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2022.111440 · Cited by 10
Association of stress-related neural activity and baseline interleukin-6 plasma levels in healthy adults
Voges, J. F., Müller‐Pinzler, L., Neis, M., Luebber, F., Lange, T., Hundt, J. E., Kasten, M., Krämer, U. M., Krach, S., & Rademacher, L. (2022) · Stress · doi:10.1080/10253890.2022.2094704 · Cited by 8
Neuroanatomy of Sepsis-Associated Encephalopathy
Heming, N., Mazeraud, A., & Verdonk, F. (2017) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-319-51908-1_25 · Cited by 9
Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation
Sichko, S., Bui, T. Q., Vinograd, M., Shields, G. S., Saha, K., Devkota, S., Alvarez, H. A. O., Carroll, J., Cole, S. W., Irwin, M. R., et al. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100334 · Cited by 9
Self-citation
Acupuncture at Zusanli (ST36) for the benefits of sepsis–laboratory evidence for “preventive treatment of disease” and “holistic concept” in the protective effects of acupuncture: a literature review of rodent studies
Zeng, L., & Yan, J. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1645906 · Cited by 8
Inflammation as a mediator of stress-related psychiatric disorders
Flux, M. C., & Lowry, C. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00052-6 · Cited by 10
Daytime Light Deficiency Leads to Sex- and Brain Region-Specific Neuroinflammatory Responses in a Diurnal Rodent
Costello, A., Linning‐Duffy, K., Vandenbrook, C., Lonstein, J. S., & Yan, L. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01256-x · Cited by 7
Stress, mindfulness, and systemic lupus erythematosus: An overview and directions for future research
Molina, E., Gould, N. F., Lee, K., Krimins, R. A., Hardenbergh, D., & Timlin, H. (2022) · Lupus · doi:10.1177/09612033221122980 · Cited by 8
Specific alterations of resting‐state functional connectivity in the triple network related to comorbid anxiety in major depressive disorder
Beckmann, F., Gruber, H., Seidenbecher, S., Schirmer, S. T., Metzger, C. D., Tozzi, L., & Frodl, T. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16249 · Cited by 8
Pathomechanistic Synergy Between Particulate Matter and Traffic Noise-Induced Cardiovascular Damage and the Classical Risk Factor Hypertension
Kuntić, M., Hahad, O., Al-Kindi, S. G., Oelze, M. W., Lelieveld, J., Daiber, A., & Münzel, T. F. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0659 · Cited by 10
Preliminary insights into associations between C-reactive protein and social network dynamics
Kornienko, O., Riis, J. L., Davila, M., White, N. S., & Garner, P. W. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105690 · Cited by 8
Subjective social status and neural processing of race in Mexican American adolescents
Muscatell, K. A., McCormick, E. M., & Telzer, E. H. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000949 · Cited by 9
Self-citation
Is PTSD an Evolutionary Survival Adaptation Initiated by Unrestrained Cytokine Signaling and Maintained by Epigenetic Change?
Rudzki, S. J. (2022) · Military Medicine · doi:10.1093/milmed/usac095 · Cited by 8
Cannabis and Complex Posttraumatic Stress Disorder
Dagan, Y., & Yager, J. (2020) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001172 · Cited by 7
MRI based neuroanatomical segmentation in breast cancer patients: leptomeningeal carcinomatosis vs. oligometastatic brain disease vs. multimetastastic brain disease
Mayinger, M. C., Reibelt, A., Borm, K. J., Ettl, J., Wilkens, J. J., Combs, S. E., Oechsner, M., & Duma, M. N. (2019) · Radiation Oncology · doi:10.1186/s13014-019-1380-3 · Cited by 7
An earlier time of scan is associated with greater threat-related amygdala reactivity
Baranger, D. A. A., Margolis, S., Hariri, A. R., & Bogdan, R. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx057 · Cited by 8
Neurobiological Mechanisms Link Bipolar Disorder to Cardiovascular Disease: A Retrospective Biobank Study of Adverse Event Risk and Contributory Mechanisms
Baek, J. H., Grewal, S., Karam, K. A., Hanlon, E. R., Abohashem, S., Seligowski, A. V., Henry, M., Osborne, M. T., Nierenberg, A. A., & Tawakol, A. A. (2025) · Bipolar Disorders · doi:10.1111/bdi.13516 · Cited by 6
Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna, M., Somerville, Y., Saporta, N., Nathansohn-Levi, B., Shelly, S., Edry, L., Zagoory‐Sharon, O., Feldman, R., & Amedi, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-91457-3 · Cited by 9
Associations between the neural-hematopoietic-inflammatory axis and DNA methylation of stress-related genes in human leukocytes: Data from the Washington, D.C. cardiovascular health and needs assessment
Cintron, M., Baumer, Y., Pang, A. P. S., Peterson, E. M. A., Ortiz-Whittingham, L. R., Jacobs, J. A., Sharda, S., Potharaju, K. A., Baez, A. S., Gutierrez‐Huerta, C. A., et al. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.100976 · Cited by 7
Prefrontal tDCS Attenuates Self-Referential Attentional Deployment: A Mechanism Underlying Adaptive Emotional Reactivity to Social-Evaluative Threat
Allaert, J., Erdogan, M., Sánchez-López, Á., Baeken, C., Raedt, R. D., & Vanderhasselt, M. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.700557 · Cited by 7
The Inflammatory Hypothesis of Depression: Implications for Diagnosis and Practice
Hall, S. B., Jones, L. K., Tyson, L., Woods, K., & Keltz, A. (2016) · Journal of Mental Health Counseling · doi:10.17744/mehc.38.2.04 · Cited by 6
From the Self to the Social Regulation of Emotion: An Evolving Psychological and Neural Model
Ochsner, K. N. (2019) · Nebraska Symposium on Motivation/The Nebraska symposium on motivation · doi:10.1007/978-3-030-27473-3_3 · Cited by 6
Is there a place for cellular therapy in depression?
do Prado‐Lima, P. A. S., Costa‐Ferro, Z. S. M., Souza, B. S. D. F., da Cruz, I. B. M., & Lab, B. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i9.553 · Cited by 6
Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions
Alhazzaa, O. A., Abahussin, H. M., Majrashi, M. A., Alotaibi, M. S., Alkhrayef, M. N., Alhamdan, Z. A., & Alawad, A. O. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1743142 · Cited by 5
Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis
He, R., Wu, J., Han, L., Li, M., Guo, W., Fu, J., Mei, B., Gross, E. R., Liu, X., & Lu, Y. (2025) · Advanced Science · doi:10.1002/advs.202504406 · Cited by 5
Pharmacological Strategies for Suicide Prevention Based on the Social Pain Model: A Scoping Review
Rajkumar, R. P. (2022) · Psych · doi:10.3390/psych4030038 · Cited by 5
Interplay Between the Physical Environment and the Human Brain: A Review of MRI Research
Beyer, M., Sudimac, S., Steininger, M. O., & Kühn, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-64699-7_3 · Cited by 8
Antinociceptive fatty acid patterns differ in children with psychosomatic recurrent abdominal pain and healthy controls
Alfvén, G., & Strandvik, B. (2016) · Acta Paediatrica · doi:10.1111/apa.13381 · Cited by 5
Heart-brain axis pathophysiological understanding and clinical impact
Vancheri, F., Vancheri, S., Longo, G., Vancheri, E., & Henein, M. Y. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1681715 · Cited by 4
Protective effect of exercise on animals with sepsis: a systematic review of the existing literature
Yang, N., Jiang, N., Shen, C., Gao, M., Tong, Q., & Sun, J. L. (2025) · BMC Infectious Diseases · doi:10.1186/s12879-025-10557-7 · Cited by 4
Affective Reactions as Mediators of the Relationship Between Stigma and Health
Mendes, W. B., & Muscatell, K. A. (2017) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190243470.013.10 · Cited by 4
Self-citation
Structural and Functional Brain Alterations in Populations with Familial Risk for Depression: A Narrative Review
Burhanoğlu, B. B., & Gönül, A. S. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000350 · Cited by 5
Association between chronic stress-related amygdala metabolic activity and lymph node metastasis in endometrial cancer
Ryu, K.-J., Kim, S., Joung, C., Lee, S., Park, H., Song, J. Y., Pahk, K. J., & Pahk, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-79987-8 · Cited by 3
The effects of forced exercise and zinc supplementation during pregnancy on prenatally stress‐induced behavioral and neurobiological consequences in adolescent female rat offspring
Sameei, P., Fatehfar, S., Abdollahzadeh, N., Chodari, L., Saboory, E., & Roshan‐Milani, S. (2023) · Developmental Psychobiology · doi:10.1002/dev.22411 · Cited by 3
Stress-related genetic factors modify the effect of socioeconomic status on cardiovascular risk
Karam, K. A., Abohashem, S., Lau, H. C., Civieri, G., Aldosoky, W., Khalil, M., Arora, G. S., Rollings, R. C., Assefa, A., Ahmad, T. Z., et al. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02130-2 · Cited by 3
The Role of Long Non-Coding RNA in Anxiety Disorders: A Literature Review
López-Rocha, L. D., Ruíz-Hernández, A., Martínez-Coronilla, G., Leija-Montoya, A. G., Peña-Peña, M., Sánchez‐Muñoz, F., Campoy, U. R., & González-Ramírez, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115042 · Cited by 4
The Resting Brain Sets Support-Giving in Motion: Dorsomedial Prefrontal Cortex Activity During Momentary Rest Primes Supportive Responding
Inagaki, T. K., Brietzke, S. C., & Meyer, M. L. (2020) · Cerebral Cortex Communications · doi:10.1093/texcom/tgaa081 · Cited by 3
Neural and peripheral markers of reward during positive social evaluation are associated with less clinician-rated depression symptom severity in adolescence
Gray, Z. J., Shields, G. S., Sichko, S., Bui, T. Q., Vinograd, M., Alvarez, H. A. O., & Slavich, G. M. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2022.100149 · Cited by 3
Self-citation
Neural‐hematopoietic‐inflammatory axis in nonsmokers, electronic cigarette users, and tobacco smokers
Ruedisueli, I., Arastoo, S., Gupta, P. K., GORNBEIN, J. A., & Middlekauff, H. R. (2022) · Physiological Reports · doi:10.14814/phy2.15412 · Cited by 3
Neighborhood Perceptions Are Associated With Intrinsic Amygdala Activity and Resting-State Connectivity With Salience Network Nodes Among Older Adults
Ortiz-Whittingham, L. R., Zhan, L., Ortiz-Chaparro, E. N., Baumer, Y., Zenk, S. N., Lamar, M., & Powell‐Wiley, T. M. (2023) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001272 · Cited by 3
Temporal dynamics of inflammatory, platelet, and neurotrophic markers during social stress in relation to suicidal ideation and suicide attempt history
Lengvenytė, A., Olié, É., Cognasse, F., Hamzeh‐Cognasse, H., Alacreu‐Crespo, A., & Courtet, P. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.100984 · Cited by 3
A pilot investigation of the impact of acute mental and physical fatigue exposure on inflammatory cytokines and state fatigue level in breast cancer survivors
Weinstein, A. A., Seth, K., Gordy, S., Jabbar, K., Noori, N., Birerdinc, A., Baranova, A. V., Winter, P. M., & Gerber, L. H. (2025) · BMC Women s Health · doi:10.1186/s12905-025-03758-4 · Cited by 2
Stress, Immune System and the Brain
Bourgognon, J.-M., McColl, A., Suessmilch, M., Krishnadas, R., & Cavanagh, J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108539623.004 · Cited by 2
Stress und Gesundheit
Werdecker, L., & Esch, T. (2018) · Springer Reference Pflege, Therapie, Gesundheit · doi:10.1007/978-3-662-54179-1_33-1 · Cited by 3
MEDICINE AND PSYCHOLOGY: MODERN PROBLEMS, NEW TECHNOLOGIES AND WAYS OF DEVELOPING OUTDATED THEORIES
Vladlenov, D., Mezhiievska, I. A., Maslovskyi, V., Pavlov, S. V., Razmadze, M., Samkharadze, R., Gachechiladze, L., Razmadze, D., Тащук, В. К., Khrebtii, H. I., et al. (2024) · Іnternational Science Group eBooks · doi:10.46299/isg.2024.mono.med.1 · Cited by 2
Do inflammation and relational motivation coordinate having better sex? The interplay between C-reactive protein and relational approach motivation on sexual well-being
Jolink, T. A., Way, B. M., Younge, A. N., & Algoe, S. B. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.054 · Cited by 2
Galactooligosaccharides Attenuate Behavioural, Haematological and Immunological Abnormalities and Influence Gut Microbiota in Rats with Amygdala Hyperactivation Induced by Electrical Stimulation
Ruciński, J., Kurowska, E., Myślińska, D., Grembecka, B., Piekarczyk, N., Necel, A., Kosznik-Kwaśnicka, K., & Majkutewicz, I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094353 · Cited by 4
C-reactive protein is associated with pain-type somatic symptoms independent of mental health symptoms in adolescents: Evidence from the ALSPAC study
Cooney-Quane, J., Thomas, D. S., Nolan, Y. M., & Dockray, S. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101082 · Cited by 2
Neurocognitive and Physiological Mechanisms Linking Stress and Health
Muscatell, K. A., & Eisenberger, N. I. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00148-2 · Cited by 2
Self-citation
Advances of the risk factors, immune and inflammation, therapy in postpartum post-traumatic stress disorder
Yang, B., Li, Z., Xu, X., & Miao, Z. (2024) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2024.100086 · Cited by 1
Chronic Stress May Amplify Gender/Sex Differences in Amygdala Reactivity to Ambiguous Emotional Stimuli
Lorenz, T. K., Harp, N. R., Pierce, J. E., Angeletti, P. C., & Neta, M. (2025) · Stress and Health · doi:10.1002/smi.70035 · Cited by 1
Pharmacological Activity of Scopoletin: Deciphering the Potential of Coumarins in Cognitive Dysfunction
Wal, P., Vadera, S., Aziz, N., Gupta, P., Rajesh, K. S., Rao, C. M. P., & Sharma, M. C. (2025) · Current Drug Research Reviews · doi:10.2174/0125899775358899250726213130 · Cited by 1
Immunomodulatory Potential of Escitalopram on C‐C Motif Chemokine Ligand 5 and Fibroblast Growth Factor 2 in Patients With Generalised Anxiety Disorder
Suresh, S., Gupta, R., Srivastava, S., Halder, S., & Garg, S. (2025) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.70023 · Cited by 1
Disrupted Prefrontal Regulation of Social Rejection in Irritable Bowel Syndrome
Xiong, N., Mi, Q., Sun, Q., Liu, Q., & Fan, T. (2026) · Psychotherapy and Psychosomatics · doi:10.1159/000551116 · Cited by 1
Early life stress-induced depression reveals distinct region-specific modulation of unfolded protein response genes in the prefrontal cortex and hippocampus of rats
Griffin, A. K., Roy, B., & Dwivedi, Y. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1747106 · Cited by 1
The Maternal Brain in Context: Systemic Physiological Changes Across Pregnancy
Grotzinger, H., Martínez‐Garcia, M., Miller, E. C., Stelzer, I. A., Collado, M. C., & Jacobs, E. G. (2026) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102124-043515 · Cited by 1

Authors: Muscatell, K. A., Dedovic, K., Slavich, G. M., Jarcho, M. R., Breen, E. C., Bower, J. E., Irwin, M. R., & Eisenberger, N. I.
Affiliations: University of California, Los Angeles (US)
Loras College (US)
Corresponding author: Eisenberger, Naomi I.
ORCID: Muscatell, Keely A.
Slavich, George M.
Jarcho, Michael R.
Breen, Elizabeth C.
Bower, Julienne E.
Irwin, Michael R.
Eisenberger, Naomi I.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2015-01
Volume: 43
Pages: 46-53
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2014.06.201
PMC: PMC4368432
OpenAlex: W1968731032
Cited by: 240
References: 56
Citations by year: 2026: 18 · 2025: 24 · 2024: 12 · 2023: 12 · 2022: 45 · 2021: 19 · 2020: 21 · 2019: 22 · 2018: 18 · 2017: 20 · 2016: 18 · 2015: 9
FWCI: 8.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Funders: National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award (NIE)
UCLA Cousins Center for Psychoneuroimmunology Seed Grant (NIE)
UCLA Clinical & Translational Science Institute (CTSI) Seed Grant (NIE)
NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI (UL1TR000124)
NIA/NIH (AG028748)
Canadian Institutes of Health Research Post-Doctoral Research Fellowship (KD)
National Science Foundation Graduate Research Fellowship (KAM)
NIH Pre-Doctoral Institutional Training Grant (MH015750)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: psychological stress, inflammation, amygdala, dorsomedial prefrontal cortex, social stress, social rejection, social evaluation, plasma inflammatory markers, cardiovascular disease, depression
MeSH terms: Adolescent, Amygdala, Emotions, Female, Humans, Inflammation, Magnetic Resonance Imaging, Neural Pathways, Stress, Psychological, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Prefrontal Cortex, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Greater amygdala activity and dorsomedial prefrontal–amygdala coupling are associated with enhanced inflammatory responses to stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks