Cited by 615Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsTreatment of Major Depression

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Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue

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Enache, Daniela, Pariante, Carmine M., Mondelli, Valeria·2019·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2019.06.015

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Abstract

BACKGROUND Increased peripheral inflammation has been consistently reported in patients with major depressive disorder (MDD). However, only few studies have explored markers of central (brain) inflammation in patients with MDD. The aim of this study is to systematically review in vivo and post-mortem markers of central inflammation, including studies examining cerebrospinal fluid (CSF), positron emission tomography, and post-mortem brain tissues in subjects suffering with MDD compared with controls. METHODS PubMed and Medline databases were searched up to December 2018. We included studies measuring cerebrospinal fluid (CSF) cytokines and chemokines, positron emission tomography (PET) studies; and post-mortem studies measuring cytokines, chemokines and cell-specific markers of microglia and astrocytes, all in MDD. A meta-analysis was performed only for CSF and PET studies, as studies on post-mortem markers of inflammation had different cell-specific markers and analysed different brain regions. RESULTS A total of 69 studies met the inclusion criteria. CSF levels of IL-6 and TNF-α were higher in patients with MDD compared with controls (standardised mean difference SMD 0.37, 95%CI: 0.17-0.57 and SMD 0.58, 95%CI 0.26-0.90, respectively). CSF levels of IL-6 were increased in suicide attempters regardless of their psychiatric diagnosis. Translocator protein, a PET marker of central inflammation, was elevated in the anterior cingulate cortex and temporal cortex of patients with MDD compared with controls (SMD 0.78, 95%CI: 0.41-1.16 and SMD 0.52, 95%CI: 0.19-0.85 respectively). Abnormalities in CSF and PET inflammatory markers were not correlated with those in peripheral blood. In post-mortem studies, two studies found increased markers of microglia in MDD brains, while four studies found no MDD related changes. Of the studies investigating expression of cell-specific marker for astrocytes, thirteen studies reported a decreased expression of astrocytes specific markers, two studies reported increased expression of astrocytes specific markers, and eleven studies did not detect any difference. Four out of six studies reported decreased markers of oligodendrocytes in the prefrontal cortex. Post-mortem brain levels of tumor necrosis alpha (TNF-α) were also found increased in MDD. CONCLUSIONS Our review suggests the presence of an increase in IL-6 and TNF-alpha levels in CSF and brain parenchyma, in the context of a possible increased microglia activity and reduction of astrocytes and oligodendrocytes markers in MDD. The reduced number of astrocytes may lead to compromised integrity of blood brain barrier with increased monocyte recruitment and infiltration, which is partly supported by post-mortem studies and by PET studies showing an increased TSPO expression in MDD.

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Authors: Enache, D., Pariante, C. M., & Mondelli, V.
Affiliations: King's College London (GB)
National Health Service (GB)
Corresponding author: Mondelli, Valeria
ORCID: Enache, Daniela
Pariante, Carmine M.
Mondelli, Valeria
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2019-10
Volume: 81
Pages: 24-40
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2019.06.015
OpenAlex: W2953025937
Semantic Scholar: 83e5363ffd00c2dba7a412e43a5a292f085d67ed
Cited by: 615
References: 97
Citations by year: 2026: 54 · 2025: 74 · 2024: 160 · 2023: 91 · 2022: 86 · 2021: 87 · 2020: 52 · 2019: 11
FWCI: 3.71
Type: journal article
Language: en
Open access: green
kclpure.kcl.ac.uk
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
Funders: GlaxoSmithKline foundation
South London and Maudsley NHS Foundation Trust
Kingâs College London
Svenska LÃ¤karesÃ¤llskapet (MQBF1)
National Institute for Health Research
Medical Research Foundation (MRF-160-0005)
H. Lundbeck A/S
Wellcome Trust
Medical Research Council
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: major depressive disorder, neuroinflammation, cerebrospinal fluid cytokines, interleukin-6, TNF-α, translocator protein (TSPO), positron emission tomography, microglia, astrocytes, oligodendrocytes, suicide attempters, postmortem brain, peripheral inflammation, prefrontal cortex, anterior cingulate cortex
MeSH terms: Astrocytes, Autopsy, Brain, Major Depressive Disorder, Female, Humans, Inflammation, Male, Oligodendroglia, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Cytokines, Prefrontal Cortex, Microglia, Receptors, GABA, Chemokines, Positron-Emission Tomography

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Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue

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