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Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue
Open accessAbstract
BACKGROUND Increased peripheral inflammation has been consistently reported in patients with major depressive disorder (MDD). However, only few studies have explored markers of central (brain) inflammation in patients with MDD. The aim of this study is to systematically review in vivo and post-mortem markers of central inflammation, including studies examining cerebrospinal fluid (CSF), positron emission tomography, and post-mortem brain tissues in subjects suffering with MDD compared with controls. METHODS PubMed and Medline databases were searched up to December 2018. We included studies measuring cerebrospinal fluid (CSF) cytokines and chemokines, positron emission tomography (PET) studies; and post-mortem studies measuring cytokines, chemokines and cell-specific markers of microglia and astrocytes, all in MDD. A meta-analysis was performed only for CSF and PET studies, as studies on post-mortem markers of inflammation had different cell-specific markers and analysed different brain regions. RESULTS A total of 69 studies met the inclusion criteria. CSF levels of IL-6 and TNF-α were higher in patients with MDD compared with controls (standardised mean difference SMD 0.37, 95%CI: 0.17-0.57 and SMD 0.58, 95%CI 0.26-0.90, respectively). CSF levels of IL-6 were increased in suicide attempters regardless of their psychiatric diagnosis. Translocator protein, a PET marker of central inflammation, was elevated in the anterior cingulate cortex and temporal cortex of patients with MDD compared with controls (SMD 0.78, 95%CI: 0.41-1.16 and SMD 0.52, 95%CI: 0.19-0.85 respectively). Abnormalities in CSF and PET inflammatory markers were not correlated with those in peripheral blood. In post-mortem studies, two studies found increased markers of microglia in MDD brains, while four studies found no MDD related changes. Of the studies investigating expression of cell-specific marker for astrocytes, thirteen studies reported a decreased expression of astrocytes specific markers, two studies reported increased expression of astrocytes specific markers, and eleven studies did not detect any difference. Four out of six studies reported decreased markers of oligodendrocytes in the prefrontal cortex. Post-mortem brain levels of tumor necrosis alpha (TNF-α) were also found increased in MDD. CONCLUSIONS Our review suggests the presence of an increase in IL-6 and TNF-alpha levels in CSF and brain parenchyma, in the context of a possible increased microglia activity and reduction of astrocytes and oligodendrocytes markers in MDD. The reduced number of astrocytes may lead to compromised integrity of blood brain barrier with increased monocyte recruitment and infiltration, which is partly supported by post-mortem studies and by PET studies showing an increased TSPO expression in MDD.
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Estimating the mean and variance from the median, range, and the size of a sample
Hozo, S. P., Djulbegovic, B., & Hozo, I. (2005) · BMC Medical Research Methodology · doi:10.1186/1471-2288-5-13 · Cited by 9,062
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · cited 1×
“Astrocytes play a key role in maintaining the neurotransmitters homeostasis (glutamate and GABA), water transport homeostasis, ion homeostasis, metabolic support, synaptogenesis and synaptic plasticity, maintaining the integrity of the blood brain barrier (Verkhratsky and Nedergaard, 2018).”
BackgroundInflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · cited 1×
“Cytokines administration has been shown to induce activation of the hypothalamic–pituitary–adrenal (HPA) axis and peripheral glucocorticoid secretion (Felger and Lotrich, 2013).”
BackgroundSetiawan, E., Wilson, A. A., Mizrahi, R., Rusjan, P. M., Miler, L., Rajkowska, G., Suridjan, I., Kennedy, J. L., Rekkas, P. V., Houle, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2427 · Cited by 939 · cited 2×
“Seven studies found no correlation between markers of central inflammation (CSF cytokines or PET TSPO) and peripheral inflammation (Bay-Richter et al., 2015; Hannestad et al., 2013; Holmes et al., 2018; Isung et al., 2012; Lindqvist et al., 2009; Sasayama et al., 2013; Setiawan et al., 2015).”
BackgroundPanic, N., Leoncini, E., de Belvis, G., Ricciardi, W., & Boccia, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083138 · Cited by 883 · cited 1×
“This study followed the PRISMA guidelines for conducting and reporting systematic reviews (Panic et al., 2013).”
MethodSteiner, J., Bielau, H., Brisch, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.-G., & Bogerts, B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.013 · Cited by 791
Inflammation-associated depression: From serotonin to kynurenine
Dantzer, R., O’Connor, J. C., Lawson, M. A., & Kelley, K. W. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.012 · Cited by 726 · cited 3×
“23 The concomitant activation of microglia and reduced function of astrocytes could also have downstream effects on the kynurenine pathway (Dantzer et al., 2011).”
BackgroundInfluentialUranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659
Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue
Rajkowska, G., & Stockmeier, C. (2013) · Current Drug Targets · doi:10.2174/13894501113149990156 · Cited by 603 · cited 14×
“CSF levels of IL-6 and TNF-α were higher in patients with MDD compared with controls (standardised mean difference SMD 0.37, 95%CI: 0.17-0.57 and SMD 0.58, 95%CI 0.26-0.90, respectively).”
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Xie, X., Lai, W., Xu, S., Forti, M. D., Zhang, J., Chen, M., Yao, L., Wang, P., Hao, K., & Rong, H. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.12.014 · Cited by 62
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Nusslock, R., Alloy, L. B., Brody, G. H., & Miller, G. E. (2024) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13961 · Cited by 67
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Tziolos, N., Ιωάννου, Π., Baliou, S., & Kofteridis, D. P. (2023) · Microorganisms · doi:10.3390/microorganisms11102458 · Cited by 56
Li, T., Li, Y., Chen, J., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.07.015 · Cited by 57
Su, W., Li, J.-M., Zhang, T., Cao, Z., Hu, T., Zhong, S.-Y., Xu, Z.-Y., Gong, H., & Jiang, C. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110796 · Cited by 57
Liu, S., Du, Y., Chen, L., & Cheng, Y. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02672-8 · Cited by 55
An integrated cytokine and kynurenine network as the basis of neuroimmune communication
Stone, T. W., Clanchy, F. I. L., Huang, Y., Chiang, N., Darlington, L. G., & Williams, R. O. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1002004 · Cited by 57
Henderson, T. A., van Lierop, M. J., McLean, M., Uszler, J. M., Thornton, J. F., Siow, Y.-H., Pavel, D. G., Cardaci, J., & Cohen, P. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00276 · Cited by 55
Nettis, M. A., Veronese, M., Nikkheslat, N., Mariani, N., Lombardo, G., Sforzini, L., Enache, D., Harrison, N. A., Turkheimer, F., Mondelli, V., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0768-z · Cited by 51
Self-citationAronica, R., Enrico, P., Squarcina, L., Brambilla, P., & Delvecchio, G. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104922 · Cited by 56
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Sethi, S., & Ford, J. M. (2022) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20220009 · Cited by 54
Murri, M. B., Folesani, F., Zerbinati, L., Nanni, M. G., Ounalli, H., Caruso, R., & Grassi, L. G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17155545 · Cited by 58
De Giorgi, R., De Crescenzo, F., Rizzo Pesci, N., Martens, M., Howard, W., Cowen, P. J., & Harmer, C. J. (2021) · PLOS ONE · doi:10.1371/journal.pone.0249409 · Cited by 52
Chen, S., Miao, H., Jiang, X., Sun, P., Fan, Q., & Huang, W. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120916 · Cited by 52
Ishikawa, Y., Kitaoka, S., Kawano, Y., Ishii, S., Suzuki, T., Wakahashi, K., KATO, T., Katayama, Y., & Furuyashiki, T. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15203 · Cited by 50
Dattilo, V., Amato, R., Perrotti, N., & Gennarelli, M. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00826 · Cited by 49
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Cai, Z., Ye, T., Xu, X., Gao, M., Zhang, Y.-R., Wang, D., Gu, Y., Zhu, H., Tong, L., Lu, J., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109931 · Cited by 43
Yi, S., Zou, J., Meng, L., Chen, H.-M., Hong, Z.-Q., Liu, X., Farooq, U., Chen, M.-X., Lin, Z., Zhou, W., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.864481 · Cited by 44
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Rebai, R., Jasmin, L., & Boudah, A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111246 · Cited by 40
Gonzales, M. M., Samra, J. K., O’Donnell, A., Mackin, R. S., Salinas, J., Jacob, M. E., Satizábal, C. L., Aparicio, H. J., Thibault, E. G., Sanchez, J. S., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210232 · Cited by 39
Choi, K. W., Jang, E. H., Kim, A. Y., Kim, H., Park, M. J., Byun, S., D, M. F. M., Mischoulon, D., Papakostas, G. I., Yu, H. Y., et al. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.12.011 · Cited by 35
Druzhkova, T. A., Yakovlev, A. A., Rider, F. K., Zinchuk, M., Guekht, A. B., & Gulyaeva, N. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810414 · Cited by 41
Caccavale, S., Tancredi, V., Boccellino, M. P., Babino, G., Fulgione, E., & Argenziano, G. (2023) · Life · doi:10.3390/life13010189 · Cited by 39
Xu, S., Xie, X., Yao, L., Wang, W. J., Zhang, H., Chen, M., Sun, S., Nie, Z., Nagy, C., & Liu, Z. (2023) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13596 · Cited by 42
Eid, R. S., Lieblich, S. E., Duarte‐Guterman, P., Chaiton, J. A., Mah, A., Wong, S. J., Wen, Y., & Galea, L. A. M. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104651 · Cited by 34
Liu, L., Dai, L., Xu, D., Wang, Y., Bai, L., Chen, X., Li, M., Yang, S., & Tang, Y. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.05.014 · Cited by 37
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Dabboussi, N., Debs, E., Bouji, M., Rafei, R., & Farès, N. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111056 · Cited by 38
Cosma, N. C., Üsekes, B., Otto, L. R., Gerike, S., Heuser, I., Regen, F., & Hellmann‐Regen, J. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.02.009 · Cited by 37
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Kuring, J. K., Mathias, J. L., Ward, L., & Tachas, G. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.10.009 · Cited by 39
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Cheng, J., Chen, M., Zhu, J., Li, C., Zhang, Q., Geng, D., Liu, Q., & Yi, L. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.06.025 · Cited by 33
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Sublette, M. E., Daray, F. M., Ganança, L., & Shaikh, S. R. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02322-6 · Cited by 35
Omori, W., Hattori, K., Kajitani, N., Okada‐Tsuchioka, M., Boku, S., Kunugi, H., Okamoto, Y., & Takebayashi, M. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa049 · Cited by 32
Picker, L. D., & Haarman, B. C. M. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05308-0 · Cited by 31
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Róg, J., Wingralek, Z. J., Nowak, K., Grudzień, M., Grunwald, A., Banaszek, A., & Karakuła‐Juchnowicz, H. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102819 · Cited by 31
Daray, F. M., Grendas, L. N., Arena, Á. R., Tifner, V., Casiani, R. I. Á., Olaviaga, A., Chiapella, L. C., Vázquez, G. H., Penna, M. B., Hunter, F., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02902-2 · Cited by 32
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Shao, X., Wang, Y., Geng, Z., Liang, G., Zhu, X., Liu, L., Meng, M., Duan, L., & Zhu, G. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03126-0 · Cited by 32
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Islam, S., Islam, T., Nahar, Z., Shahriar, M., Islam, S. M. A., Bhuiyan, M. A., & Islam, M. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276619 · Cited by 31
González Ibáñez, F., Halvorson, T., Sharma, K., McKee, C. G., Carrier, M., Picard, K., Vernoux, N., Bisht, K., Deslauriers, J., Lalowski, M., et al. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2023.09.006 · Cited by 28
Zhang, G., Li, L., Kong, Y., Xu, D., Bao, Y., Zhang, Z., Liao, Z., Jiao, J., Fan, D., Long, X., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.02.049 · Cited by 30
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Liu, N., Yan, W., Su, R., Zhang, L., Wang, X., Li, Z., Qin, D., & Peng, J. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.992223 · Cited by 33
Adams, C., Perry, N., Conigrave, J. H., Hurzeler, T. P., Stevens, J., Dunbar, K. P. Y., Sweeney, A., Lee, K. S., Sutherland, G. T., Haber, P., et al. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14992 · Cited by 28
Sørensen, N. V., Borbye‐Lorenzen, N., Christensen, R. H. B., Orlovska‐Waast, S., Jeppesen, R., Skogstrand, K., & Benros, M. E. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02757-2 · Cited by 25
Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder
Ye, J., Duan, C., Han, J., Chen, J., Sun, N., Li, Y., Yuan, T., & Peng, D. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01878 · Cited by 30
Lin, Y., Wang, H.-L., Lu, K., Huang, Y., Panyod, S., Liu, W.-T., Yang, S., Chen, M.-H., Lu, Y., & Sheen, L. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113395 · Cited by 26
Forbes, M., O'Neil, A. E., Lane, M. M., Agustini, B., Myles, N., & Berk, M. (2021) · Drugs & Aging · doi:10.1007/s40266-021-00858-2 · Cited by 25
The immune phenotype of perinatal anxiety
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Hasan, A. R., Tasnim, F., Aktaruzzaman, M., Islam, M. T., Rayhan, R., Brishti, A., Hur, J., Porter, J. E., & Raihan, M. O. (2024) · Neuroglia · doi:10.3390/neuroglia5040027 · Cited by 25
Pawley, L. C., Hueston, C. M., O’Leary, J. D., Kozareva, D. A., Cryan, J. F., O’Leary, O. F., & Nolan, Y. M. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.10.007 · Cited by 28
Zhou, Y., Wang, C., Lan, X., Zheng, W., Li, H., Chao, Z., Wu, K., McIntyre, R. S., & Ning, Y. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.10.037 · Cited by 25
Inflammatory markers and depression in Parkinson’s disease: a systematic review
Ramanzini, L. G., Camargo, L. F. M., Silveira, J. O. F., & Bochi, G. V. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06363-7 · Cited by 25
Reisinger, S. N., Sideromenos, S., Horváth, O., Derdak, S. V., Cicvaric, A., Monje, F. J., Bilban, M., Häring, M., Glat, M. J., & Pollak, D. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00904-2 · Cited by 23
Kong, Y., He, G., Zhang, X., & Li, J. (2021) · Brain Sciences · doi:10.3390/brainsci11111514 · Cited by 24
Mechanisms of paeoniaceae action as an antidepressant
Guo, W., Yao, X.-X., Cui, R., Yang, W., & Wang, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.934199 · Cited by 27
Pang, F., Yang, Y., Huang, S., Yang, Z., Zhu, Z., Liao, D., Guo, X., Zhou, M., Li, Y., & Tang, C. (2023) · Brain Sciences · doi:10.3390/brainsci13030436 · Cited by 25
Goodkin, K., Evering, T. H., Anderson, A. M. L., Ragin, A. B., Monaco, C. L., Gavegnano, C., Avery, R. J., Rourke, S. B., Cysique, L. A., & Brew, B. J. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1130938 · Cited by 26
Fonseca, C., Ettcheto, M., Bicker, J., Fernandes, M. J., Falcão, A. C., Camins, A., & Fortuna, A. C. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101998 · Cited by 31
Sha, Q., Fu, Z., Galvis, M. L. E., Madaj, Z. B., Underwood, M. D., Steiner, J. A., Dwork, A. J., Simpson, N. R., Galfalvy, H., Rozoklija, G., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02311-9 · Cited by 25
Sun, S., Liu, Q., Wang, Z., Huang, Y.-Y., Sublette, M. E., Dwork, A. J., Rosoklija, G. B., Ge, Y., Galfalvy, H., Mann, J. J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02420-z · Cited by 24
Li, K., Wang, K., Xu, S., Xie, X., Tang, Y., Zhang, L., & Liu, Z. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s477482 · Cited by 23
Metadata
- Authors
- Enache, D., Pariante, C. M., & Mondelli, V.
- Affiliations
- King's College London (GB)
- National Health Service (GB)
- Corresponding author
- Mondelli, Valeria
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 81
- Pages
- 24-40
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2953025937
- Semantic Scholar
- 83e5363ffd00c2dba7a412e43a5a292f085d67ed
- Cited by
- 615
- References
- 97
- Citations by year
- 2026: 54 · 2025: 74 · 2024: 160 · 2023: 91 · 2022: 86 · 2021: 87 · 2020: 52 · 2019: 11
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- Funders
- GlaxoSmithKline foundation
- South London and Maudsley NHS Foundation Trust
- Kingâs College London
- Svenska Läkaresällskapet (MQBF1)
- National Institute for Health Research
- Medical Research Foundation (MRF-160-0005)
- H. Lundbeck A/S
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- major depressive disorder, neuroinflammation, cerebrospinal fluid cytokines, interleukin-6, TNF-α, translocator protein (TSPO), positron emission tomography, microglia, astrocytes, oligodendrocytes, suicide attempters, postmortem brain, peripheral inflammation, prefrontal cortex, anterior cingulate cortex
- MeSH terms
- Astrocytes, Autopsy, Brain, Major Depressive Disorder, Female, Humans, Inflammation, Male, Oligodendroglia, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Cytokines, Prefrontal Cortex, Microglia, Receptors, GABA, Chemokines, Positron-Emission Tomography
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