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The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

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Cooke, Kenneth R., Luznik, Leo, Sarantopoulos, Stefanie, Hakim, Frances T., Jagasia, Madan, Fowler, Daniel H., van den Brink, Marcel R.M., Hansen, John A., Parkman, Robertson, Miklos, David B., Martin, Paul J., Paczesny, Sophie, Vogelsang, Georgia, Pavletic, Steven, Ritz, Jerome, Schultz, Kirk R., Blazar, Bruce R.·2017·Biology of Blood and Marrow Transplantation

DOI 10.1016/j.bbmt.2016.09.023

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Abstract

Chronic graft-versus-host disease Blood and marrow transplantation Immune mechanisms Clinical manifestationsA B S T R A C T Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality and disability in allogeneic hematopoietic cell transplantation recipients and a major obstacle to improving outcomes.The biology of chronic GVHD remains enigmatic, but understanding the underpinnings of the immunologic mechanisms responsible for the initiation and progression of disease is fundamental to developing effective prevention and treatment strategies.The goals of this task force review are as follows:• Summarize the current state of the science regarding pathogenic mechanisms of chronic GVHD and crit- ical knowledge gaps.• Develop working hypotheses/overriding concepts for chronic GVHD development.• Define the usefulness of current preclinical models to test working hypotheses and ultimately discover and develop new therapeutic strategies.• Identify shortcomings of preclinical models, and define criteria for the creation of additional models to address these limitations.

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Teshima, T. (2004) · CRC Press eBooks · doi:10.1201/b14165-2 · Cited by 16
Tolerance Associated Gene Expression following Allogeneic Hematopoietic Cell Transplantation
Pidala, J., Bloom, G. C., Eschrich, S. A., Sarwal, M., Enkemann, S., Betts, B. C., Beato, F., Yoder, S., & Anasetti, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117001 · Cited by 14
What we know and mostly do not know about bronchiolitis obliterans syndrome
Martin, P. J., & Chien, J. W. (2012) · Bone Marrow Transplantation · doi:10.1038/bmt.2011.38 · Cited by 13
Self-citation
Biomarkers to Discern Transplantation Tolerance after Allogeneic Hematopoietic Cell Transplantation
Pidala, J., Bloom, G. C., Enkemann, S. A., Eschrich, S. A., Lancaster, J. M., & Anasetti, C. (2009) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2009.11.009 · Cited by 9
Inhibition of cathepsin S reduces allogeneic T cell priming but not graft-versus-host disease against minor histocompatibility antigens.
Fujii, H., Ivison, S., Shimizu, H., Kajiwara, R., Kariminia, A., Yan, M., Dutz, J., & Schultz, K. (2012) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2011.11.027 · Cited by 7
Self-citation

ROCK2, a critical regulator of immune modulation and fibrosis has emerged as a therapeutic target in chronic graft-versus-host disease
Zanin-Zhorov, A., & Blazar, B. R. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108823 · Cited by 74
Self-citation
Chronic graft-versus-host disease. Part I: Epidemiology, pathogenesis, and clinical manifestations
Baumrin, E., Loren, A. W., Falk, S. J., Mays, J. W., & Cowen, E. W. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2022.12.024 · Cited by 59
Retracted

See all 472

Authors: Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., Martin, P. J., Paczesny, S., Vogelsang, G., Pavletic, S., Ritz, J., Schultz, K. R., & Blazar, B. R.
Venue: Biology of Blood and Marrow Transplantation
Publisher: Elsevier BV
Published: 2017-02
Volume: 23
Issue: 2
Pages: 211-234
ISSN: 1083-8791 (ISSN-L)
DOI: 10.1016/j.bbmt.2016.09.023
OpenAlex: W2528448343
Cited by: 472
References: 274
FWCI: 28.70
Type: journal article
Language: en
Open access: hybrid

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

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