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The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease
Open accessAbstract
Chronic graft-versus-host disease Blood and marrow transplantation Immune mechanisms Clinical manifestationsA B S T R A C T Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality and disability in allogeneic hematopoietic cell transplantation recipients and a major obstacle to improving outcomes.The biology of chronic GVHD remains enigmatic, but understanding the underpinnings of the immunologic mechanisms responsible for the initiation and progression of disease is fundamental to developing effective prevention and treatment strategies.The goals of this task force review are as follows:• Summarize the current state of the science regarding pathogenic mechanisms of chronic GVHD and crit- ical knowledge gaps.• Develop working hypotheses/overriding concepts for chronic GVHD development.• Define the usefulness of current preclinical models to test working hypotheses and ultimately discover and develop new therapeutic strategies.• Identify shortcomings of preclinical models, and define criteria for the creation of additional models to address these limitations.
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Retracted
Metadata
- Authors
- Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., Martin, P. J., Paczesny, S., Vogelsang, G., Pavletic, S., Ritz, J., Schultz, K. R., & Blazar, B. R.
- Venue
- Biology of Blood and Marrow Transplantation
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 23
- Issue
- 2
- Pages
- 211-234
- ISSN
- 1083-8791 (ISSN-L)
- OpenAlex
- W2528448343
- Cited by
- 472
- References
- 274
- FWCI
- 28.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.