The effects of hippocampal system lesions on a novel temporal discrimination task for rats
Abstract
A novel, appetitive, Pavlovian conditioning task was used to assess interval timing. Experiment 1 showed that normal rats could discriminate between tones of 1.5s and 0.5s duration, or between tones of 12.0 s and 3.0 s duration. Learning was demonstrated by a greater duration of magazine responding in the period before the delivery of a food reward and after cessation of the CS+ compared to the same time period after cessation of the CS-. Learning was, however, asymmetric as it was much quicker when the CS+ was the longer of the two durations (1.5s and 12.0 s, respectively). Experiment 2 assessed the impact of fornix lesions on the acquisition of one version of this task (CS+ 1.5s, CS- 0.5s). No evidence was found of a change in discrimination learning following surgery. Experiment 3 examined whether rats with either fornix or hippocampal lesions affected discriminations between 12.0 s and 3.0 s stimuli. Again, there was no evidence of a lesion-induced deficit. T-maze alternation training confirmed the effectiveness of these lesions. The results not only reveal that neither the fornix nor the hippocampus is necessary for distinguishing temporal intervals within the ranges tested but also showed how under some circumstances these lesions can leave trace conditioning intact.
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Animals can behaviorally respond at certain intervals (seconds to minutes) according to a programmed stimulus.
“Studies in training animals with classical and operant conditioning have shown that animals can behaviorally respond at certain intervals (seconds to minutes) according to the programmed stimulus (Kirsch et al., 2004; Kyd et al., 2008)”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Kyd et al., 2008
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- Authors
- Kyd, R. J., Pearce, J. M., Haselgrove, M., Amin, E., & Aggleton, J. P.
- Affiliations
- University of Cambridge (GB)
- Cardiff University (GB)
- University of Nottingham (GB)
- Corresponding author
- Aggleton, J.P.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 187
- Issue
- 1
- Pages
- 159-171
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2108962518
- Cited by
- 32
- References
- 66
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- interval timing, temporal discrimination, hippocampus, fornix, hippocampal lesions, fornix lesions, classical conditioning, trace conditioning, appetitive conditioning, T-maze alternation, rats
- MeSH terms
- Analysis of Variance, Animals, Attention, Conditioning, Classical, Discrimination, Psychological, Discrimination Learning, Hippocampus, Male, Psychomotor Performance, Time Perception, Fornix, Brain, Rats
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