Lesion of the ventral and intermediate hippocampus abolishes anticipatory activity in the medial prefrontal cortex of the rat

Burton, Brian G.; Hok, Vincent; Save, Etienne; Poucet, Bruno

doi:10.1016/j.bbr.2008.11.045

Cited by 86Memory and Neural MechanismsNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Lesion of the ventral and intermediate hippocampus abolishes anticipatory activity in the medial prefrontal cortex of the rat

Burton, Brian G., Hok, Vincent, Save, Etienne, Poucet, Bruno·2009·Behavioural Brain Research

DOI 10.1016/j.bbr.2008.11.045

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Abstract

The medial prefrontal cortex (mPFC) of the rat receives a prominent input from the ventral two thirds of the hippocampus, a structure important for spatial awareness, working memory and motivation. We recently found [Hok V, Lenck-Santini PP, Roux S, Save E, Muller RU, Poucet B. Goal-related activity in hippocampal place cells. J Neurosci 2007;27:472-82.] that neurones in the dorsal hippocampus exhibit anticipatory firing prior to the release of a food pellet on an operant task. Here we look for similar activity in the mPFC on the same task and test whether this activity is dependent on the hippocampus. Rats were trained to navigate to a goal zone, wait for the release of a food pellet and then forage for the pellet while unit activity was recorded in the prelimbic and infralimbic areas of the mPFC. Two 16 min sessions were conducted per day, one session with the goal delimited by a cue disc, the second without the cue. In controls, a large proportion of mPFC neurones exhibited activity similar to that seen in the hippocampus while the animal was stationary at the goal. Over half exhibited the same activity regardless of goal location. Anticipatory activity was largely abolished in animals with bilateral lesions of the ventral and intermediate hippocampus, both in cued and uncued sessions. Even though lesioned animals continued to perform the task, they tended to leave the goal zone prematurely. We suggest that the anticipatory activity in the mPFC is dependent on similar activity in the hippocampus and that both structures have a role in either impulse control or reward expectation.

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Lesions in the ventral hippocampus disrupted PFC activity for anticipating a spatial goal.
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From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Burton et al., 2009
The hippocampus processes and guides the PFC with respect to spatial information.
“indicating that the hippocampus processes and guides the PFC with respect to spatial information”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Burton et al., 2009

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Abstracts of Posters
(2001) · Brain and Cognition · doi:10.1006/brcg.2000.1274
Hippocampal-midbrain circuit enhances the pleasure of anticipation in the prefrontal cortex
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Cognitive control of behavior and hippocampal information processing without medial prefrontal cortexPreprint
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Neurons in rat medial prefrontal cortex show anticipatory rate changes to predictable differential rewards in a spatial memory task
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Authors: Burton, B. G., Hok, V., Save, E., & Poucet, B.
Affiliations: Aix-Marseille Université (FR)
Corresponding author: Poucet, Bruno
ORCID: Hok, Vincent
Poucet, Bruno
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2009-05
Volume: 199
Issue: 2
Pages: 222-234
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2008.11.045
OpenAlex: W2028824531
Cited by: 86
References: 92
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 8 · 2020: 2 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 9 · 2012: 3
FWCI: 1.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
HAL AMU (submittedVersion)
Funders: Fondation pour la Recherche Médicale (FDT-2006-1208711)
Fondation Fyssen
Agence Nationale de la Recherche
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: medial prefrontal cortex, hippocampus, anticipatory activity, hippocampal lesions, prelimbic cortex, infralimbic cortex, goal-directed behavior, reward anticipation, impulse control, spatial navigation
MeSH terms: Action Potentials, Animals, Cues, Hippocampus, Male, Reward, Spatial Behavior, Time Factors, Prefrontal Cortex, Rats, Long-Evans, Rats

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Lesion of the ventral and intermediate hippocampus abolishes anticipatory activity in the medial prefrontal cortex of the rat

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