Molecular biology of 5-HT receptors

High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Kühn, P., Weis, W. I., Kobilka, B. K., et al. (2007) · Science · doi:10.1126/science.1150577 · Cited by 3,280

A review of central 5-HT receptors and their function

Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,211

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 3,025

Molecular, pharmacological and functional diversity of 5-HT receptors

Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,898

Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol

Peroutka, S. J., & Snyder, S. H. (1979) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13812-1 · Cited by 1,363

GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function

Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Yao, X.-J., Weis, W. I., Stevens, R. C., et al. (2007) · Science · doi:10.1126/science.1150609 · Cited by 1,335

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

Tecott, L. H., Sun, L. M., Akana, S. F., Strack, A. M., Lowenstein, D. H., Dallman, M. F., & Julius, D. J. (1995) · Nature · doi:10.1038/374542a0 · Cited by 1,275

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

Bradley, P. B., Engel, G., Feniuk, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., & Saxena, P. R. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90207-8 · Cited by 1,259

Regulation of serotonin-2C receptor G-protein coupling by RNA editing

Burns, C. M., Chu, H., Rueter, S. M., Hutchinson, L. K., Canton, H., Sanders-Bush, E., & Emeson, R. B. (1997) · Nature · doi:10.1038/387303a0 · Cited by 1,010

Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel

Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R., & Julius, D. J. (1991) · Science · doi:10.1126/science.1718042 · Cited by 978

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906

TWO KINDS OF TRYPTAMINE RECEPTOR

Gaddum, J. H., & Picarelli, Z. P. (1957) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1957.tb00142.x · Cited by 851

Enhanced Aggressive Behavior in Mice Lacking 5-HT 1B Receptor

Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Ségu, L., Buhot, M.-C., & Hen, R. (1994) · Science · doi:10.1126/science.8091214 · Cited by 839

Serotonin receptor 1A knockout: An animal model of anxiety-related disorder

Ramboz, S., Oosting, R. S., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M. M., Mann, J. J., Brunner, D., & Hen, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14476 · Cited by 831

Elevated anxiety and antidepressant-like responses in serotonin 5-HT 1A receptor mutant mice

Heisler, L. K., Chu, H.-M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., & Tecott, L. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15049 · Cited by 704

A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

Lovenberg, T. W., Baron, B. M., de Lecea, L., Miller, J. D., Prosser, R. A., Rea, M. A., Foye, P. E., Racke, M. M., Slone, A. L., Siegel, B. W., et al. (1993) · Neuron · doi:10.1016/0896-6273(93)90149-l · Cited by 691

Increased anxiety of mice lacking the serotonin 1A receptor

Parks, C. L., Robinson, P. S., Sibille, E. L., Shenk, T. E., & Tóth, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10734 · Cited by 691

Serotoninergic regulation of emotional and behavioural control processes

Cools, R., Roberts, A. C., & Robbins, T. W. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.10.011 · Cited by 656

Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

Ruat, M., Traiffort, É., Leurs, R., Tardivel‐Lacombe, J., Díaz, J., Arrang, J., & Schwartz, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8547 · Cited by 630

Discrimination of Multiple [3H]5‐Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain

Pedigo, N. W., Yamamura, H. I., & Nelson, D. L. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb02397.x · Cited by 627

The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor

Fargin, A., Raymond, J. R., Lohse, M. J., Kobilka, B. K., Caron, M. G., & Lefkowitz, R. J. (1988) · Nature · doi:10.1038/335358a0 · Cited by 597

The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site

Pazos, Á., Hoyer, D., & Palacios, J. M. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90057-8 · Cited by 596

The 5-HT3B subunit is a major determinant of serotonin-receptor function

Davies, P. A., Pistis, M., Hanna, M. C., Peters, J. A., Lambert, J. J., Hales, T. G., & Kirkness, E. F. (1999) · Nature · doi:10.1038/16941 · Cited by 561

A proposed new nomenclature for 5-HT receptors

Humphrey, P. P. A., Hartig, P. R., & Hoyer, D. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90016-d · Cited by 553

Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.

Bard, J., Zgombick, J. M., Adham, N., VAYSSE, P. J. ‐., Branchek, T. A., & Weinshank, R. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49479-9 · Cited by 533

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

Kobilka, B. K., Frielle, T., Collins, S., Yang-Feng, T. L., Kobilka, T. S., Francke, U., Lefkowitz, R. J., & Caron, M. G. (1987) · Nature · doi:10.1038/329075a0 · Cited by 515

Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

Shen, Y., Monsma, F. J., Metcalf, M. A., José, P. A., Hamblin, M. W., & Sibley, D. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46830-x · Cited by 508

Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene.

Albert, P. R., Zhou, Q., Tol, H. H. M. V., Bunzow, J. R., & Civelli, O. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39437-2 · Cited by 450

A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system.

Dumuis, A., Bouhelal, R., Sebben, M., Cory, R. N., & Bockaert, J. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10130-2 · Cited by 450

Possible Role of Valvular Serotonin 5-HT2B Receptors in the Cardiopathy Associated with Fenfluramine

Fitzgerald, L. W., Burn, T. C., Brown, B. S., Patterson, J. P., Corjay, M. H., Valentine, P. A., Sun, J., Link, J. R., Abbaszade, I. G., Hollis, J. M., et al. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26444-0 · Cited by 440

Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

Launay, J., Hervé, P., Peoc’h, K., Tournois, C., Callebert, J., Nebigil, C. G., Étienne-Selloum, N., Drouet, L. O., Humbert, M. J. C., Simonneau, G., et al. (2002) · Nature Medicine · doi:10.1038/nm764 · Cited by 433

5-HT Receptor Classification and Nomenclature: Towards a Harmonization with the Human Genome

Hoyer, D., & Martin, G. B. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00036-1 · Cited by 415

Structure and functional expression of cloned rat serotonin 5HT‐2 receptor.

Pritchett, D. B., Bach, A. W., Wozny, M., Taleb, O., Toso, R. D., Shih, J. C., & Seeburg, P. H. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03308.x · Cited by 385

Serotonin 2B receptor is required for heart development

Nebigil, C. G., Choi, D., Dierich, A., Hickel, P., LeMeur, M., Messaddeq, N., Launay, J., & Maroteaux, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.17.9508 · Cited by 382

Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT6 Serotonin Receptor

Kohen, R., Metcalf, M. A., Khan, N. A., Druck, T., Huebner, K., Lachowicz, J. E., Meltzer, H. Y., Sibley, D. R., Roth, B. L., & Hamblin, M. W. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66010047.x · Cited by 377

The 5-HT3Receptor Is Present in Different Subpopulations of GABAergic Neurons in the Rat Telencephalon

Morales, M., & Bloom, F. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03157.1997 · Cited by 364

RNA Editing of the Human Serotonin 5-Hydroxytryptamine 2C Receptor Silences Constitutive Activity

Niswender, C. M., Copeland, S. C., Herrick‐Davis, K., Emeson, R. B., & Sanders‐Bush, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9472 · Cited by 364

The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches?

Roth, B., Lopez, E., Patel, S., & Kroeze, W. (2000) · The Neuroscientist · doi:10.1177/107385840000600408 · Cited by 363

Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain

Hoyer, D., & Middlemiss, D. N. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90159-4 · Cited by 352

Hippocampal long-term depression: master or minion in declarative memory processes?

Kemp, A., & Manahan-Vaughan, D. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.01.002 · Cited by 336

The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors

Bonhaus, D. W., Bach, C., DeSouza, A., Salazar, F. H., Matsuoka, B. D., Zuppan, P., Chan, H. W., & Eglen, R. M. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb14977.x · Cited by 306

Receptors for 5-Hydroxytryptamine: Current perspectives on classification and nomenclature

Martin, G. R., & Humphrey, P. P. A. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90058-2 · Cited by 305

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.

Weinshank, R. L., Zgombick, J. M., Macchi, M., Branchek, T. A., & Hartig, P. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3630 · Cited by 294

Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.

Adham, N., Kao, H., Schechter, L. E., Bard, J., Olsen, M. A., Urquhart, D. A., Durkin, M. M., Hartig, P. R., Weinshank, R. L., & Branchek, T. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.408 · Cited by 289

The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.

Julius, D. J., Huang, K. N., Livelli, T. J., Axel, R., & Jessell, T. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.928 · Cited by 284

The Pharmacological and Functional Characteristics of the Serotonin 5-HT3A Receptor Are Specifically Modified by a 5-HT3B Receptor Subunit

Dubin, A. E., Huvar, R., D’Andrea, M. R., Pyati, J., Zhu, J. Y., Joy, K. C., Wilson, S. J., Galindo, J. E., Glass, C. A., Luo, L., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30799 · Cited by 281

Alignment of receptor nomenclature with the human genome: classification of 5-HT1B and 5-HT1D receptor subtypes

Hartig, P. R., Hoyer, D., Humphrey, P. P. A., & Martin, G. R. (1996) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(96)30002-3 · Cited by 280

Effector Coupling Mechanisms of the Cloned 5-HT1A Receptor

Fargin, A., Raymond, J. R., Regan, J. W., Cotecchia, S., Lefkowitz, R. J., & Caron, M. G. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63778-0 · Cited by 272

A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover.

Conn, P. J., Sanders‐Bush, E., Hoffman, B. J., & Hartig, P. R. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4086 · Cited by 268

The 5‐HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.

Gerald, C., Adham, N., Kao, H., Olsen, M. A., Laz, T. M., Schechter, L. E., Bard, J., VAYSSE, P. J. ‐., Hartig, P. R., & Branchek, T. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07280.x · Cited by 260

Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E

Niesler, B., Frank, B., Kapeller, J., & Rappold, G. (2003) · Gene · doi:10.1016/s0378-1119(03)00503-1 · Cited by 252

Insights into the Neurobiology of Impulsive Behavior from Serotonin Receptor Knockout Mice

Brunner, D., & Hen, R. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52356.x · Cited by 240

Molecular pharmacology and biology of 5-HT1C receptors

Hoyer, D. (1988) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(88)90174-5 · Cited by 236

A subfamily of 5-HT1D receptor genes

Hartig, P. R., Branchek, T. A., & Weinshank, R. L. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90053-9 · Cited by 230

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression

Guscott, M. R., Bristow, L. J., Hadingham, K. L., Rosahl, T. W., Beer, M. S., Stanton, J. A., Bromidge, F. A., Owens, A. P., Huscroft, I. T., Myers, J., et al. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.11.015 · Cited by 229

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

Hamblin, M. W., & Metcalf, M. A. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12918-0 · Cited by 229

Characterization and distribution of putative 5‐ht7receptors in guinea‐pig brain

To, Z. P., Bonhaus, D. W., Eglen, R. M., & Jakeman, L. B. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16327.x · Cited by 225

Four 5‐Hydroxytryptamine7 (5‐HT7) Receptor Isoforms in Human and Rat Produced by Alternative Splicing: Species Differences Due to Altered Intron‐Exon Organization

Heidmann, D., Metcalf, M. A., Kohen, R., & Hamblin, M. W. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68041372.x · Cited by 221

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine

Arranz, M. J., Munro, J., Owen, M. J., Spurlock, G., Sham, P. C., Zhao, J., Kirov, G., Collier, D. A., & Kerwin, R. W. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000348 · Cited by 220

Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers.

Maroteaux, L., Saudou, F., Amlaiky, N., Boschert, U., Plassat, J., & Hen, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.3020 · Cited by 219

Molecular cloning and characterization of a rat brain cDNA encoding a 5‐hydroxytryptamine1B receptor.

Voigt, M. M., Laurie, D. J., SEEBURG, P. H., & Bach, A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04977.x · Cited by 218

Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization.

Matthes, H. W. D., Boschert, U., Amlaiky, N., Grailhe, R., Plassat, J., Muscatelli, F., Mattéi, M., & Hen, R. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13615-8 · Cited by 210

A 5‐hydroxytryptamine receptor in human atrium

Kaumann, A. J., Sanders, L., Brown, A. M., Murray, K. J., & Brown, M. J. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14108.x · Cited by 204

Pharmacological characterization of 5-hydroxytryptamine4(5-HT4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: effect of substituted benzamide derivatives.

Bockaert, J., Sebben, M., & Dumuis, A. (1990) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10829-8 · Cited by 202

5-HT1 receptor knock out — behavioral consequences

Ramboz, S., Saudou, F., Amara, D. A., Belzung, C., Ségu, L., Misslin, R., Buhot, M.-C., & Hen, R. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00119-2 · Cited by 197

Novel Brain-Specific 5-HT4 Receptor Splice Variants Show Marked Constitutive Activity: Role of the C-Terminal Intracellular Domain

Claeysen, S., Sebben, M., Bécamel, C., Bockaert, J., & Dumuis, A. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23188-6 · Cited by 197

Cloning and functional characterization of the rat stomach fundus serotonin receptor.

Foguet, M., Hoyer, D., Pardo, L. A., Parekh, A. B., Kluxen, F. W., Kalkman, H. O., Stühmer, W., & Lübbert, H. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05427.x · Cited by 195

Molecular cloning, functional expression, and pharmacological characterization of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus.

Kursar, J. D., Nelson, D. L., Wainscott, D. B., Cohen, M. L., & Baez, M. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08969-2 · Cited by 186

Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain.

Erlander, M., Lovenberg, T. W., Baron, B. M., de Lecea, L., Danielson, P. E., Racke, M. M., Slone, A. L., Siegel, B. W., Foye, P. E., & Cannon, K. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3452 · Cited by 184

Serotonin 5‐HT2C Receptor RNA Editing Alters Receptor Basal Activity

Herrick‐Davis, K., Grinde, E., & Niswender, C. M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.731711.x · Cited by 182

5-HT1A receptor knockout mouse as a genetic model of anxiety

Tóth, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01280-9 · Cited by 177

Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT 4 Receptor Knock-Out Mice

Compan, V., Zhou, M., Grailhe, R., Gazzara, R. A., Martin, R., Gingrich, J. A., Dumuis, A., Brunner, D., Bockaert, J., & Hen, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2806-03.2004 · Cited by 177

Characterization of the human 5-hydroxytryptamine1B receptor.

Jin, H., Oksenberg, D., Ashkenazi, A., Peroutka, S. J., Duncan, A., Rozmahel, R. F., Yang, Y., Mengod, G., Palacios, J. M., & O’Dowd, B. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42612-9 · Cited by 175

Differential Composition of 5-Hydroxytryptamine3Receptors Synthesized in the Rat CNS and Peripheral Nervous System

Morales, M., & Wang, S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06732.2002 · Cited by 175

Contribution of 5-HT2Receptor Subtypes to Sleep–Wakefulness and Respiratory Control, and Functional Adaptations in Knock-Out Mice Lacking 5-HT2AReceptors

Popa, D., Léna, C., Fabre, V., Prenat, C., Gingrich, J. A., Escourrou, P., Hamon, M., & Adrien, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1724-05.2005 · Cited by 175

Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT1B receptor gene in 273 nuclear families from a multi-centre sample

Hawi, Z., Dring, M., Kirley, A., Foley, D., Kent, L., Craddock, N., Asherson, P., Curran, S., Gould, A., Richards, S., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001048 · Cited by 175

Inverse Agonist Activity of Atypical Antipsychotic Drugs at Human 5-Hydroxytryptamine2C Receptors

Herrick‐Davis, K., Grinde, E., & Teitler, M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38891-3 · Cited by 173

Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.

Kursar, J. D., Nelson, D. L., Wainscott, D. B., & Baez, M. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09676-2 · Cited by 171

The rat 5-hydroxytryptamine1B receptor is the species homologue of the human 5-hydroxytryptamine1D beta receptor.

Adham, N., Romanienko, P. J., Hartig, P. R., Weinshank, R. L., & Branchek, T. A. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08798-x · Cited by 171

Substance Abuse Disorder and Major Depression are Associated with the Human 5-HT1B Receptor Gene (HTR1B) G861C Polymorphism

Huang, Y., Oquendo, M. A., Harkavy‐Friedman, J., GREENHILL, L. L., Brodsky, B. S., Malone, K. M., Khait, V. D., & Mann, J. J. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300000 · Cited by 169

SB-216641 and BRL-15572 – compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors

Price, G. W., Burton, M. J., Collin, L. J., Duckworth, M. D., Gaster, L. M., Göthert, M., Jones, B. J., Roberts, C., Watson, J. M., & Middlemiss, D. N. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005056 · Cited by 168

Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes

Saltzman, A. G., Morse, B., Whitman, M. M., Ivanshchenko, Y., Jaye, M., & Felder, S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)92105-s · Cited by 168

5-HT1B and 5-HT1D receptors in the human trigeminal ganglion: co-localization with calcitonin gene-related peptide, substance P and nitric oxide synthase

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Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder

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