The role of 5-HT receptors in depression
Open accessAbstract
Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. In this review, we will discuss the evidence that links serotonin and serotonin receptors to the etiology of depression and the mechanisms underlying response to antidepressant treatment. We will then revisit the role of serotonin in three distinct hypotheses that have been proposed over the last several decades to explain the pathophysiology of depression: the monoamine, neurotrophic, and neurogenic hypotheses. Finally, we will discuss how recent studies into serotonin receptors have implicated specific neural circuitry in mediating the antidepressant response, with a focus being placed on the hippocampus.
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Serotonin receptor effects have been linked to antidepressant effects.
“the effects of serotonin receptors have been linked to antidepressant effects(Yohn et al., 2017)”
From Efficacy, acceptability and side-effects of oral versus long-acting- injectables antipsychotics: Systematic review and network meta-analysis (2024) · cites this paper as Yohn et al., 2017
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- Authors
- Yohn, C. N., Gergues, M. M., & Samuels, B. A.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Samuels, Benjamin Adam
- Venue
- Molecular Brain
- Published
- 2017-06-24
- Volume
- 10
- Issue
- 1
- Pages
- 28-28
- ISSN
- 1756-6606 (ISSN-L)
- PMC
- PMC5483313
- OpenAlex
- W2695471189
- Cited by
- 485
- References
- 190
- Citations by year
- 2026: 28 · 2025: 53 · 2024: 69 · 2023: 72 · 2022: 60 · 2021: 75 · 2020: 59 · 2019: 38 · 2018: 26 · 2017: 5
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Brain (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Brain and Behavior Research Foundation (NARSAD Young Investigator)
- National Institute of Mental Health (R01 MH112861)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- depression, serotonin receptors, serotonin, selective serotonin reuptake inhibitors, antidepressant response, monoamine hypothesis, neurotrophic hypothesis, hippocampus, neural circuits, depression pathophysiology
- MeSH terms
- Animals, Depression, Hippocampus, Humans, Models, Biological, Receptors, Serotonin, Serotonin, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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