CoChat
Sign Up
Cited by 44Birth, Development, and HealthMaternal Mental Health During Pregnancy and PostpartumPrenatal Substance Exposure Effects

Pre-and/or postnatal protein restriction developmentally programs affect and risk assessment behaviors in adult male rats

Reyes-Castro, L.A., Rodriguez, J.S., Rodríguez-González, G.L., Chavira, R., Bautista, C.J., McDonald, T.J., Nathanielsz, P.W., Zambrano, E.·2012·Behavioural Brain Research
DOI 10.1016/j.bbr.2011.06.008
Open this paper in CoChat — free account

Abstract

Developmental programming resulting from a suboptimal intrauterine environment can predispose offspring to a wide-range of lifelong health complications. Little is known about the effects maternal protein restriction during pregnancy and/or lactation has on offspring neurodevelopment. We hypothesized that maternal isocaloric low protein diet during pregnancy and/or lactation would negatively influence male offspring affect and risk assessment behaviors as measured by elevated plus maze and open field tests. Control mothers received 20% casein (C) and restricted mothers (R) 10% casein to provide four groups: CC, RR, CR, and RC (first letter pregnancy diet and second letter lactation diet) to evaluate effects of maternal diet on offspring risk assessment, anxiety and exploratory behaviors. Elevated plus maze results showed an effect of pre- and/or postnatal diet manipulation in open arm time (p<0.05) with increases seen in the RR (157±22.7s), CR (137±23.2s) and RC (146.8±10.8s) offspring relative to CC (52±8.6s) offspring. This behavior indicates decreased avoidance (less anxiety) and increased exploration by experimental groups. However, in the open field test the RR (17±4.2 entries) offspring entered the center zone less than the CC (35±6.6 entries) offspring thus exhibiting increased anxiety with no other groups showing effects. Elevated levels of corticosterone were measured before, during and after immobilization in the RR compared to CC offspring. These findings show protein restriction during critical periods of development negatively program offspring behavior. The underlying anatomical structures affected remain to be elucidated.

Integrity signals

Registry

Crossref · 10.1016/j.bbr.2011.06.008

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Maternal physiology, particularly stress and nutrition, can greatly impact the neural and behavioral development of offspring.

    “This is in keeping with a large body of research showing that maternal physiology, particularly stress (85–87) and nutrition (88–90), can greatly impact the neural and behavioral development of offspring.”

    From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [88]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Reyes-Castro, L. A., Rodriguez, J. S., Rodríguez-González, G. L., Chavira, R., Bautista, C. J., McDonald, T. J., Nathanielsz, P. W., & Zambrano, E.
Affiliations
  • The University of Texas at San Antonio Health Science Center (US)
  • Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
Corresponding author
Zambrano, E.
ORCID
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2012-02
Volume
227
Issue
2
Pages
324-329
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2011.06.008
OpenAlex
W2091993391
Cited by
44
References
64
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 4
FWCI
3.25
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
developmental programming, maternal protein restriction, low-protein diet, pregnancy, lactation, offspring neurodevelopment, anxiety-like behavior, exploratory behavior, risk assessment behavior, corticosterone, elevated plus maze, open field test, casein diet, intrauterine environment
MeSH terms
Animals, Animals, Newborn, Anxiety, Behavior, Animal, Exploratory Behavior, Female, Male, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, Diet, Protein-Restricted, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review