Cited by 64Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesDiet, Metabolism, and Disease

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

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Rebolledo-Solleiro, Daniela, Roldán-Roldán, Gabriel, Díaz, Daniel, Velasco, Myrian, Larqué, Carlos, Rico-Rosillo, Guadalupe, Vega-Robledo, Gloria Bertha, Zambrano, Elena +2 more·2017·PLoS ONE

Abstract

Metabolic syndrome (MS) is a cluster of signs that increases the risk to develop diabetes mellitus type 2 and cardiovascular disease. In the last years, a growing interest to study the relationship between MS and psychiatric disorders, such as depression and anxiety, has emerged obtaining conflicting results. Diet-induced MS rat models have only examined the effects of high-fat or mixed cafeteria diets to a limited extent. We explored whether an anxiety-like behavior was associated with MS in non-stressed rats chronically submitted to a high-sucrose diet (20% sucrose in drinking water) using three different anxiety paradigms: the shock-probe/burying test (SPBT), the elevated plus-maze (EPM) and the open-field test (OFT). Behaviorally, the high-sucrose diet group showed an increase in burying behavior in the SPBT. Also, these animals displayed both avoidance to explore the central part of the arena and a significant increase in freezing behavior in the OFT and lack of effects in the EPM. Also, high-sucrose diet group showed signs of an MS-like condition: significant increases in body weight and body mass index, abdominal obesity, hypertension, hyperglycemia, hyperinsulinemia, and dyslipidemia. Plasma leptin and resistin levels were also increased. No changes in plasma corticosterone levels were found. These results indicate that rats under a 24-weeks high-sucrose diet develop an MS associated with an anxiety-like behavior. Although the mechanisms underlying this behavioral outcome remain to be investigated, the role of leptin is emphasized.

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  • Prolonged intake of high sucrose or fructose diets can induce anxiety- and depressive-like behaviors and motivational deficits in rodents.

    “While sugar consumption can alleviate stress and pain and improve negative mood and emotional states in the short-term [52], prolonged intake of high sucrose or fructose diets can induce anxiety-and depressive-like behaviors and motivational deficits [53][54][55], effects that are more pronounced during the adolescent period [55][56][57].”

    From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [54]

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Authors
Rebolledo-Solleiro, D., Roldán-Roldán, G., Díaz, D., Velasco, M., Larqué, C., Rico-Rosillo, G., Vega-Robledo, G. B., Zambrano, E., Hiriart, M., & Pérez de la Mora, M.
Affiliations
  • Universidad Nacional Autónoma de México (MX)
  • Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (MX)
  • Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
Corresponding author
Rebolledo-Solleiro, Daniela
Venue
PLoS ONE
Published
2017-05-02
Volume
12
Issue
5
Pages
e0176554
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2611285972
Cited by
64
References
83
Citations by year
2026: 1 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 5 · 2017: 1
FWCI
4.18
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (IN204314, IN204014-3)
  • Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (MX) (CB-2013/220173)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
metabolic syndrome, anxiety-like behavior, high-sucrose diet, leptin, resistin, abdominal obesity, hyperinsulinemia, hyperglycemia, hypertension, dyslipidemia, freezing behavior, burying behavior, elevated plus maze, open field test, diet-induced obesity
MeSH terms
Animals, Anxiety, Blood Glucose, Blood Pressure, Disease Models, Animal, Insulin, Male, Rats, Wistar, Maze Learning, Metabolic Syndrome, Rats

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